| Dual role of GRHL3 in bladder carcinogenesis depending on histological subtypes. | Dual role of GRHL3 in bladder carcinogenesis depending on histological subtypes.
Lammert FC, Pannhausen J, Noetzel E, Friedland F, Wirtz J, Herfs Y, Leypold S, Gan L, Weiskirchen R, Schnitzler T, Knüchel R, Maurer J, Jonigk DD, Rose M, Gaisa NT., Free PMC Article | 06/18/2024 |
| The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750. | The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750.
Hu XT, Wu XF, Sui LM, Ao LQ, Pu CX, Yuan M, Xing W, Xu X. | 04/18/2024 |
| A Comprehensive Genetic Analysis of Slovenian Families with Multiple Cases of Orofacial Clefts Reveals Novel Variants in the Genes IRF6, GRHL3, and TBX22. | A Comprehensive Genetic Analysis of Slovenian Families with Multiple Cases of Orofacial Clefts Reveals Novel Variants in the Genes IRF6, GRHL3, and TBX22.
Slavec L, Geršak K, Eberlinc A, Hovnik T, Lovrečić L, Mlinarič-Raščan I, Karas Kuželički N., Free PMC Article | 03/15/2023 |
| Association analysis of SNPs in GRHL3, FAF1, and KCNJ2 with NSCPO sub-phenotypes in Han Chinese. | Association analysis of SNPs in GRHL3, FAF1, and KCNJ2 with NSCPO sub-phenotypes in Han Chinese.
Sun JL, Shi JY, Yin B, Lin YS, Shi B, Jia ZL. | 10/15/2022 |
| Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate. | Novel GRHL3 Variants in a South African Cohort With Cleft Lip and Palate.
Naicker T, Adeleke CC, Alade A, Mossey PA, Awotoye WA, Busch TD, Li M, Olotu J, Gowans LJJ, Aldous C, Butali A., Free PMC Article | 09/3/2022 |
| GRHL3 Promotes Tumor Growth and Metastasis via the MEK Pathway in Colorectal Cancer. | GRHL3 Promotes Tumor Growth and Metastasis via the MEK Pathway in Colorectal Cancer.
Tan L, Qu W, Wu D, Liu M, Wang Q, Ai Q, Hu H, Chen M, Chen W, Zhou H., Free PMC Article | 04/2/2022 |
| Genetic markers for non-syndromic orofacial clefts in populations of European ancestry: a meta-analysis. | Genetic markers for non-syndromic orofacial clefts in populations of European ancestry: a meta-analysis.
Slavec L, Karas Kuželički N, Locatelli I, Geršak K., Free PMC Article | 03/12/2022 |
| The functional GRHL3-filaggrin axis maintains a tumor differentiation potential and influences drug sensitivity. | The functional GRHL3-filaggrin axis maintains a tumor differentiation potential and influences drug sensitivity.
Bai Y, Zhao Z, Boath J, van Denderen BJ, Darido C., Free PMC Article | 02/5/2022 |
| Grainyhead-Like 3 Influences Migration and Invasion of Urothelial Carcinoma Cells. | Grainyhead-Like 3 Influences Migration and Invasion of Urothelial Carcinoma Cells.
Wezel F, Lustig J, Azoitei A, Liu J, Meessen S, Najjar G, Zehe V, Faustmann P, Zengerling F, John A, Martini T, Bolenz C, Günes C., Free PMC Article | 05/1/2021 |
| Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration. | Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.
Chen X, Lloyd SM, Kweon J, Gamalong GM, Bao X., Free PMC Article | 02/6/2021 |
| In the case-control study, significant associations were found between C27G genetic variants on rs2486668 and risk for spina bifida and encephalocele, respectively, under different genetic models. GG genotype on rs2486668 was associated with increased risk for spina bifida, with a RR of 2.15 (95% CI: 1.20-3.83).The GRHL3 C67G missense variant may increase the risk for spina bifida and encephalocele phenotypes. | Genetic variants in GRHL3 and risk for neural tube defects: A case-control and case-parent triad/control study.
Yang W, Xiao Y, Tian T, Jin L, Wang L, Ren A. | 08/29/2020 |
| Deletion of the transcription factor GRHL3 in the skin initiates a chemokine responsive signal leading to keratinocytes hyperproliferation and a pro-tumorigenic state. | Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis.
Goldie SJ, Cottle DL, Tan FH, Roslan S, Srivastava S, Brady R, Partridge DD, Auden A, Smyth IM, Jane SM, Dworkin S, Darido C., Free PMC Article | 12/14/2019 |
| We identified rare damaging variants in four genes known to be mutated in syndromic lip and/or cleft palate (syCL/P) : TP63 (one family), TBX1 (one family), LRP6 (one family) and GRHL3 (two families), and clinical reassessment confirmed the isolated nature of their lip and/or cleft palate (CL/P). | Whole exome sequencing identifies mutations in 10% of patients with familial non-syndromic cleft lip and/or palate in genes mutated in well-known syndromes.
