| Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis. | Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
Yeshaw WM, Adhikari A, Chiang CY, Dhekne HS, Wawro PS, Pfeffer SR., Free PMC Article | 11/1/2023 |
| Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes. | Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.
Dou D, Smith EM, Evans CS, Boecker CA, Holzbaur ELF., Free PMC Article | 06/7/2023 |
| PPM1H is an independent prognostic biomarker of non-small cell lung cancer. | PPM1H is an independent prognostic biomarker of non-small cell lung cancer.
Zhang WQ, Gao JN, Chen XL, Yang XF. | 10/16/2021 |
| PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins | PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.
Berndsen K, Lis P, Yeshaw WM, Wawro PS, Nirujogi RS, Wightman M, Macartney T, Dorward M, Knebel A, Tonelli F, Pfeffer SR, Alessi DR., Free PMC Article | 05/9/2020 |
| Lack of tumour PPM1H expression identifies a patient subgroup with a high relapse risk, and CRC cells with low expression of PPM1H activate cancer-association fibroblasts (CAFs) and inversely get promoted by CAFs. | Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts.
Xu X, Zhu L, Yang Y, Pan Y, Feng Z, Li Y, Chang W, Sui J, Cao F., Free PMC Article | 03/7/2020 |
| PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer | Effect of PPM1H on malignant phenotype of human pancreatic cancer cells.
Zhu H, Qin H, Li DM, Liu J, Zhao Q. | 03/11/2017 |
| PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. | Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.
Shen T, Sun C, Zhang Z, Xu N, Duan X, Feng XH, Lin X., Free PMC Article | 01/10/2015 |
| Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. | PPM1H is a p27 phosphatase implicated in trastuzumab resistance.
Lee-Hoeflich ST, Pham TQ, Dowbenko D, Munroe X, Lee J, Li L, Zhou W, Haverty PM, Pujara K, Stinson J, Chan SM, Eastham-Anderson J, Pandita A, Seshagiri S, Hoeflich KP, Turashvili G, Gelmon KA, Aparicio SA, Davis DP, Sliwkowski MX, Stern HM. | 11/24/2012 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCase-control genome-wide association study of attention-deficit/hyperactivity disorder.
Neale BM, Medland S, Ripke S, Anney RJ, Asherson P, Buitelaar J, Franke B, Gill M, Kent L, Holmans P, Middleton F, Thapar A, Lesch KP, Faraone SV, Daly M, Nguyen TT, Schäfer H, Steinhausen HC, Reif A, Renner TJ, Romanos M, Romanos J, Warnke A, Walitza S, Freitag C, Meyer J, Palmason H, Rothenberger A, Hawi Z, Sergeant J, Roeyers H, Mick E, Biederman J, IMAGE II Consortium Group. Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.
Kariuki SN, Franek BS, Kumar AA, Arrington J, Mikolaitis RA, Utset TO, Jolly M, Crow MK, Skol AD, Niewold TB. | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein. | Protein phosphatase 1H, overexpressed in colon adenocarcinoma, is associated with CSE1L.
Sugiura T, Noguchi Y, Sakurai K, Hattori C. | 01/21/2010 |