| Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils. | Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils.
Lavoie JC, Simard M, Kalkan H, Rakotoarivelo V, Huot S, Di Marzo V, Côté A, Pouliot M, Flamand N., | 09/19/2024 |
| Constitutive internalisation of EP2 differentially regulates G protein signalling. | Constitutive internalisation of EP2 differentially regulates G protein signalling.
Walker AR, Parkin HA, Hye Kim S, Terzidou V, Woodward DF, Bennett PR, Hanyaloglu AC., Free PMC Article | 08/5/2024 |
| Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors on osteoblast healing and organization of collagen. | Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors on osteoblast healing and organization of collagen.
Salama MA, Anwar Ismail A, Islam MS, K G AR, Al Kawas S, Samsudin AR, A C SA., Free PMC Article | 07/16/2024 |
| N6-methyladenosine Methyltransferase METTL3 Enhances PTGER2 Expression to Increase Ovarian Cancer Stemness and Chemoresistance. | N6-methyladenosine Methyltransferase METTL3 Enhances PTGER2 Expression to Increase Ovarian Cancer Stemness and Chemoresistance.
Lin YB, Xu BH. | 10/10/2023 |
| Complementary roles of EP2 and EP4 receptors in malignant glioma. | Complementary roles of EP2 and EP4 receptors in malignant glioma.
Qiu J, Li Q, Li J, Zhou F, Sang P, Xia Z, Wang W, Wang L, Yu Y, Jiang J., Free PMC Article | 09/15/2023 |
| Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP2 receptor upregulation in mouse and human kidney. | Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP(2) receptor upregulation in mouse and human kidney.
Tofteng SS, Nilsson L, Mogensen AK, Nørregaard R, Nüsing R, Diatchikhine M, Lund L, Bistrup C, Jensen BL, Madsen K., Free PMC Article | 07/30/2022 |
| Identification of ACOT13 and PTGER2 as novel candidate genes of autosomal dominant polycystic kidney disease through whole exome sequencing. | Identification of ACOT13 and PTGER2 as novel candidate genes of autosomal dominant polycystic kidney disease through whole exome sequencing.
Du N, Dong D, Sun L, Che L, Li X, Liu Y, Wang B., Free PMC Article | 03/19/2022 |
| Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values. | Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values.
El-Ansary A, Alhakbany M, Aldbass A, Qasem H, Al-Mazidi S, Bhat RS, Al-Ayadhi L., Free PMC Article | 02/26/2022 |
| Prostaglandin E2 EP receptors in cardiovascular disease: An update. | Prostaglandin E2 EP receptors in cardiovascular disease: An update.
Bryson TD, Harding P. | 01/22/2022 |
| The EP2 agonist, omidenepag, alters the physical stiffness of 3D spheroids prepared from human corneal stroma fibroblasts differently depending on the osmotic pressure. | The EP2 agonist, omidenepag, alters the physical stiffness of 3D spheroids prepared from human corneal stroma fibroblasts differently depending on the osmotic pressure.
Ida Y, Umetsu A, Furuhashi M, Watanabe M, Hikage F, Ohguro H. | 01/15/2022 |
| Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort. | Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort.
Mani S, Norel X, Varret M, Bchir S, Ben Anes A, Garrouch A, Tabka Z, Longrois D, Chahed K. | 12/25/2021 |
| Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-beta signalling. | Prostaglandin E(2) directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling.
Goepp M, Crittenden S, Zhou Y, Rossi AG, Narumiya S, Yao C., Free PMC Article | 12/18/2021 |
| The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD2 or PGE2. | The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD(2) or PGE(2).
Okura I, Hasuoka N, Senoo K, Suganami A, Fukushima K, Regan JW, Mashimo M, Murayama T, Tamura Y, Fujino H. | 12/11/2021 |
| Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines. | Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines.
Peng L, Ye Y, Mullikin H, Lin L, Kuhn C, Rahmeh M, Mahner S, Jeschke U, von Schönfeldt V. | 09/25/2021 |
| The role of EP-2 receptor expression in cervical intraepithelial neoplasia. | The role of EP-2 receptor expression in cervical intraepithelial neoplasia.
