| FOXP4-mediated induction of PTK7 activates the Wnt/beta-catenin pathway and promotes ovarian cancer development. | FOXP4-mediated induction of PTK7 activates the Wnt/β-catenin pathway and promotes ovarian cancer development.
Ji J, Qian Q, Cheng W, Ye X, Jing A, Ma S, Ding Y, Ma X, Wang Y, Sun Q, Wang X, Chen Y, Zhu L, Yuan Q, Xu M, Qin J, Ma L, Yang J, Zhang M, Geng T, Wang S, Wang D, Song Y, Zhang B, Xu Y, Xu L, Liu S, Liu W, Liu B., Free PMC Article | 07/11/2024 |
| Elucidating the Functional Mechanism of PTK7 in Cancer Development through Spatial Assembly Analysis Using Super Resolution Imaging. | Elucidating the Functional Mechanism of PTK7 in Cancer Development through Spatial Assembly Analysis Using Super Resolution Imaging.
Qiu L, Xu H, Sui B, Jiang P, Wang J, Xu D, Liang F, Ma T, Wang H, Chen J. | 07/1/2024 |
| Knockdown of PTK7 Reduces the Oncogenic Potential of Breast Cancer Cells by Impeding Receptor Tyrosine Kinase Signaling. | Knockdown of PTK7 Reduces the Oncogenic Potential of Breast Cancer Cells by Impeding Receptor Tyrosine Kinase Signaling.
Shin WS, Oh SW, Park HN, Kim JH, Lee ST., Free PMC Article | 08/19/2023 |
| Proteomic and Phosphoproteomic Analyses Reveal the Oncogenic Role of PTK7-NDRG1 Axis in Non-small-cell Lung Cancer Cell Resistance to AZD9291. | Proteomic and Phosphoproteomic Analyses Reveal the Oncogenic Role of PTK7-NDRG1 Axis in Non-small-cell Lung Cancer Cell Resistance to AZD9291.
Wang Z, Lei P, Li Z, Han X, Yang F, Su T, Meng C, Hou Z, Liu H. | 10/29/2022 |
| Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves. | Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves.
Chan MMY, Sadeghi-Alavijeh O, Lopes FM, Hilger AC, Stanescu HC, Voinescu CD, Beaman GM, Newman WG, Zaniew M, Weber S, Ho YM, Connolly JO, Wood D, Maj C, Stuckey A, Kousathanas A, Genomics England Research Consortium, Kleta R, Woolf AS, Bockenhauer D, Levine AP, Gale DP., Free PMC Article | 10/8/2022 |
| High expression of protein tyrosine kinase 7 in oral squamous cell carcinoma: Clinicopathological correlation and prognosis relevance. | High expression of protein tyrosine kinase 7 in oral squamous cell carcinoma: Clinicopathological correlation and prognosis relevance.
Kimura Y, Yoshizawa K, Hotta-Osada A, Moroi A, Ishii H, Sakurai D, Saitoh M, Oishi N, Kondo T, Ueki K., Free PMC Article | 05/7/2022 |
| PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells. | PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells.
Shin WS, Park MK, Kim JH, Oh SW, Jang JY, Lee H, Lee ST., Free PMC Article | 03/26/2022 |
| Whole-Exome Sequencing Identifies a Novel Germline Variant in PTK7 Gene in Familial Colorectal Cancer. | Whole-Exome Sequencing Identifies a Novel Germline Variant in PTK7 Gene in Familial Colorectal Cancer.
Miao B, Skopelitou D, Srivastava A, Giangiobbe S, Dymerska D, Paramasivam N, Kumar A, Kuświk M, Kluźniak W, Paszkowska-Szczur K, Schlesner M, Lubinski J, Hemminki K, Försti A, Bandapalli OR., Free PMC Article | 03/12/2022 |
| The Mutational Landscape of PTK7 in Congenital Scoliosis and Adolescent Idiopathic Scoliosis. | The Mutational Landscape of PTK7 in Congenital Scoliosis and Adolescent Idiopathic Scoliosis.
Su Z, Yang Y, Wang S, Zhao S, Zhao H, Li X, Niu Y, Deciphering Disorders Involving Scoliosis And COmorbidities Disco Study Group, Qiu G, Wu Z, Wu N, Zhang TJ., Free PMC Article | 02/12/2022 |
| LncRNA-MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR-205-PTK7 pathway. | LncRNA-MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR-205-PTK7 pathway.
Song Y, Guo NH, Zheng JF. | 08/21/2021 |
| PTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomas. | PTK7 expression is associated with lymph node metastasis, ALK and EGFR mutations in lung adenocarcinomas.
