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    MIR498 microRNA 498 [ Homo sapiens (human) ]

    Gene ID: 574460, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Wilms' tumour gene 1 (WT1) enhances non-small cell lung cancer malignancy and is inhibited by microRNA-498-5p.

    Wilms' tumour gene 1 (WT1) enhances non-small cell lung cancer malignancy and is inhibited by microRNA-498-5p.
    Li X, An W, Pan H, Fan Y, Huang H, Wang Y, Shen W, Zu L, Meng F, Zhou X., Free PMC Article

    09/27/2023
    Hsa_circ_0079480 enhances cell proliferation, migration, and invasion in colorectal cancer through miR-498/ATP5E axis.

    Hsa_circ_0079480 enhances cell proliferation, migration, and invasion in colorectal cancer through miR-498/ATP5E axis.
    Lin RY, Huang ZM.

    03/16/2023
    LncRNA MALAT1 promotes decidualization of endometrial stromal cells via sponging miR-498-3p and targeting histone deacetylase 4.

    LncRNA MALAT1 promotes decidualization of endometrial stromal cells via sponging miR-498-3p and targeting histone deacetylase 4.
    Shi L, Zhu L, Gu Q, Kong C, Liu X, Zhu Z.

    07/30/2022
    miR-498/DNMT3b Axis Mediates Resistance to Radiotherapy in Esophageal Cancer Cells.

    miR-498/DNMT3b Axis Mediates Resistance to Radiotherapy in Esophageal Cancer Cells.
    Zhou W, Zhu H, Xu Y, Gu L, Wu W, Zhang Y, Huang X, Jiang Y.

    05/21/2022
    miR-498 Targets UBE2T to Inhibit the Proliferation of Malignant Melanoma Cells.

    miR-498 Targets UBE2T to Inhibit the Proliferation of Malignant Melanoma Cells.
    Cao W, Ni L, Li P, Wang QX, Li MM, Huang SH, Dang NN., Free PMC Article

    05/14/2022
    miR-498 inhibits autophagy and M2-like polarization of tumor-associated macrophages in esophageal cancer via MDM2/ATF3.

    miR-498 inhibits autophagy and M2-like polarization of tumor-associated macrophages in esophageal cancer via MDM2/ATF3.
    Li D, Yan M, Sun F, Song J, Hu X, Yu S, Tang L, Deng S.

    03/19/2022
    Knockdown of MIR93HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR498 via EP300.

    Knockdown of MIR9‑3HG inhibits proliferation and promotes apoptosis of cervical cancer cells by miR‑498 via EP300.
    Li F, Liang Y, Ying P., Free PMC Article

    01/8/2022
    Circular RNA hsa_circ_0032463 Acts as the Tumor Promoter in Osteosarcoma by Regulating the MicroRNA 498/LEF1 Axis.

    Circular RNA hsa_circ_0032463 Acts as the Tumor Promoter in Osteosarcoma by Regulating the MicroRNA 498/LEF1 Axis.
    Qin G, Wu X., Free PMC Article

    08/7/2021
    Up-regulation of miR-498 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting FOXO3.

    Up-regulation of miR-498 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting FOXO3.
    Li W, Jiang H.

    07/24/2021
    Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma.

    Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma.
    Xing Y, Sun X, Li F, Jiang X, Jiang A, Li X, Lv R, Shao L., Free PMC Article

    07/3/2021
    Down-regulation of long non-coding RNA DUXAP8 suppresses proliferation, metastasis and EMT by modulating miR-498 through TRIM44-mediated AKT/mTOR pathway in non-small-cell lung cancer.

    Down-regulation of long non-coding RNA DUXAP8 suppresses proliferation, metastasis and EMT by modulating miR-498 through TRIM44-mediated AKT/mTOR pathway in non-small-cell lung cancer.
    Ji X, Tao R, Sun LY, Xu XL, Ling W.

    03/20/2021
    Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis.

    Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis.
    Liu G, Zhou J, Piao Y, Zhao X, Zuo Y, Ji Z., Free PMC Article

    03/13/2021
    MicroRNA-498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl-2.

    MicroRNA-498 reduces the proliferation and invasion of colorectal cancer cells via targeting Bcl-2.
    Wang T, Ma L, Li W, Ding L, Gao H., Free PMC Article

    01/9/2021
    Our study demonstrated that TMS reduced gefitinib resistance in NSCLCs via suppression of the MAPK/Akt/Bcl-2 pathway by upregulation of miR-345/498.

