| A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis. | A genome-wide association study identified PTPN2 as a population-specific susceptibility gene locus for primary biliary cholangitis.
Hitomi Y, Ueno K, Aiba Y, Nishida N, Kono M, Sugihara M, Kawai Y, Kawashima M, Khor SS, Sugi K, Kouno H, Kohno H, Naganuma A, Iwamoto S, Katsushima S, Furuta K, Nikami T, Mannami T, Yamashita T, Ario K, Komatsu T, Makita F, Shimada M, Hirashima N, Yokohama S, Nishimura H, Sugimoto R, Komura T, Ota H, Kojima M, Nakamuta M, Fujimori N, Yoshizawa K, Mano Y, Takahashi H, Hirooka K, Tsuruta S, Sato T, Yamasaki K, Kugiyama Y, Motoyoshi Y, Suehiro T, Saeki A, Matsumoto K, Nagaoka S, Abiru S, Yatsuhashi H, Ito M, Kawata K, Takaki A, Arai K, Arinaga-Hino T, Abe M, Harada M, Taniai M, Zeniya M, Ohira H, Shimoda S, Komori A, Tanaka A, Ishigaki K, Nagasaki M, Tokunaga K, Nakamura M. | 10/11/2024 |
| Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus. | Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus.
Jeanpierre M, Cognard J, Tusseau M, Riller Q, Bui LC, Berthelet J, Laurent A, Crickx E, Parlato M, Stolzenberg MC, Suarez F, Leverger G, Aladjidi N, Collardeau-Frachon S, Pietrement C, Malphettes M, Froissart A, Bole-Feysot C, Cagnard N, Rodrigues Lima F, Walzer T, Rieux-Laucat F, Belot A, Mathieu AL., | 07/24/2024 |
| PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3. | PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3.
Liu S, Liu F, Zhang Z, Zhuang Z, Chen Y. | 02/23/2024 |
| Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity. | Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity.
Triolo TM, Matuschek JQ, Castro-Gutierrez R, Shilleh AH, Williams SPM, Hansen MS, McDaniel K, Barra JM, Michels A, Russ HA., Free PMC Article | 12/31/2022 |
| PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review. | PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review.
Song J, Lan J, Tang J, Luo N., Free PMC Article | 10/1/2022 |
| The first association study of Protein Tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) gene polymorphisms in Malaysian patients with Crohn's disease. | The first association study of Protein Tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) gene polymorphisms in Malaysian patients with Crohn's disease.
Goh XT, Fong SK, Chai HC, Kee BP, Chua KH. | 07/16/2022 |
| Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. | Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Nian Q, Berthelet J, Parlato M, Mechaly AE, Liu R, Dupret JM, Cerf-Bensussan N, Haouz A, Rodrigues Lima F., Free PMC Article | 07/9/2022 |
| PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic beta-Cells in Autoimmune Diabetes. | PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes.
Elvira B, Vandenbempt V, Bauzá-Martinez J, Crutzen R, Negueruela J, Ibrahim H, Winder ML, Brahma MK, Vekeriotaite B, Martens PJ, Singh SP, Rossello F, Lybaert P, Otonkoski T, Gysemans C, Wu W, Gurzov EN. | 05/14/2022 |
| PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer. | PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer.
Goh PK, Wiede F, Zeissig MN, Britt KL, Liang S, Molloy T, Goode N, Xu R, Loi S, Muller M, Humbert PO, McLean C, Tiganis T., Free PMC Article | 04/23/2022 |
| Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation. | Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Spalinger MR, Crawford M, Bobardt SD, Li J, Sayoc-Becerra A, Santos AN, Shawki A, Chatterjee P, Nair MG, McCole DF., Free PMC Article | 04/2/2022 |
| PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis. | PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis.
Kuang W, Wang X, Ding J, Li J, Ji M, Chen W, Wang L, Yang P., Free PMC Article | 03/5/2022 |
| Association of Variants in FCGR2A, PTPN2, and GM-CSF with Cerebral Cavernous Malformation: Potential Biomarkers for a Symptomatic Disease. | Association of Variants in FCGR2A, PTPN2, and GM-CSF with Cerebral Cavernous Malformation: Potential Biomarkers for a Symptomatic Disease.
da Fontoura Galváo G, Fontes-Dantas FL, da Silva EV, Alves-Leon SV, de Souza JM. | 02/26/2022 |
| The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1. | The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1.
Singh JP, Li Y, Chen YY, Hsu SD, Page R, Peti W, Meng TC., Free PMC Article | 01/29/2022 |
| Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix alpha7 in Phosphatase Activity. | Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity.
Singh JP, Lin MJ, Hsu SF, Peti W, Lee CC, Meng TC. | 01/15/2022 |
| Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn's Disease: On the Way to Personalized Medicine? | Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn's Disease: On the Way to Personalized Medicine?
Hoffmann P, Lamerz D, Hill P, Kirchner M, Gauss A., Free PMC Article | 12/18/2021 |
| Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP). | Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP).
Tang C, Feng W, Bao Y, Du H., Free PMC Article | 12/4/2021 |
| T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling. | T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Tremblay ML, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DF., Free PMC Article | 11/13/2021 |
| Proteasome regulation by reversible tyrosine phosphorylation at the membrane. | Proteasome regulation by reversible tyrosine phosphorylation at the membrane.
Chen L, Zhang Y, Shu X, Chen Q, Wei T, Wang H, Wang X, Wu Q, Zhang X, Liu X, Zheng S, Huang L, Xiao J, Jiang C, Yang B, Wang Z, Guo X., Free PMC Article | 10/16/2021 |
| Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development. | Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development.
Katkeviciute E, Hering L, Montalban-Arques A, Busenhart P, Schwarzfischer M, Manzini R, Conde J, Atrott K, Lang S, Rogler G, Naschberger E, Schellerer VS, Stürzl M, Rickenbacher A, Turina M, Weber A, Leibl S, Leventhal GE, Levesque M, Boyman O, Scharl M, Spalinger MR., Free PMC Article | 09/11/2021 |
| Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics. | Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
Vinette V, Aubry I, Insull H, Uetani N, Hardy S, Tremblay ML. | 07/17/2021 |
| Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. | Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms.
Keindl M, Fedotkina O, du Plessis E, Jain R, Bergum B, Mygind Jensen T, Laustrup Møller C, Falhammar H, Nyström T, Catrina SB, Jörneskog G, Groop L, Eliasson M, Eliasson B, Brismar K, Nilsson PM, Berg TJ, Appel S, Lyssenko V., Free PMC Article | 06/5/2021 |
| PTPN2 negatively regulates macrophage inflammation in atherosclerosis. | PTPN2 negatively regulates macrophage inflammation in atherosclerosis.
Hu X, Ma R, Cao J, Du X, Cai X, Fan Y., Free PMC Article | 05/22/2021 |
| Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases. | Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases.
Hongdusit A, Fox JM. | 05/15/2021 |
| PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function. | PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.
Spalinger MR, Sayoc-Becerra A, Santos AN, Shawki A, Canale V, Krishnan M, Niechcial A, Obialo N, Scharl M, Li J, Nair MG, McCole DF., Free PMC Article | 04/17/2021 |
| Inflammatory response or oxidative stress induces upregulation of PTPN2 and thus promotes the progression of laryngocarcinoma. | Inflammatory response or oxidative stress induces upregulation of PTPN2 and thus promotes the progression of laryngocarcinoma.
Yang HJ, Yu G, Wang Y, Guo X. | 04/3/2021 |