Jiang W, He J, Lv B, Xi X, He G, He J. | 05/22/2021 |
| Identification of PTK7 as a promising therapeutic target for thyroid cancer. | Identification of PTK7 as a promising therapeutic target for thyroid cancer.
Duan F, Tang J, Kong FL, Zou HW, Ni BL, Yu JC. | 05/8/2021 |
| Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases. | Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA., Free PMC Article | 08/29/2020 |
| In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma. | In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma.
Yang M, Hlady RA, Zhou D, Ho TH, Robertson KD., Free PMC Article | 08/22/2020 |
| data demonstrate that PTK7 binds and activates FGFR1 independent of FGF and thus increases oncogenicity of PTK7- and FGFR1-positive cancers such as esophageal squamous cell carcinoma. | Catalytically inactive receptor tyrosine kinase PTK7 activates FGFR1 independent of FGF.
Shin WS, Lee HW, Lee ST., Free PMC Article | 07/4/2020 |
| ENST00000489707.5 is a preferred alternative splicing product of PTK7, with a significantly increased proportion in Adrenocortical Cancer compared with other cancers. Its expression shows potential prognostic value in terms of progression-free survival and disease-specific survival in Adrenocortical Cancer patients. | ENST00000489707.5 Is a Preferred Alternative Splicing Variant of PTK7 in Adrenocortical Cancer and Shows Potential Prognostic Value.
Bie J, Liu K, Song G, Hu X, Xiong R, Zhang X, Shi X, Wang Z., Free PMC Article | 03/21/2020 |
| These results demonstrate that PTK7 biphasically regulates tumorigenesis in esophageal squamous cell carcinoma. | Biphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma.
Shin WS, Gim J, Won S, Lee ST., Free PMC Article | 10/12/2019 |
| PTK7 protein expression was elevated in cervical cancer tissue and associated with poor prognosis. PTK7 knockdown inhibited cancer cell proliferation and migration. | The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer.
Sun JJ, Li HL, Guo SJ, Ma H, Liu SJ, Liu D, Xue FX., Free PMC Article | 07/20/2019 |
| Rare missense variants in PTK7 contribute to the genetic risk of spina bifida. | Variants identified in PTK7 associated with neural tube defects.
Lei Y, Kim SE, Chen Z, Cao X, Zhu H, Yang W, Shaw GM, Zheng Y, Zhang T, Wang HY, Finnell RH., Free PMC Article | 05/25/2019 |
| we report a novel strategy for obtaining ZnZr bimetallic MOFs via the MOF-on-MOF method and exploit them as an aptasensor platform for detecting the cancer marker protein tyrosine kinase-7 (PTK7) | Two-dimensional oriented growth of Zn-MOF-on-Zr-MOF architecture: A highly sensitive and selective platform for detecting cancer markers.
Zhou N, Su F, Guo C, He L, Jia Z, Wang M, Jia Q, Zhang Z, Lu S. | 03/23/2019 |
| miR2055p is involved in the proliferation, migration and invasion of colorectal cancer cells through inhibiting PTK7. | miR‑205‑5p/PTK7 axis is involved in the proliferation, migration and invasion of colorectal cancer cells.
Chen S, Wang Y, Su Y, Zhang L, Zhang M, Li X, Wang J, Zhang X., Free PMC Article | 09/15/2018 |
| Higher expression of PTK7 significantly indicates worse prognosis in human malignancies | Prognostic significance of PTK7 in human malignancies.
Chen G, Qi S, Yang X, Chen W. | 09/8/2018 |
| Inhibition of PTK7 by siRNA treatment significantly decreases the viability of atypical teratoid rhabdoid tumors (ATRT)patient-derived tumor cell lines.These studies provide the groundwork for future preclinical in vivo studies aiming to investigate the efficacy of PTK7 inhibition on ATRT tumor growth | Therapeutic Targeting of PTK7 is Cytotoxic in Atypical Teratoid Rhabdoid Tumors.
Messerli SM, Hoffman MM, Gnimpieba EZ, Bhardwaj RD., Free PMC Article | 04/21/2018 |
| PTK7 localization and protein stability is affected by canonical Wnt ligands. | PTK7 localization and protein stability is affected by canonical Wnt ligands.
Berger H, Breuer M, Peradziryi H, Podleschny M, Jacob R, Borchers A. | 03/17/2018 |
| These findings demonstrate that PTK7 upregulates MMP9 through activation of AP-1 and NF-kappaB and, thus increases invasive properties of ESCC cells. | Catalytically defective receptor protein tyrosine kinase PTK7 enhances invasive phenotype by inducing MMP-9 through activation of AP-1 and NF-κB in esophageal squamous cell carcinoma cells.
Shin WS, Hong Y, Lee HW, Lee ST., Free PMC Article | 03/10/2018 |