| Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids. | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Miller MS, Cowan AD, Brouwer JM, Smyth ST, Peng L, Wardak AZ, Uren RT, Luo C, Roy MJ, Shah S, Tan Z, Reid GE, Colman PM, Czabotar PE. | 10/21/2024 |
| Lipid unsaturation promotes BAX and BAK pore activity during apoptosis. | Lipid unsaturation promotes BAX and BAK pore activity during apoptosis.
Dadsena S, Cuevas Arenas R, Vieira G, Brodesser S, Melo MN, García-Sáez AJ., Free PMC Article | 10/4/2024 |
| RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis. | RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis.
Guan Z, Li H, Zhang C, Huang Z, Ye M, Zhang Y, Li S, Peng K., Free PMC Article | 09/5/2024 |
| Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria. | Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria.
Schweighofer SV, Jans DC, Keller-Findeisen J, Folmeg A, Ilgen P, Bates M, Jakobs S., Free PMC Article | 04/26/2024 |
| Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak. | Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak.
Sovilj D, Kelemen CD, Dvorakova S, Zobalova R, Raabova H, Kriska J, Hermanova Z, Knotek T, Anderova M, Klener P, Filimonenko V, Neuzil J, Andera L. | 02/20/2024 |
| Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunctiondagger. | Dysregulation of MTFR2, ATP5IF1 and BAK1 in Sertoli cells relates to idiopathic non-obstructive azoospermia via inhibiting mitochondrial fission and inducing mitochondrial dysfunction†.
Wei L, Feng Z, Dou Q, Tan L, Zhao X, Hao B. | 02/20/2024 |
| Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia. | Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia.
Zhou J, Zhao Y, An P, Zhao H, Li X, Xiong Y., Free PMC Article | 08/14/2023 |
| Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignancies. | Decoding the concealed transcriptional signature of the apoptosis-related BCL2 antagonist/killer 1 (BAK1) gene in human malignancies.
Athanasopoulou K, Adamopoulos PG, Daneva GN, Scorilas A. | 11/5/2022 |
| A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors. | A common deletion at BAK1 reduces enhancer activity and confers risk of intracranial germ cell tumors.
Sonehara K, Kimura Y, Nakano Y, Ozawa T, Takahashi M, Suzuki K, Fujii T, Matsushita Y, Tomiyama A, Kishikawa T, Yamamoto K, Naito T, Suzuki T, Yamaguchi S, Miwa T, Sasaki H, Kitagawa M, Ohe N, Fukai J, Ogiwara H, Kawamura A, Miyawaki S, Matsuda F, Kiyokawa N, Ichimura K, Nishikawa R, Okada Y, Terashima K., Free PMC Article | 08/13/2022 |
| The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. | The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation.
Cosentino K, Hertlein V, Jenner A, Dellmann T, Gojkovic M, Peña-Blanco A, Dadsena S, Wajngarten N, Danial JSH, Thevathasan JV, Mund M, Ries J, Garcia-Saez AJ., Free PMC Article | 04/30/2022 |
| Bak interacts with AKT and is involved in TNFalpha/CHX-induced apoptosis. | Bak interacts with AKT and is involved in TNFα/CHX-induced apoptosis.
Song J, Zhang F, Wang Y, Wang Y, Zhang J, Xiao Z, Fu X, Xu X, Zeng L. | 03/26/2022 |
| Structural basis of BAK activation in mitochondrial apoptosis initiation. | Structural basis of BAK activation in mitochondrial apoptosis initiation.
Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T., Free PMC Article | 02/12/2022 |
| Paradoxical implication of BAX/BAK in the persistence of tetraploid cells. | Paradoxical implication of BAX/BAK in the persistence of tetraploid cells.
