| The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer. | The ASH1L-AS1-ASH1L axis controls NME1-mediated activation of the RAS signaling in gastric cancer.
Xie M, Zhang L, Han L, Huang L, Huang Y, Yang M, Zhang N. | 11/14/2023 |
| ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis. | ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
Yang X, Lu L, Wu C, Zhang F. | 03/19/2023 |
| High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model. | High PGD(2) receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.
Dash P, Ghatak S, Topi G, Satapathy SR, Ek F, Hellman K, Olsson R, Mehdawi LM, Sjölander A., Free PMC Article | 03/12/2022 |
| GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D2 in a Rab4-dependent mechanism. | GGA3 interacts with L-type prostaglandin D synthase and regulates the recycling and signaling of the DP1 receptor for prostaglandin D(2) in a Rab4-dependent mechanism.
Fréchette L, Binda C, Génier S, Degrandmaison J, Boisvert M, Parent JL. | 08/7/2021 |
| Promoter Genotyping and mRNA Expression - Based Analysis of the PTGDR Gene in Allergy. | Promoter Genotyping and mRNA Expression - Based Analysis of the PTGDR Gene in Allergy.
San Segundo-Val I, García-Sánchez A, Sanz C, Cornejo-García JA, Isidoro-García M, Dávila I. | 03/13/2021 |
| Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling. | Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.
He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y., Free PMC Article | 08/22/2020 |
| -type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor by interacting with the GTPase Rab4 | L-type prostaglandin D synthase regulates the trafficking of the PGD(2) DP1 receptor by interacting with the GTPase Rab4.
Binda C, Génier S, Degrandmaison J, Picard S, Fréchette L, Jean S, Marsault E, Parent JL., Free PMC Article | 06/13/2020 |
| We conclude that DP1 receptors promote the survival of eosinophils via serum response element induction and induction of pro-inflammatory genes | DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator.
Peinhaupt M, Roula D, Theiler A, Sedej M, Schicho R, Marsche G, Sturm EM, Sabroe I, Rothenberg ME, Heinemann A., Free PMC Article | 05/11/2019 |
| PGD2 signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus | Virus-induced inflammasome activation is suppressed by prostaglandin D(2)/DP1 signaling.
Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S., Free PMC Article | 06/9/2018 |
| Polymorphisms of prostaglandin D receptor (PTGDR) gene influence basal promoter activity and gene expression, as well as the cytokine secretory pattern. | PTGDR gene expression and response to dexamethasone treatment in an in vitro model.
Marcos-Vadillo E, García-Sánchez A, Sanz C, Davila I, Isidoro-García M., Free PMC Article | 11/18/2017 |
| An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma. These SNPs may be important determinants of differential response to latanoprost. | PTGFR and SLCO2A1 Gene Polymorphisms Determine Intraocular Pressure Response to Latanoprost in Han Chinese Patients with Glaucoma.
Zhang P, Jiang B, Xie L, Huang W. | 10/21/2017 |
| EP2 receptors seem to be able to distinguish endogenous ligands PGD2, PGE2 or prostaglandin F2alpha better than DP receptors. | Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands.
Suganami A, Fujino H, Okura I, Yanagisawa N, Sugiyama H, Regan JW, Tamura Y, Murayama T. | 07/15/2017 |
| PGD2 markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation. | Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.
Jandl K, Stacher E, Bálint Z, Sturm EM, Maric J, Peinhaupt M, Luschnig P, Aringer I, Fauland A, Konya V, Dahlen SE, Wheelock CE, Kratky D, Olschewski A, Marsche G, Schuligoi R, Heinemann A., Free PMC Article | 08/13/2016 |
| Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea | Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea.
Krishna R, Guo Y, Schulz V, Cord-Cruz E, Smith S, Hair S, Nahm WK, Draelos ZD. | 10/17/2015 |
| EP2 receptors exhibit more constraints to mutations than DP receptors. | Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors.
Tanimoto J, Fujino H, Takahashi H, Murayama T. | 05/2/2015 |
| Low DP1 prostanoid receptor is associated with gastric cancer progression. | The role of type D prostanoid receptors and PPARγ in gastric cancer progression.
Fukuoka T, Yashiro M, Morisaki T, Kinoshita H, Hasegawa T, Kasashima H, Masuda G, Sakurai K, Toyokawa T, Tanaka H, Kubo N, Muguruma K, Ohira M, Hirakawa K. | 08/23/2014 |
| Lipocalin-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor DP1 in an agonist-independent manner. | A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate.
Binda C, Génier S, Cartier A, Larrivée JF, Stankova J, Young JC, Parent JL., Free PMC Article | 04/12/2014 |
| the PTGDR -549 C/T polymorphism confers susceptibility to asthma in Europeans and adults. However, no association was found between the PTGDR 441 C/T and -197 C/T polymorphisms or the CCC and TCT haplotypes and asthma susceptibility. | PTGDR polymorphisms and susceptibility to asthma: a meta-analysis.
Lee YH, Choi SJ, Ji JD, Song GG. | 03/8/2014 |
| Genetic variant may play a role in NSAID induced acute urticaria. | Genetic variants of the arachidonic acid pathway in non-steroidal anti-inflammatory drug-induced acute urticaria.
Cornejo-García JA, Jagemann LR, Blanca-López N, Doña I, Flores C, Guéant-Rodríguez RM, Torres MJ, Fernández J, Laguna JJ, Rosado A, Agúndez JA, García-Martín E, Canto G, Guéant JL, Blanca M. | 06/1/2013 |
| PGD(2)-DP signaling reduces vascular permeability via endothelial cAMP/PKA/Tiam1/Rac1 pathway. | Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway.
Kobayashi K, Tsubosaka Y, Hori M, Narumiya S, Ozaki H, Murata T. | 04/13/2013 |
| The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the North Indian population. | No association of PTGDR -441C/T polymorphism with asthma in a North Indian population.
Birbian N, Singh J, Jindal SK, Joshi A, Batra N., Free PMC Article | 06/2/2012 |
| DP receptors amplify the biological response to CRTH2 activation and the CRTH2/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases | D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells.
Sedej M, Schröder R, Bell K, Platzer W, Vukoja A, Kostenis E, Heinemann A, Waldhoer M. | 04/14/2012 |
| Genetic combinations described have functional implications in the PTGDR promoter activity by changing the transcription factors affinity that will help characterize different risk groups. | PTGDR gene in asthma: a functional, genetic, and epigenetic study.
Isidoro-García M, Sanz C, García-Solaesa V, Pascual M, Pescador DB, Lorente F, Dávila I. | 02/25/2012 |
| PGD(2) can induce MUC5B overproduction via ERK MAPK/RSK1/CREB signaling and that DP1 receptor may have suppressive effects in controlling MUC5B overproduction in the airway. | The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling.
Choi YH, Lee SN, Aoyagi H, Yamasaki Y, Yoo JY, Park B, Shin DM, Yoon HG, Yoon JH., Free PMC Article | 11/26/2011 |
| Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma. | Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
Kang MJ, Kwon JW, Kim BJ, Yu J, Choi WA, Shin YJ, Hong SJ. | 08/27/2011 |