Schmoeckel E, Fraungruber P, Kuhn C, Jeschke U, Mahner S, Kolben TM, Kolben T, Vilsmaier T, Hester A, Heidegger HH., Free PMC Article | 07/17/2021 |
| Prostaglandin EP2 receptor downstream of Notch signaling inhibits differentiation of human skeletal muscle progenitors in differentiation conditions. | Prostaglandin EP2 receptor downstream of Notch signaling inhibits differentiation of human skeletal muscle progenitors in differentiation conditions.
Sakai-Takemura F, Nogami K, Elhussieny A, Kawabata K, Maruyama Y, Hashimoto N, Takeda S, Miyagoe-Suzuki Y., Free PMC Article | 06/19/2021 |
| Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor. | Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor.
Iwamoto K, Takahashi H, Okuzaki D, Osawa H, Ogino T, Miyoshi N, Uemura M, Matsuda C, Yamamoto H, Mizushima T, Mori M, Doki Y, Eguchi H., Free PMC Article | 03/20/2021 |
| Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E2 Activation in Human Podocytes. | Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E(2) Activation in Human Podocytes.
Mangelsen E, Rothe M, Schulz A, Kourpa A, Panáková D, Kreutz R, Bolbrinker J., Free PMC Article | 02/27/2021 |
| The prostaglandin receptor EP2 determines prognosis in EP3-negative and galectin-3-high cervical cancer cases. | The prostaglandin receptor EP2 determines prognosis in EP3-negative and galectin-3-high cervical cancer cases.
Dietlmeier S, Ye Y, Kuhn C, Vattai A, Vilsmaier T, Schröder L, Kost BP, Gallwas J, Jeschke U, Mahner S, Heidegger HH., Free PMC Article | 11/21/2020 |
| a role for EP2/EP4 signaling in regulating IGF-1-induced cell proliferation, in which EP2/EP4 signaling represses IGF-1-induced GGCT expression, is reported. | Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.
Takahashi T, Ichikawa H, Morimoto Y, Tsuneyama K, Hijikata T. | 07/4/2020 |
| EP2 and EP4 receptors play different roles in the regulation of COX-2 expression in human amnion fibroblasts. | Activation of prostaglandin EP4 receptor attenuates the induction of cyclooxygenase-2 expression by EP2 receptor activation in human amnion fibroblasts: implications for parturition.
Lu JW, Wang WS, Zhou Q, Gan XW, Myatt L, Sun K. | 05/23/2020 |
| These results suggest that PGE2 regulates human brain endothelial cell migration via cooperation of EP2, EP3, and EP4 receptors. | PGE(2) -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors.
Khan GA, Bhagat S, Alam MI. | 05/9/2020 |
| Altered Prostaglandin E2-EP2 augmented the excessive inflammation of innate and adaptive immune cells in response to lipopolysaccharides or E. coli in chronic hepatitis B-acute-on-chronic liver failure. | Altered PGE2-EP2 is associated with an excessive immune response in HBV-related acute-on-chronic liver failure.
Wang Y, Chen C, Qi J, Wu F, Guan J, Chen Z, Zhu H., Free PMC Article | 04/25/2020 |
| a signaling circuit involving RIPK3 and PGE2 receptors enhances accumulation and immunosuppressive activity of myeloid-derived suppressor cells | A RIPK3-PGE(2) Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis.
Yan G, Zhao H, Zhang Q, Zhou Y, Wu L, Lei J, Wang X, Zhang J, Zhang X, Zheng L, Du G, Xiao W, Tang B, Miao H, Li Y. | 10/12/2019 |
| COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases | Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases.
Chang LL, Hsu WH, Kao MC, Chou CC, Lin CC, Liu CJ, Weng BC, Kuo FC, Kuo CH, Lin MH, Wang CJ, Lin CH, Wu DC, Huang SK., Free PMC Article | 09/21/2019 |