Deng J, Gutiérrez LG, Stoll G, Motiño O, Martins I, Núñez L, Bravo-San Pedro JM, Humeau J, Bordenave C, Pan J, Fohrer-Ting H, Souquere S, Pierron G, Hetz C, Villalobos C, Kroemer G, Senovilla L., Free PMC Article | 02/5/2022 |
| Dynamic reconfiguration of pro-apoptotic BAK on membranes. | Dynamic reconfiguration of pro-apoptotic BAK on membranes.
Sandow JJ, Tan IK, Huang AS, Masaldan S, Bernardini JP, Wardak AZ, Birkinshaw RW, Ninnis RL, Liu Z, Dalseno D, Lio D, Infusini G, Czabotar PE, Webb AI, Dewson G., Free PMC Article | 12/18/2021 |
| High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane. | High-resolution analysis of the conformational transition of pro-apoptotic Bak at the lipid membrane.
Sperl LE, Rührnößl F, Schiller A, Haslbeck M, Hagn F., Free PMC Article | 12/18/2021 |
| Inflammation-dependent downregulation of miR-532-3p mediates apoptotic signaling in human sarcopenia through targeting BAK1. | Inflammation-dependent downregulation of miR-532-3p mediates apoptotic signaling in human sarcopenia through targeting BAK1.
Chen FX, Shen Y, Liu Y, Wang HF, Liang CY, Luo M., Free PMC Article | 08/28/2021 |
| Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1. | Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1.
Dong L, Vaux DL., Free PMC Article | 04/17/2021 |
| SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation. | SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.
Li S, Li H, Zhang YL, Xin QL, Guan ZQ, Chen X, Zhang XA, Li XK, Xiao GF, Lozach PY, Cui J, Liu W, Zhang LK, Peng K. | 03/27/2021 |
| Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. | Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma.
Guttà C, Rahman A, Aura C, Dynoodt P, Charles EM, Hirschenhahn E, Joseph J, Wouters J, de Chaumont C, Rafferty M, Warren M, van den Oord JJ, Gallagher WM, Rehm M., Free PMC Article | 03/13/2021 |
| Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis. | Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis.
Qin J, Yang Y, Zhuang X, Xing J., Free PMC Article | 02/6/2021 |
| BAK core dimers bind lipids and can be bridged by them. | BAK core dimers bind lipids and can be bridged by them.
Cowan AD, Smith NA, Sandow JJ, Kapp EA, Rustam YH, Murphy JM, Brouwer JM, Bernardini JP, Roy MJ, Wardak AZ, Tan IK, Webb AI, Gulbis JM, Smith BJ, Reid GE, Dewson G, Colman PM, Czabotar PE. | 02/2/2021 |
| Co-expression of Mcl-1 and Bak induces mitochondrial swelling. | Co-expression of Mcl-1 and Bak induces mitochondrial swelling.
Wang Y, Su W, Mai Z, Du M, Yu S, Liu Y, Wang X, Chen T. | 01/16/2021 |
| Structure-based modeling of turnover of Bcl-2 family proteins bound to voltage-dependent anion channel 2 (VDAC2): Implications for the mechanisms of proapoptotic activation of Bak and Bax in vivo. | Structure-based modeling of turnover of Bcl-2 family proteins bound to voltage-dependent anion channel 2 (VDAC2): Implications for the mechanisms of proapoptotic activation of Bak and Bax in vivo.
Dudko HV, Urban VA, Davidovskii AI, Veresov VG. | 01/9/2021 |
| It is distinct from the canonical pathways mediating platelet procoagulant function by strong physiologic stimuli or by the platelet apoptotic-like Bak/Bax-mediated pathway for cellular clearance. | CD36 and ERK5 link dyslipidemia to apoptotic-like platelet procoagulant function.
Yang M, Silverstein RL., Free PMC Article | 09/19/2020 |
| Characterization of an alternative BAK-binding site for BH3 peptides. | Characterization of an alternative BAK-binding site for BH3 peptides.
Ye K, Meng WX, Sun H, Wu B, Chen M, Pang YP, Gao J, Wang H, Wang J, Kaufmann SH, Dai H., Free PMC Article | 09/5/2020 |