| TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer. | TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton in Breast Cancer.
Idrissou M, Boisnier T, Sanchez A, Khoufaf FZH, Penault-Llorca F, Bignon YJ, Bernard-Gallon D., Free PMC Article | 06/26/2021 |
| Taken together, the findings suggest that a protein-protein interaction between ATM and p400 ATPase occurs independently of DNA damage and contributes to efficient DNA damage response and repair. | Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response.
Smith RJ, Savoian MS, Weber LE, Park JH., Free PMC Article | 09/16/2017 |
| All together these results show that p400 acts as a brake to prevent alternative End Joining-dependent genetic instability and underline its potential value as a clinical marker. | Control of alternative end joining by the chromatin remodeler p400 ATPase.
Taty-Taty GC, Chailleux C, Quaranta M, So A, Guirouilh-Barbat J, Lopez BS, Bertrand P, Trouche D, Canitrot Y., Free PMC Article | 07/30/2016 |
| EP400 deposits H3.3 into chromatin alongside H2AZ and contributes to gene regulation after Pol II pre-initiation complex assembly. | EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation.
Pradhan SK, Su T, Yen L, Jacquet K, Huang C, Côté J, Kurdistani SK, Carey MF., Free PMC Article | 05/28/2016 |
| Data indicate that three genes, namely Chemokine (C-X-C motif) receptor 2 (CXCR2), C-C chemokine receptor type 2 (CCR2) and E1A-Binding Protein P400 (EP400), were able to identify HCC individually with accuracies of 82.4%, 78.4% and 65%, respectively. | A blood-based three-gene signature for the non-invasive detection of early human hepatocellular carcinoma.
Shi M, Chen MS, Sekar K, Tan CK, Ooi LL, Hui KM. | 05/10/2014 |
| Our data suggest that the highly proliferative, decreased-p400 subgroup of renal cell carcinomas represents tumors that are characterized by a loss of the tumor-suppressive mechanism of senescence. | Senescence-associated protein p400 is a prognostic marker in renal cell carcinoma.
Macher-Goeppinger S, Bermejo JL, Schirmacher P, Pahernik S, Hohenfellner M, Roth W. | 04/12/2014 |
| age-dependent p400 downregulation and loss of H2A.Z localisation may contribute to the onset of replicative senescence through a sustained high rate of p21 transcription | Decrease of p400 ATPase complex and loss of H2A.Z within the p21 promoter occur in senescent IMR-90 human fibroblasts.
Lee K, Lau ZZ, Meredith C, Park JH. | 05/25/2013 |
| The p400 ATPase is required for DNA repair by homologous recombination. | The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.
Courilleau C, Chailleux C, Jauneau A, Grimal F, Briois S, Boutet-Robinet E, Boudsocq F, Trouche D, Canitrot Y., Free PMC Article | 02/23/2013 |
| incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation | The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.
Couture JP, Nolet G, Beaulieu E, Blouin R, Gévry N. | 02/2/2013 |
| p400 is a novel DNA damage response protein and p400-mediated alterations in nucleosome and chromatin structure promote both chromatin ubiquitination and the accumulation of brca1 and 53BP1 at sites of DNA damage. | The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
Xu Y, Sun Y, Jiang X, Ayrapetov MK, Moskwa P, Yang S, Weinstock DM, Price BD., Free PMC Article | 11/13/2010 |
| Depletion of p400 indeed increases intracellular reactive oxygen species levels and causes the appearance of DNA damage | The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis.
Mattera L, Courilleau C, Legube G, Ueda T, Fukunaga R, Chevillard-Briet M, Canitrot Y, Escaffit F, Trouche D., Free PMC Article | 10/4/2010 |
| Results suggest that p400 represses basal p21 gene expression through dual mechanisms that include direct inhibition of TIP60 and ATP-dependent positioning of H2A.Z at the promoter. | The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression.
Park JH, Sun XJ, Roeder RG., Free PMC Article | 06/14/2010 |
| p400/Tip60 ratio is critical for colon cancer cells proliferation and response to therapeutic drugs through the control of stress-response pathways. | The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways.
Mattera L, Escaffit F, Pillaire MJ, Selves J, Tyteca S, Hoffmann JS, Gourraud PA, Chevillard-Briet M, Cazaux C, Trouche D. | 01/21/2010 |
| Myc recruits the Tip60/p400 complex to achieve a coordinated histone acetylation/exchange reaction at activated promoters. | Analysis of Myc-induced histone modifications on target chromatin.
Martinato F, Cesaroni M, Amati B, Guccione E., Free PMC Article | 01/21/2010 |
| These findings establish that Myc, via p400, is an essential downstream target of adenovirus E1A. | Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.
Tworkowski KA, Chakraborty AA, Samuelson AV, Seger YR, Narita M, Hannon GJ, Lowe SW, Tansey WP., Free PMC Article | 01/21/2010 |
| p400 is a component of the p53-p21(WAF1/CIP1/sid1) pathway, regulating the p21 transcription and cell senescence induction program. | The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway.
Chan HM, Narita M, Lowe SW, Livingston DM., Free PMC Article | 01/21/2010 |
| p400 is a regulator of the ARF-p53 pathway and a component of the cellular machinery that couples proliferation to cell death | p400 is required for E1A to promote apoptosis.
Samuelson AV, Narita M, Chan HM, Jin J, de Stanchina E, McCurrach ME, Narita M, Fuchs M, Livingston DM, Lowe SW. | 01/21/2010 |
| Tip60 and p400 play distinct roles in DNA damage-induced apoptosis and underline the importance of the Tip60 complex and its regulation in the proper control of cell fate. | Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.
Tyteca S, Vandromme M, Legube G, Chevillard-Briet M, Trouche D., Free PMC Article | 01/21/2010 |