| SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches. | SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches.
Wu Q, Tian P, He D, Jia Z, He Y, Luo W, Lv X, Wang Y, Zhang P, Liang Y, Zhao W, Qin J, Su P, Jiang YZ, Shao ZM, Yang Q, Hu G., Free PMC Article | 06/7/2023 |
| Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2. | Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2.
Wang R, Li H, Han Y, Li L. | 10/15/2022 |
| Expression of SCUBE2 and BCL2 Predicts Favorable Response in ERalpha Positive Breast Cancer. | Expression of SCUBE2 and BCL2 Predicts Favorable Response in ERα Positive Breast Cancer.
Esmaeili R, Mohammadi S, Jafarbeik-Iravani N, Yadegari F, Olfatbakhsh A, Mazaheri M, Kaviani A, Rezaee M, Majidzadeh-A K. | 11/13/2021 |
| Knockdown of long non-coding RNA PVT1 induces apoptosis of fibroblast-like synoviocytes through modulating miR-543-dependent SCUBE2 in rheumatoid arthritis. | Knockdown of long non-coding RNA PVT1 induces apoptosis of fibroblast-like synoviocytes through modulating miR-543-dependent SCUBE2 in rheumatoid arthritis.
Wang J, Kong X, Hu H, Shi S., Free PMC Article | 02/2/2021 |
| The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients. | The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.
Gündüz İ, Batmaz İ, Bozan T, Ekinci A, Cevik R. | 02/2/2021 |
| High SCUBE2 expression is associated with dyslipidemic type 2 diabetes mellitus. | Upregulation of SCUBE2 expression in dyslipidemic type 2 diabetes mellitus is associated with endothelin-1.
Ali H, Rustam R, Aprilia D, Arizal C, Gusadri IB, Utami PR. | 02/15/2020 |
| this study reported for the first time that SCUBE2 methylation can be reversed by (-)-epigallocatechin-3-gallate treatment, finally resulting in the inhibition of breast cancer progression. | The Inhibitory Effect of (-)-Epigallocatechin-3-Gallate on Breast Cancer Progression via Reducing SCUBE2 Methylation and DNMT Activity.
Sheng J, Shi W, Guo H, Long W, Wang Y, Qi J, Liu J, Xu Y., Free PMC Article | 01/11/2020 |
| that SCUBE2 expression is upregulated in breast cancer stem cells, promote EMT and enhance TNBC metastasis by activating Notch signaling | Upregulated SCUBE2 expression in breast cancer stem cells enhances triple negative breast cancer aggression through modulation of notch signaling and epithelial-to-mesenchymal transition.
Chen JH, Kuo KT, Bamodu OA, Lin YC, Yang RB, Yeh CT, Chao TY. | 10/5/2019 |
| Overexpression of SCUBE2 inhibits non-small cell lung cancer cell proliferation and invasion through suppressing the Sonic hedgehog signaling pathway. | SCUBE2 inhibits the proliferation, migration and invasion of human non-small cell lung cancer cells through regulation of the sonic hedgehog signaling pathway.
Yang B, Miao S, Li Y. | 07/21/2018 |
| Results confirm that heparan sulfate (HS) proteoglycans enrich Scube2 at the surface of Shh-producing cells and that Scube2-regulated proteolytic Shh processing and release depends on specific HS. | Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells.
Jakobs P, Schulz P, Ortmann C, Schürmann S, Exner S, Rebollido-Rios R, Dreier R, Seidler DG, Grobe K., Free PMC Article | 04/21/2018 |
| Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis. | Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis.
Lin YC, Chao TY, Yeh CT, Roffler SR, Kannagi R, Yang RB. | 06/24/2017 |
| The Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. | Overexpression of SCUBE2 Inhibits Proliferation, Migration, and Invasion in Glioma Cells.
Guo E, Liu H, Liu X., Free PMC Article | 03/25/2017 |
| Overexpression of SCUBE2 is associated with Breast Cancer Recurrence. | New Gene Profiling in Determination of Breast Cancer Recurrence and Prognosis in Iranian Women.
Poorhosseini SM, Hashemi M, Alipour Olyaei N, Izadi A, Moslemi E, Ravesh Z, Hashemi-Gorji F, Kheiri HR, Yassaee VR. | 02/18/2017 |
| SCUBE2 expression was decreased at the transcriptional and translational levels in colorectal cancer tissues and significantly associated with clinical stage, the depth of tumor invasion, lymphnode metastasis, distant metastasis and histological grade. | Decreased expression of SCUBE2 is associated with progression and prognosis in colorectal cancer.
Song Q, Li C, Feng X, Yu A, Tang H, Peng Z, Wang X. | 01/16/2016 |
| Sheddases and Scube2 act cooperatively to increase the pool of soluble bioactive Shh. | Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells.
Jakobs P, Exner S, Schürmann S, Pickhinke U, Bandari S, Ortmann C, Kupich S, Schulz P, Hansen U, Seidler DG, Grobe K. | 12/6/2014 |
| Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition. | Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition.
Lin YC, Lee YC, Li LH, Cheng CJ, Yang RB. | 08/23/2014 |
| data suggest that signal peptide CUB domain (SCUBE2), like in breast cancer, associates with estrogen receptor alpha and might have a potential as prognostic or predictive marker in endometrial cancer | Expression of SCUBE2 gene declines in high grade endometrial cancer and associates with expression of steroid hormone receptors and tumor suppressor PTEN.
Skrzypczak M, Lattrich C, Häring J, Schüler S, Ortmann O, Treeck O. | 06/14/2014 |
| Via obligate assistance of Scube1 and 3, Scube2 plays a center role to recruit dually lipid-modified Hedgehog transferred from Dispatched A (DispA), increasing Hh secretion by promoting its solubility. | Scube regulates synovial angiogenesis-related signaling.
Yang M, Guo M, Hu Y, Jiang Y. | 06/7/2014 |
| Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. | Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2.
Lin YC, Chen CC, Cheng CJ, Yang RB., Free PMC Article | 10/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q., Free PMC Article | 04/7/2010 |
| The full-length cDNA of human SCUBE2 was isolated and the role in the hedgehog signalling cascade, was studied. | Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans.
Tsai MT, Cheng CJ, Lin YC, Chen CC, Wu AR, Wu MT, Hsu CC, Yang RB. | 01/21/2010 |
| Altered SCUBE2 expression is important in breast cancer progression and SCUBE2 may serve as a useful prognostic marker. | SCUBE2 suppresses breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer.
Cheng CJ, Lin YC, Tsai MT, Chen CS, Hsieh MC, Chen CL, Yang RB. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGenetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. | 09/24/2008 |
| identification as secreted protein that is expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis | Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.
Yang RB, Ng CK, Wasserman SM, Colman SD, Shenoy S, Mehraban F, Komuves LG, Tomlinson JE, Topper JN. | 01/21/2010 |