| Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1. | Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1.
Wang J, Li S, Li X, Liu J, Yang J, Li Y, Li W, Yang Y, Li J, Chen R, Li K, Huang D, Liu Y, Lv L, Li M, Xiao X, Luo XJ., Free PMC Article | 08/6/2022 |
| Investigated the role of NmrA like redox sensor 1 (HSCARG), a cellular redox sensor. Demonstrated how HSCARG interacts with proliferating cell nuclear antigen (PCNA) in the translesion synthesis pathway, and showed that HSCARG, which is highly expressed in breast carcinoma, promotes accumulation of double stranded breaks and mutations. | Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis.
Zang W, Yang C, Li T, Liao L, Zheng X., Free PMC Article | 04/18/2020 |
| These findings suggest that the increased susceptibility of the G6PD-knockdown cells to viral infection was due to impaired NF-kappaB signaling and antiviral response mediated by HSCARG. | Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling.
Wu YH, Chiu DT, Lin HR, Tang HY, Cheng ML, Ho HY., Free PMC Article | 10/1/2016 |
| After viral infection, HSCARG interacted with tumor necrosis receptor-associated factor 3 (TRAF3) and inhibited its ubiquitination by promoting the recruitment of OTUB1 to TRAF3. | HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.
Peng Y, Xu R, Zheng X., Free PMC Article | 12/20/2014 |
| Data indicate that HSCARG and USP7 function in concert in inhibiting polyubiquination of NEMO, thus inhibiting NF-kappaB activity. | HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination.
Li T, Guan J, Li S, Zhang X, Zheng X., Free PMC Article | 10/25/2014 |
| HSCARG is involved in DNA damage response through affecting the level of H2A ubiquitination and localization of RAP80 at lesion points. | HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation.
Hu B, Li S, Zhang X, Zheng X., Free PMC Article | 07/19/2014 |
| HSCARG regulated reactive-oxygen-species homeostasis through inhibition of NADPH oxidase activity via regulation of the expression of p47phox. | HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox.
Xiao W, Peng Y, Liu Y, Li Z, Li S, Zheng X., Free PMC Article | 09/21/2013 |
| CRM1 dependent nucleocytoplasmic translocation of HSCARG plays an important role in fine-tuning NF-kappaB signaling | A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity.
Zhang M, Hu B, Li T, Peng Y, Guan J, Lai S, Zheng X. | 10/6/2012 |
| HSCARG is involved in the NF-kappaB signaling pathway, and negatively regulates NF-kappaB activation. | HSCARG inhibits activation of NF-kappaB by interacting with IkappaB kinase-beta.
Gan Q, Li T, Hu B, Lian M, Zheng X. | 07/26/2010 |
| HSCARG plays critical roles in regulation of NF-kappaB in response to cellular redox changes by promoting ubiquitination and proteolysis of RelA or COMMD1 | HSCARG regulates NF-kappaB activation by promoting the ubiquitination of RelA or COMMD1.
Lian M, Zheng X., Free PMC Article | 01/21/2010 |
| In response to the changes in the NADPH/NADP(+) ratio within cells, HSCARG, as a redox sensor, associates and dissociates with NADPH to form a new dynamic equilibrium. | NADPH is an allosteric regulator of HSCARG.
Dai X, Li Y, Meng G, Yao S, Zhao Y, Yu Q, Zhang J, Luo M, Zheng X. | 01/21/2010 |
| HSCARG regulation of argininosuccinate synthetase activity is crucial for maintaining the intracellular balance between redox state and nitric oxide levels | An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability.
Zhao Y, Zhang J, Li H, Li Y, Ren J, Luo M, Zheng X. | 01/21/2010 |
| expression, crystallization and preliminary X-ray crystallographic studies of HSCARG at a resolution of 2.4 A; crystals belong to F23 space group, with unit cell parameters a=b=c=223.30A, alpha=beta=gamma=90 degrees | Protein expression, crystallization and preliminary X-ray crystallographic studies on HSCARG from Homo sapiens.
Dai X, Gu X, Luo M, Zheng X. | 01/21/2010 |
| One of the functions regulated by HSCARG may be argininosuccinate synthetase that is involved in NO synthesis | Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein.
Zheng X, Dai X, Zhao Y, Chen Q, Lu F, Yao D, Yu Q, Liu X, Zhang C, Gu X, Luo M., Free PMC Article | 01/21/2010 |