| Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer, Especially in Hypoxic Environments. | Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer, Especially in Hypoxic Environments.
Masuda S, Onishi H, Iwamoto N, Imaizumi A, Koga S, Nagao S, Sakanashi K, Itoyama S, Fujimura A, Komune N, Kogo R, Umebayashi M, Morisaki T, Nakagawa T. | 03/7/2024 |
| Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy. | Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy.
Zhou Z, Lin Z, Wang M, Wang L, Ji Y, Yang J, Yang Y, Zhu G, Liu T., Free PMC Article | 01/8/2024 |
| PTPN3 Could Betae a Therapeutic Target of Pancreatic Cancer. | PTPN3 Could Βe a Therapeutic Target of Pancreatic Cancer.
Onishi H, Iwamoto N, Sakanashi K, Koga S, Oyama Y, Yanai K, Nakamura K, Nagai S, Fujimura A, Nakayama K, Ozono K, Yamasaki A. | 06/11/2022 |
| Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein. | Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Genera M, Quioc-Salomon B, Nourisson A, Colcombet-Cazenave B, Haouz A, Mechaly A, Matondo M, Duchateau M, König A, Windisch MP, Neuveut C, Wolff N, Caillet-Saguy C., Free PMC Article | 08/21/2021 |
| PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling. | PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
Peng XS, Yang JP, Qiang YY, Sun R, Cao Y, Zheng LS, Peng LX, Lang YH, Mei Y, Li CZ, Meng DF, Liu ZJ, Wang MD, Zhou FJ, Huang BJ, Qian CN. | 06/5/2021 |
| NFkappaB and TGFbeta contribute to the expression of PTPN3 in activated human lymphocytes. | NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes.
Nakayama K, Onishi H, Fujimura A, Imaizumi A, Kawamoto M, Oyama Y, Ichimiya S, Koga S, Fujimoto Y, Nakashima K, Nakamura M. | 03/13/2021 |
| Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein. | Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.
Genera M, Samson D, Raynal B, Haouz A, Baron B, Simenel C, Guerois R, Wolff N, Caillet-Saguy C., Free PMC Article | 11/21/2020 |
| PTPN3 suppressed the proliferation of perihilar cholangiocarcinoma by inhibiting AKT phosphorylation and arresting cell cycle. | PTPN3 suppresses the proliferation and correlates with favorable prognosis of perihilar cholangiocarcinoma by inhibiting AKT phosphorylation.
Sun R, Chen T, Li M, Liu Z, Qiu B, Li Z, Xu Y, Pan C, Zhang Z. | 06/6/2020 |
| Low PTPN3 expression is associated with gastric cancer angiogenesis. | MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3).
Zhang S, Zhang R, Xu R, Shang J, He H, Yang Q. | 02/29/2020 |
| findings reveal a novel mechanism by which reversible tyrosine phosphorylation of DAAM1 by Src and PTPN3 regulates actin dynamics and lung cancer invasivenes | PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization.
Li MY, Peng WH, Wu CH, Chang YM, Lin YL, Chang GD, Wu HC, Chen GC. | 02/29/2020 |
| Study reports that PTPN3 suppresses liver cancer progression through positively regulating TGF-b signaling. Furthermore, the recurrent L232R mutation in liver cancer disables its role in enhancing TGF-beta signaling and abolishes its tumor-suppressive function. | PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity.
Yuan B, Liu J, Cao J, Yu Y, Zhang H, Wang F, Zhu Y, Xiao M, Liu S, Ye Y, Ma L, Xu D, Xu N, Li Y, Zhao B, Xu P, Jin J, Xu J, Chen X, Shen L, Lin X, Feng XH., Free PMC Article | 12/28/2019 |
| E6 oncoprotein of the betaHPV type 8-mediated targeting of PTPH1 might result in higher level of EGFR and enhanced keratinocyte proliferation. | The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene.
Taute S, Böhnke P, Sprissler J, Buchholz S, Hufbauer M, Akgül B, Steger G., Free PMC Article | 12/7/2019 |
| PTPH1 is upregulated in breast cancer from Indian population; its expression is correlative with ER, and PR status. The 2 kb region upstream of PTPH1 gene harbored CpG sites within, and was ubiquitously methylated in breast cancer. | PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study.
Venkatesh T, Shetty A, Chakraborti S, Suresh PS. | 12/7/2019 |
| High expression of PTPN3 was significantly associated with unfavorable prognosis of GBM. Moreover, in GBM cell lines, PTPN3 promoted cell proliferation and invasion, and the PTP common inhibitor pervanadate suppressed GBM proliferation and invasion. | High Expression of PTPN3 Predicts Progression and Unfavorable Prognosis of Glioblastoma.
Wang Y, Su Y, Ji Z, Lv Z., Free PMC Article | 12/29/2018 |
| PTPN3 promotes tumorigenicity, stemness and drug resistance in ovarian cancer. | Protein tyrosine phosphatase PTPN3 promotes drug resistance and stem cell-like characteristics in ovarian cancer.
Li S, Cao J, Zhang W, Zhang F, Ni G, Luo Q, Wang M, Tao X, Xia H., Free PMC Article | 05/26/2018 |
| Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR) signaling. | Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation.
Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, Meng TC, Chen GC. | 10/17/2015 |
| analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation | Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation.
Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC, Wang AH. | 06/27/2015 |
| These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1. | Protein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537.
Suresh PS, Ma S, Migliaccio A, Chen G. | 10/4/2014 |
| Activating mutations in and high expression levels of PTPN3 were associated with tumor recurrence in cholangiocarcinoma. | Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients.
Gao Q, Zhao YJ, Wang XY, Guo WJ, Gao S, Wei L, Shi JY, Shi GM, Wang ZC, Zhang YN, Shi YH, Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang H, Qiu ZP, Chen ZA, Zhang ZF, Qiu SJ, Zhou J, He XH, Fan J. | 06/7/2014 |
| p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. | p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G., Free PMC Article | 11/17/2012 |
| The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced. | Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing.
Jung Y, Kim P, Jung Y, Keum J, Kim SN, Choi YS, Do IG, Lee J, Choi SJ, Kim S, Lee JE, Kim J, Lee S, Kim J. | 09/29/2012 |
| PTPH1 stimulated breast cancer growth through regulating vitamin D receptor expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis. | PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization.
Zhi HY, Hou SW, Li RS, Basir Z, Xiang Q, Szabo A, Chen G., Free PMC Article | 06/25/2011 |
| PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma-binding activity. Ras increases p38gamma and PTPH1 expression and there is a coupling of increased p38gamma and PTPH1 protein expression in colon cancer. | PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.
Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G., Free PMC Article | 05/10/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
Vieira AR, McHenry TG, Daack-Hirsch S, Murray JC, Marazita ML., Free PMC Article | 11/17/2008 |
| PTP-H1 has a role in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion | Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.
Pilecka I, Patrignani C, Pescini R, Curchod ML, Perrin D, Xue Y, Yasenchak J, Clark A, Magnone MC, Zaratin P, Valenzuela D, Rommel C, Hooft van Huijsduijnen R. | 01/21/2010 |