| TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma. | TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma.
Grewal R, Choung HYG, Roberts LL, Beane T, Chen L, Gilroy DX, Rappold PM, Le TH. | 01/21/2023 |
| Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort. | Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort.
Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Wang YT, Chen L, Wassertheil-Smoller S, Cai J, Isakson BE, Franceschini N, Le TH., Free PMC Article | 12/24/2022 |
| Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure. | Serum collectrin levels in patients with early- and late-onset preeclampsia.
Aslan Cetin B, Aydogan Mathyk B, Cift T, Tuten A, Bulut B, Yilmaz N, Erenel H, Ekmekci H, Gezer A. | 12/22/2018 |
| Lack of expression of the TMEM27 in conventional renal cell carcinoma defines a group of patients at high risk for cancer-related death. | Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.
Javorhazy A, Farkas N, Beothe T, Pusztai C, Szanto A, Kovacs G. | 02/18/2017 |
| Tmem27 is present in human serum and its levels are significantly lower in subjects with autoimmune diabetes as compared to healthy individuals. | Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes.
Pepaj M, Gjerlaugsen N, Julien K, Thorsby PM. | 05/16/2015 |
| Bace2 specifically targets Tmem27 and cleaves its extracellular domain, which is then shed from the plasma membrane of pancreatic beta cells. | Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
Esterházy D, Stützer I, Wang H, Rechsteiner MP, Beauchamp J, Döbeli H, Hilpert H, Matile H, Prummer M, Schmidt A, Lieske N, Boehm B, Marselli L, Bosco D, Kerr-Conte J, Aebersold R, Spinas GA, Moch H, Migliorini C, Stoffel M. | 06/26/2013 |
| Tmem27 dimerization is a dynamic process involving Bace2 | Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.
Esterházy D, Akpinar P, Stoffel M. | 09/29/2012 |
| Collectrin and ACE2 in renal and intestinal amino acid transport. | Collectrin and ACE2 in renal and intestinal amino acid transport.
Singer D, Camargo SM. | 02/18/2012 |
| Data support a role for TMEM27 in glucose-induced insulin secretion but not in cell proliferation. The finding that its cleavage is not specific to beta cells challenges the current support for its use as a potential beta cell mass biomarker. | The role of transmembrane protein 27 (TMEM27) in islet physiology and its potential use as a beta cell mass biomarker.
Altirriba J, Gasa R, Casas S, Ramírez-Bajo MJ, Ros S, Gutierrez-Dalmau A, Ruiz de Villa MC, Barbera A, Gomis R., Free PMC Article | 08/30/2010 |
| No TMEM27 gene mutations were discovered among 26 patients showing a phenotype resembling Dent's disease | Locus heterogeneity of Dent's disease: OCRL1 and TMEM27 genes in patients with no CLCN5 mutations.
Tosetto E, Addis M, Caridi G, Meloni C, Emma F, Vergine G, Stringini G, Papalia T, Barbano G, Ghiggeri GM, Ruggeri L, Miglietti N, D Angelo A, Melis MA, Anglani F. | 01/21/2010 |
| the first human study of the gene TMEM27 and an attempt to shine a light on genotype-phenotype correlation in Turner syndrome patients. | Collectrin gene screening in Turner syndrome patients with kidney malformation.
Pasquali L, d'Annunzio G, Gastaldi R, Di Battista E, Calcaterra V, Larizza D, Lorini R, D'Amato E. | 01/21/2010 |
| Collectrin has a role in amino acid transpor in the kidney [review] | Collectrin and the kidney.
Mount DB. | 01/21/2010 |