    Trans-3,5,4´-trimethoxystilbene reduced gefitinib resistance in NSCLCs via suppressing MAPK/Akt/Bcl-2 pathway by upregulation of miR-345 and miR-498.
    Lu M, Liu B, Xiong H, Wu F, Hu C, Liu P., Free PMC Article

    07/11/2020
    down-regulation of miR-498 was negatively related to circFADS2 and mTOR expression in LPS-treated chondrocytes

    circFADS2 protects LPS-treated chondrocytes from apoptosis acting as an interceptor of miR-498/mTOR cross-talking.
    Li G, Tan W, Fang Y, Wu X, Zhou W, Zhang C, Zhang Y, Liu Y, Jiu G, Liu D., Free PMC Article

    06/20/2020
    aberrant expression of miR-498 changed the expression levels of phosphatase and tensin homolog and p-AKT in LNCaP and DU-145 PCa cells.

    MicroRNA-498 promotes proliferation, migration, and invasion of prostate cancer cells and decreases radiation sensitivity by targeting PTEN.
    Duan XM, Liu XN, Li YX, Cao YQ, Silayiding A, Zhang RK, Wang JP.

    04/11/2020
    TUG1 downregulation constrains cell proliferation and invasion through regulating CDC42 expression via miR-498 in esophageal squamous cell carcinoma cells

    Long Non-Coding RNA Taurine Upregulated Gene 1 (TUG1) Downregulation Constrains Cell Proliferation and Invasion through Regulating Cell Division Cycle 42 (CDC42) Expression Via MiR-498 in Esophageal Squamous Cell Carcinoma Cells.
    Wang Z, Liu J, Wang R, Wang Q, Liang R, Tang J., Free PMC Article

    03/21/2020
    the miR-498 was found to target the 3'-UTR of lncRNA CASC11 and FOXK1 mRNA.

    SP1 induced lncRNA CASC11 accelerates the glioma tumorigenesis through targeting FOXK1 via sponging miR-498.
    Jin J, Zhang S, Hu Y, Zhang Y, Guo C, Feng F.

    01/11/2020
    miR-498 may serve as a tumor suppressor in NSCLC through targeting HMGA2.

    Targeting the HMGA2 oncogene by miR-498 inhibits non-small cell lung cancer biological behaviors.
    Gao N, Wang FX, Wang G, Zhao QS.

    11/30/2019
    Low miR498 expression is associated with invasion of cervical cancer.

    Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling.
    Rong X, Gao W, Yang X, Guo J.

    11/9/2019
    MIRN498 promotes cell proliferation and inhibits cell apoptosis in retinoblastoma cell lines by directly targeting CCPG1.

    miR-498 promotes cell proliferation and inhibits cell apoptosis in retinoblastoma by directly targeting CCPG1.
    Yang L, Wei N, Wang L, Wang X, Liu QH.

    06/23/2019
    UFC1 has a promoting role in GC progression, at least in part, by acting as a miR-498 sponge and derepressing Lin28b expression, which would provide a novel biomarker for GC diagnosis and prognosis and offer a potential target for GC therapy.

    Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b.
    Zhang X, Liang W, Liu J, Zang X, Gu J, Pan L, Shi H, Fu M, Huang Z, Zhang Y, Qian H, Jiang P, Xu W., Free PMC Article

    05/11/2019
    Bioinformatics analysis showed that miR-498 contained the complementary binding region of hsa_circRNA_100833 (identified as circFADS2), which was confirmed by Dual-luciferase reporter assay. In addition, the expression of miR-498 was down-regulated and negatively associated with circFADS2 expression in non small cell lung cancer.

    circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498.
    Zhao F, Han Y, Liu Z, Zhao Z, Li Z, Jia K., Free PMC Article

    04/20/2019
    miR-498 directly targeted the 3'untranslated region of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) mRNA and reduced PTEN protein levels in Triple negative breast cancer cells.

    MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells.
    Chai C, Wu H, Wang B, Eisenstat DD, Leng RP., Free PMC Article

    03/23/2019
    Study demonstrated that miR498 suppresses the growth and metastasis of liver cancer cells, partly at least, by directly targeting ZEB2, suggesting that miR498 may serve as a potential biomarker for the diagnosis and therapy of liver cancer.

    miR‑498 inhibits the growth and metastasis of liver cancer by targeting ZEB2.
    Zhang X, Xu X, Ge G, Zang X, Shao M, Zou S, Zhang Y, Mao Z, Zhang J, Mao F, Qian H, Xu W., Free PMC Article

    03/9/2019
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