| Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners. | Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
Xu Y, Kusuyama J, Osana S, Matsuhashi S, Li L, Takada H, Inada H, Nagatomi R., Free PMC Article | 07/7/2023 |
| NDRG3 regulates imatinib resistance by promoting beta-catenin accumulation in the nucleus in chronic myelogenous leukemia. | NDRG3 regulates imatinib resistance by promoting β‑catenin accumulation in the nucleus in chronic myelogenous leukemia.
Wang X, Rong S, Sun Y, Yin B, Yang X, Lu X, Sun H, Yan Y, Sun G, Liang Y, Wang P, Xie S, Li Y., Free PMC Article | 06/28/2023 |
| The LINC01410/miR-122-5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells. | The LINC01410/miR-122-5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells.
Ma W, Zhao X, Xue N, Gao Y, Xu Q. | 01/29/2022 |
| High expression of NDRG3 correlates with poor prognosis in gastric cancer patients. | High expression of NDRG3 correlates with poor prognosis in gastric cancer patients.
Liu Y, Xia J, Zhou Y, Shao S. | 09/18/2021 |
| Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein. | Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein.
Kim KR, Kim KA, Park JS, Jang JY, Choi Y, Lee HH, Lee DC, Park KC, Yeom YI, Kim HJ, Han BW., Free PMC Article | 04/3/2021 |
| high NDRG3 expression facilitates HCC metastasis via regulating the turnover of beta-catenin, as well as provides a potential therapeutic target for future therapeutic interventions | High NDRG3 expression facilitates HCC metastasis by promoting nuclear translocation of β-catenin.
Shi J, Zheng H, Yuan L., Free PMC Article | 02/8/2020 |
| The results revealed that compared with non-tumor tissues, hepatocellular carcinoma tissues showed significantly higher NDRG3 expression. | NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma.
Jing JS, Li H, Wang SC, Ma JM, Yu LQ, Zhou H., Free PMC Article | 08/3/2019 |
| NDRG3 may have an anti-metastatic function in prostate cancer under a hypoxic microenvironment. | NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors.
Lee GY, Shin SH, Shin HW, Chun YS, Park JW., Free PMC Article | 03/23/2019 |
| The IHC data demonstrated that the NDRG3 expression was significantly correlated with pathological grade (p= 0.038), N (p= 0.020) and TNM stage (p= 0.002) in non-small cell lung cancer. | High expression of NDRG3 associates with unfavorable overall survival in non-small cell lung cancer.
Luo X, Hou N, Chen X, Xu Z, Xu J, Wang L, Yang S, Liu S, Xu L, Chen Y, Xiong L, Wang J, Fan W, Xu J. | 08/25/2018 |
| increased NDRG3 expression is associated with hepatocellular carcinoma and drug resistance. | MicroRNA31-NDRG3 regulation axes are essential for hepatocellular carcinoma survival and drug resistance.
Du Z, Niu S, Xu X, Xu Q. | 03/31/2018 |
| the expression of NDRG3 had significant impact on survival, with NDRG3 downregulated patients having the worst event-free survival rate among others. | Clinical significance of NDRG3 in patients with breast cancer.
Estiar MA, Zare AA, Esmaeili R, Farahmand L, Fazilaty H, Jafari D, Samadi T, Majidzadeh-A K. | 11/4/2017 |
| Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway. | Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A(2a) receptor through NDRG3-Raf-ERK pathway.
Cui C, Lin H, Shi Y, Pan R. | 08/26/2017 |
| above findings suggested that NDRG3 may be identified as a novel biomarker predicting the prognosis of laryngeal squamous cell carcinoma | High expression of NDRG3 associates with positive lymph node metastasis and unfavourable overall survival in laryngeal squamous cell carcinoma.
Ma J, Liu S, Zhang W, Zhang F, Wang S, Wu L, Yan R, Wu L, Wang C, Zha Z, Sun J. | 04/1/2017 |
| We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). | NDRG3-mediated lactate signaling in hypoxia.
Park KC, Lee DC, Yeom YI., Free PMC Article | 04/23/2016 |
| the aberrant expression of NDRG2 and NDRG3 may contribute to the malignant progression of prostate cancer | Prognostic impact of NDRG2 and NDRG3 in prostate cancer patients undergoing radical prostatectomy.
Ren GF, Tang L, Yang AQ, Jiang WW, Huang YM. | 12/6/2014 |
| summarizes the current research on NDRG3 and NDRG4,including the molecular structure, cellular and tissue distribution, biological function,and function in cancer. | NDRG3 and NDRG4, two novel tumor-related genes.
Yang X, An L, Li X. | 05/24/2014 |
| miR-122 plays an important role in HBV-related hepatocarcinogenesis by targeting NDRG3. | miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3.
Fan CG, Wang CM, Tian C, Wang Y, Li L, Sun WS, Li RF, Liu YG. | 03/3/2012 |
| NDRG3 is a tumor promoter, the overexpression of which may contribute to the malignant phenotype of tumors | NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth.
Wang W, Li Y, Li Y, Hong A, Wang J, Lin B, Li R. | 01/21/2010 |
| Cloning and expression of the gene; highly expressed in brain and testis | Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.
Qu X, Zhai Y, Wei H, Zhang C, Xing G, Yu Y, He F. | 01/21/2010 |