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    CAMSAP3 calmodulin regulated spectrin associated protein family member 3 [ Homo sapiens (human) ]

    Gene ID: 57662, updated on 6-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CAMSAP3, a microtubule orientation regulator, plays a vital role in manifesting differentiation-dependent characteristics in keratinocytes.

    CAMSAP3, a microtubule orientation regulator, plays a vital role in manifesting differentiation-dependent characteristics in keratinocytes.
    Kobori M, Abe J, Saito R, Hirai Y.

    02/4/2024
    CAMSAP3 negatively regulates lung cancer cell invasion and angiogenesis through nucleolin/HIF-1alpha mRNA complex stabilization.

    CAMSAP3 negatively regulates lung cancer cell invasion and angiogenesis through nucleolin/HIF-1α mRNA complex stabilization.
    Seephan S, Sasaki SI, Wattanathamsan O, Singharajkomron N, He K, Ucche S, Kungsukool S, Petchjorm S, Chantaravisoot N, Wongkongkathep P, Hayakawa Y, Pongrakhananon V.

    04/26/2023
    Rab14/MACF2 complex regulates endosomal targeting during cytokinesis.

    Rab14/MACF2 complex regulates endosomal targeting during cytokinesis.
    Gibieža P, Peterman E, Hoffman HK, Van Engeleburg S, Skeberdis VA, Prekeris R., Free PMC Article

    09/18/2021
    Findings suggest that CAMSAP3 functions to protect lung carcinoma cells against EMT by suppressing Akt activity via microtubule regulation and that CAMSAP3 loss promotes EMT in these cells.

    Loss of CAMSAP3 promotes EMT via the modification of microtubule-Akt machinery.
    Pongrakhananon V, Wattanathamsan O, Takeichi M, Chetprayoon P, Chanvorachote P.

    01/11/2020
    data suggest that CDH23-C is a CAMSAP3/Marshalin-binding protein that can modify MT networks indirectly through its interaction with CAMSAP3/Marshalin.

    Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3's Function.
    Takahashi S, Mui VJ, Rosenberg SK, Homma K, Cheatham MA, Zheng J., Free PMC Article

    05/12/2018
    CAMSAP3-dependent Golgi vesicle clustering and graded microtubule dynamics

    CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells.
    Wang J, Xu H, Jiang Y, Takahashi M, Takeichi M, Meng W.

    10/28/2017
    in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends.

    Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7.
    Noordstra I, Liu Q, Nijenhuis W, Hua S, Jiang K, Baars M, Remmelzwaal S, Martin M, Kapitein LC, Akhmanova A.

    08/5/2017
    ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments.

    The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics.
    Ning W, Yu Y, Xu H, Liu X, Wang D, Wang J, Wang Y, Meng W.

    06/24/2017
    These findings demonstrate that apically localized CAMSAP3 determines the proper orientation of microtubules, and in turn that of organelles, in mature mammalian epithelial cells.

    CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells.
    Toya M, Kobayashi S, Kawasaki M, Shioi G, Kaneko M, Ishiuchi T, Misaki K, Meng W, Takeichi M., Free PMC Article

    06/28/2016
    The CKK domain binds microtubules and represents a domain that evolved with the metazoa.

    The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins.
    Baines AJ, Bignone PA, King MD, Maggs AM, Bennett PM, Pinder JC, Phillips GW.

    09/19/2011
    KIAA1543 is a non-centrosomal minus end binding protein. It is termed Nezha(a character in Chinese mythic novel (Journey to the West)).

    Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts.
    Meng W, Mushika Y, Ichii T, Takeichi M.

    04/14/2009
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