| CBX8 promotes lung adenocarcinoma growth and metastasis through transcriptional repression of CDKN2C and SCEL. | CBX8 promotes lung adenocarcinoma growth and metastasis through transcriptional repression of CDKN2C and SCEL.
Chen H, Su Y, Yang L, Xi L, Li X, Lan B, Liu M, Xuan C. | 12/6/2023 |
| CBX8 Promotes Cell Proliferation and Metastasis and Leads to Radiotherapy Tolerance of Glioma Cells. | CBX8 Promotes Cell Proliferation and Metastasis and Leads to Radiotherapy Tolerance of Glioma Cells.
Liu Q, Li X, Gao W. | 02/11/2023 |
| CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2. | CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2.
Wu Y, Duan Y, Li X, Zhao R, Lan B, Zhang X, Wang X, Chen H, Feng S, Liu Z, Cheng Y, Xi L, Wang Y, Xue F, Xuan C. | 11/12/2022 |
| High Expression of a Cancer Stemness-Related Gene, Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is Associated with Poor Prognosis of Colorectal Cancer Patients. | High Expression of a Cancer Stemness-Related Gene, Chromobox 8 (CBX8), in Normal Tissue Adjacent to the Tumor (NAT) Is Associated with Poor Prognosis of Colorectal Cancer Patients.
Ng L, Li HS, Man AT, Chow AK, Foo DC, Lo OS, Pang RW, Law WL., Free PMC Article | 06/18/2022 |
| hsamiR429 targets CBX8 to promote cell apoptosis in diffuse large Bcell lymphoma. | hsa‑miR‑429 targets CBX8 to promote cell apoptosis in diffuse large B‑cell lymphoma.
Liang Y, Yu ZJ, Liu M, Liu HM, Zhang JZ, Xiong T, Tang YY, Huang ZP., Free PMC Article | 02/5/2022 |
| CBX8 interacts with chromatin PTEN and is involved in regulating mitotic progression. | CBX8 interacts with chromatin PTEN and is involved in regulating mitotic progression.
Choi BH, Colon TM, Lee E, Kou Z, Dai W., Free PMC Article | 11/13/2021 |
| KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway. | KPNA2 interaction with CBX8 contributes to the development and progression of bladder cancer by mediating the PRDM1/c-FOS pathway.
Zeng F, Luo L, Li D, Guo J, Guo M., Free PMC Article | 08/28/2021 |
| CBX8 acts as an independent RNA-binding protein to regulate the maturation of miR-378a-3p in colon cancer cells. | CBX8 acts as an independent RNA-binding protein to regulate the maturation of miR-378a-3p in colon cancer cells.
Song X, Ning W, Niu J, Zhang G, Liu H, Zhou L. | 08/7/2021 |
| Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. | Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ., Free PMC Article | 01/16/2021 |
| Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells. | Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells.
Xiao L, Zhou Z, Li W, Peng J, Sun Q, Zhu H, Song Y, Hou JL, Sun J, Cao HC, Zhongyi D, Wu D, Liu L., Free PMC Article | 09/5/2020 |
| Results establish CBX8 as a critical driver of HCC stem cell-like and metastatic behaviors and characterize its role in modulating BMP4 expression. | CBX8 exhibits oncogenic properties and serves as a prognostic factor in hepatocellular carcinoma.
Tang B, Tian Y, Liao Y, Li Z, Yu S, Su H, Zhong F, Yuan G, Wang Y, Yu H, Tomlinson S, Qiu X, He S., Free PMC Article | 04/4/2020 |
| function of the CBX8 chromodomain (CD) in vitro and in vivo; the CD is in fact a major driver of CBX8 chromatin association and this is driven by both histone and previously unrecognized DNA binding activity; characterization of the structural basis of histone and DNA binding and determine how they integrate on multiple levels | Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association.
Connelly KE, Weaver TM, Alpsoy A, Gu BX, Musselman CA, Dykhuizen EC., Free PMC Article | 10/12/2019 |
| Report shows that CBX8 is upregulated in esophageal squamous cell carcinoma (ESCC) tissues and cells and serves as an indicator of poor prognosis for ESCC patients. CBX8 knockdown inhibits cell proliferation, colony formation capability, DNA repair and promotes cell apoptosis. | CBX8 promotes tumorigenesis and confers radioresistance in esophageal squamous cell carcinoma cells through targeting APAF1.
Zhang Y, Chen H, Zhu H, Sun X. | 08/3/2019 |
| PIM1 can phosphorylate CBX8 to promote its degradation, thereby up-regulating p16, during PIM1-induced cell senescence. | PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast.
Zhan X, Yang J, Mao Z, Yu W. | 05/18/2019 |
| Circular RNA circ_0005230 was proved to be a sponge of miR-618, and expression of miR-618 could regulate CBX8 expression via targeting the 3'UTR of CBX8. | Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway.
Xu Y, Yao Y, Leng K, Ji D, Qu L, Liu Y, Cui Y. | 01/26/2019 |
| CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma. | CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma.
Zhang CZ, Chen SL, Wang CH, He YF, Yang X, Xie D, Yun JP. | 11/10/2018 |
| CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis. | CBX8 Suppresses Tumor Metastasis via Repressing Snail in Esophageal Squamous Cell Carcinoma.
Wang G, Tang J, Zhan W, Zhang R, Zhang M, Liao D, Wang X, Wu Y, Kang T., Free PMC Article | 07/7/2018 |
| The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients. | Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway.
Yuan GJ, Chen X, Lu J, Feng ZH, Chen SL, Chen RX, Wei WS, Zhou FJ, Xie D., Free PMC Article | 12/2/2017 |
| CBX8 plates roles in epigenetic regulation in DNA damage response. | A Novel Role of Chromodomain Protein CBX8 in DNA Damage Response.
Oza J, Ganguly B, Kulkarni A, Ginjala V, Yao M, Ganesan S., Free PMC Article | 09/30/2017 |
| CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis | EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
Béguelin W, Teater M, Gearhart MD, Calvo Fernández MT, Goldstein RL, Cárdenas MG, Hatzi K, Rosen M, Shen H, Corcoran CM, Hamline MY, Gascoyne RD, Levine RL, Abdel-Wahab O, Licht JD, Shaknovich R, Elemento O, Bardwell VJ, Melnick AM., Free PMC Article | 10/10/2017 |
| IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression | Insulin-Like Growth Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon Cancer Cell Apoptosis.
Yang S, Liu W, Li M, Wen J, Zhu M, Xu S. | 12/17/2016 |
| The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues. | Evaluating of suppressor of zeste 12 and chromobox homolog 8 genes expression showed two possible origins for gastric cancer development.
Ghalandary M, Behmanesh M, Sadeghizadeh M. | 11/5/2016 |
| These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment. | CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells.
Lee SH, Um SJ, Kim EJ. | 05/28/2016 |
| Low CBX8 expression was associated with distant metastasis in colorectal cancer. | Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer.
Tang J, Wang G, Zhang M, Li FY, Sang Y, Wang B, Hu K, Wu Y, Luo R, Liao D, Cao J, Wang X, Wang L, Zhang R, Zhang X, Deng WG, Xie D, Xu RH, Kang T., Free PMC Article | 09/5/2015 |
| CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy. | CBX8, a novel DNA repair protein, promotes tumorigenesis in human esophageal carcinoma.
Xiao W, Ou C, Qin J, Xing F, Sun Y, Li Z, Qiu J., Free PMC Article | 06/20/2015 |