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    Ppbp pro-platelet basic protein [ Mus musculus (house mouse) ]

    Gene ID: 57349, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    IFNalpha-induced BST2[+] tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.

    IFNα-induced BST2(+) tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling.
    Zheng C, Wang J, Zhou Y, Duan Y, Zheng R, Xie Y, Wei X, Wu J, Shen H, Ye M, Kong B, Liu Y, Xu P, Zhang Q, Liang T.

    04/30/2024
    CXCL7 aggravates the pathological manifestations of neuromyelitis optica spectrum disorder by enhancing the inflammatory infiltration of neutrophils, macrophages and microglia.

    CXCL7 aggravates the pathological manifestations of neuromyelitis optica spectrum disorder by enhancing the inflammatory infiltration of neutrophils, macrophages and microglia.
    Liu Z, Wang Y, Ding Y, Wang H, Zhang J, Wang H.

    12/3/2022
    PPBP as a marker of diabetic nephropathy podocyte injury via Bioinformatics Analysis.

    PPBP as a marker of diabetic nephropathy podocyte injury via Bioinformatics Analysis.
    Zhang F, Jiang N, Gao Y, Fan Z, Li Q, Ke G, Li B, Wu Q, Xu R, Liu S.

    11/27/2021
    FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells.

    FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells.
    Yan J, Zhao Q, Wang J, Tian X, Wang J, Xia X, Ott M, Rao G, Heimberger AB, Li S., Free PMC Article

    09/18/2021
    ELF4 binds to the promoter of genes of two C-X-C chemokines, Pf4 and pro-platelet basic protein (Ppbp), initiating the transcription of these two genes, thereby enhancing PF4-mediated killing of parasites from infected erythrocytes.

    ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp.
    Wang D, Zhang Z, Cui S, Zhao Y, Craft S, Fikrig E, You F., Free PMC Article

    12/14/2019
    Low CXCL7 expression is associated with posterior longitudinal ligament ossification.

    Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification.
    Tsuru M, Ono A, Umeyama H, Takeuchi M, Nagata K., Free PMC Article

    08/4/2018
    CXCR4(+) CD45(-) bone marrow cells are niche forming for osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 signaling pathways in bone marrow.

    CXCR4(+) CD45(-) Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow.
    Goto Y, Aoyama M, Sekiya T, Kakita H, Waguri-Nagaya Y, Miyazawa K, Asai K, Goto S.

    01/27/2018
    This is the first report that demonstrates Ppbp as a novel biomarker in the bronchial airway for lung cancer diagnosis.

    Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.
    Xiong D, Pan J, Zhang Q, Szabo E, Miller MS, Lubet RA, You M, Wang Y., Free PMC Article

    10/14/2017
    Platelet-derived CXCL7 and CXCL4 contribute to the pathogenesis of acute lung injury.

    Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury.
    Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M, Kowalska MA., Free PMC Article

    07/1/2017
    The findings suggest that CXCL7 attracts macrophages especially at the tumor site and may accelerate lung tumor development in the early stages.

    CXCL7-induced macrophage infiltration in lung tumor is independent of CXCR2 expression: CXCL7-induced macrophage chemotaxis in LLC tumors.
    Unver N, Esendagli G, Yilmaz G, Guc D.

    06/11/2016
    These results suggest that Cxcl4 and Cxcl7 play a role in the development of neurobehavioral alterations that are triggered by in utero TCDD exposure and later surface in adults.

    Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces expression of the chemokine genes Cxcl4 and Cxcl7 in the perinatal mouse brain.
    Mitsui T, Taniguchi N, Kawasaki N, Kagami Y, Arita J.

    08/13/2011
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