| A potential histone-chaperone activity for the MIER1 histone deacetylase complex. | A potential histone-chaperone activity for the MIER1 histone deacetylase complex.
Wang S, Fairall L, Pham TK, Ragan TJ, Vashi D, Collins MO, Dominguez C, Schwabe JWR., Free PMC Article | 07/24/2023 |
| Histone deacetylase assays confirmed that MIER2, but not MIER3 complexes, have associated deacetylase activity. | Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
Derwish R, Paterno GD, Gillespie LL., Free PMC Article | 08/19/2017 |
| Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases | Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
Lakisic G, Lebreton A, Pourpre R, Wendling O, Libertini E, Radford EJ, Le Guillou M, Champy MF, Wattenhofer-Donzé M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppée JY, Ferguson-Smith AC, Cossart P, Bierne H., Free PMC Article | 08/13/2016 |
| Insulin and IGF-1 alter the subcellular localization of MIER1alpha in breast carcinoma cells. | Insulin and IGF-1, but not 17β-estradiol, alter the subcellular localization of MIER1α in MCF7 breast carcinoma cells.
Li S, Paterno GD, Gillespie LL., Free PMC Article | 03/19/2016 |
| nuclear targeting of MIER1alpha requires an intact ELM2 domain and is dependent on interaction with HDAC1/2 | Nuclear localization of the transcriptional regulator MIER1α requires interaction with HDAC1/2 in breast cancer cells.
Li S, Paterno GD, Gillespie LL., Free PMC Article | 03/7/2015 |
| the first immunohistochemical study of the MIER1alpha protein expression pattern in human tissues, is reported. | Protein expression pattern of human MIER1 alpha, a novel estrogen receptor binding protein.
McCarthy PL, Paterno GD, Gillespie LL., Free PMC Article | 04/19/2014 |
| Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells | Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells.
Clements JA, Mercer FC, Paterno GD, Gillespie LL., Free PMC Article | 09/1/2012 |
| Loss of nuclear MI-ER1 alpha might contribute to the development of invasive breast carcinoma | Changes in subcellular localisation of MI-ER1 alpha, a novel oestrogen receptor-alpha interacting protein, is associated with breast cancer progression.
McCarthy PL, Mercer FC, Savicky MW, Carter BA, Paterno GD, Gillespie LL., Free PMC Article | 01/21/2010 |
| we investigated the role of hMI-ER1alpha and hMI-ER1beta in the regulation of transcription.We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1). | Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.
Ding Z, Gillespie LL, Paterno GD., Free PMC Article | 01/21/2010 |
| the association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters | The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter.
Ding Z, Gillespie LL, Mercer FC, Paterno GD. | 01/21/2010 |
| Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function. | Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization.
Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, Gillespie LL. | 01/21/2010 |