Basha M, Demeer B, Revencu N, Helaers R, Theys S, Bou Saba S, Boute O, Devauchelle B, Francois G, Bayet B, Vikkula M. | 10/5/2019 |
| Hypomethylation of GRHL3 in central nervous tissue is associated with neural tube defects. | Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects.
Tian T, Wang L, Shen Y, Zhang B, Finnell RH, Ren A., Free PMC Article | 06/29/2019 |
| Grainyhead-like 3 transcription factor is phosphorylated at many residues in cells. Cleft palate associated single nucleotide polymorphism abolishes threonine 454 phosphorylation. This residue is phosphorylated by the p38 MAP kinase. Threonine 454 is essential for regulation of GRHL3 activity by the p38 pathway. | Threonine 454 phosphorylation in Grainyhead-like 3 is important for its function and regulation by the p38 MAPK pathway.
Krzywinska E, Zorawski MD, Taracha A, Kotarba G, Kikulska A, Mlacki M, Kwiatkowska K, Wilanowski T. | 03/16/2019 |
| Non-melanoma skin cancer growth is accompanied by coordinated reduced expression of epidermal differentiation genes: GRHL1 and GRHL3, which may be regulated by miR-21-3p and -5p, respectively. Some potentially damaging single nucleotide polymorphisms in GRHL genes occur with altered frequencies in NMSC patients, and they may in particular impair the expression of GRHL3 gene or functioning of encoded protein | Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers.
Kikulska A, Rausch T, Krzywinska E, Pawlak M, Wilczynski B, Benes V, Rutkowski P, Wilanowski T., Free PMC Article | 08/18/2018 |
| The down-regulation of GRHL3 in vitro could inhibit colorectal cancer cell activity and trigger cell cycle arrest at G0/G1 phase and apoptosis. | Knockdown of GRHL3 inhibits activities and induces cell cycle arrest and apoptosis of human colorectal cancer cells.
Wang XK, Zhou FF, Tao HR, Wang X, Zhang C, Su F, Wang SP, Xu LH, Pan XK, Feng MH, Xie W. | 07/28/2018 |
| The data suggest that IRF6, TFAP2A, and GRHL3, among others, are shared in neural tube and orofacial development. | Shared molecular networks in orofacial and neural tube development.
Kousa YA, Mansour TA, Seada H, Matoo S, Schutte BC. | 06/2/2018 |
| Comparison of the variant rate between our cohort and the ExAC database identified a significant enrichment of deleterious variants in GRHL3 in the whole gene and the transactivation region in spina bifida patients. These data provide strong evidence for a role of GRHL3 as a predisposing factor to spina bifida and will help dissect the complex etiology and pathogenic mechanisms of these malformations | Rare deleterious variants in GRHL3 are associated with human spina bifida.
Lemay P, De Marco P, Emond A, Spiegelman D, Dionne-Laporte A, Laurent S, Merello E, Accogli A, Rouleau GA, Capra V, Kibar Z. | 02/24/2018 |
| mutations contribute to the risk of nonsyndromic cleft palate only in the African population | Loss-of-Function GRHL3 Variants Detected in African Patients with Isolated Cleft Palate.
Eshete MA, Liu H, Li M, Adeyemo WL, Gowans LJJ, Mossey PA, Busch T, Deressa W, Donkor P, Olaitan PB, Aregbesola BS, Braimah RO, Oseni GO, Oginni F, Audu R, Onwuamah C, James O, Augustine-Akpan E, Rahman LA, Ogunlewe MO, Arthur FKN, Bello SA, Agbenorku P, Twumasi P, Abate F, Hailu T, Demissie Y, Hailu A, Plange-Rhule G, Obiri-Yeboah S, Dunnwald MM, Gravem PE, Marazita ML, Adeyemo AA, Murray JC, Cornell RA, Butali A., Free PMC Article | 01/13/2018 |
| All of these processes involve epithelial-mesencyhmal transition (EMT), MET or a sequence of both, suggesting that the GRHL factors((GRHL1, GRHL2 and GRHL3), could potentially affect tumor initiation and progression via EMT | Roles of Grainyhead-like transcription factors in cancer.
Frisch SM, Farris JC, Pifer PM. | 11/26/2017 |
| No association found between two GRHL3 SNPs (rs2486668 and rs545809) and non-syndromic orofacial clefts in the Han Chinese cohort. | Lack of Association between Missense Variants in GRHL3 (rs2486668 and rs545809) and Susceptibility to Non-Syndromic Orofacial Clefts in a Han Chinese Population.
He M, Bian Z., Free PMC Article | 07/29/2017 |
| ey epidermal differentiation transcription factor genes, including GRHL3, are located within super-enhancers, and many of these transcription factors in turn bind to and regulate super-enhancers. | GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states.
Klein RH, Lin Z, Hopkin AS, Gordon W, Tsoi LC, Liang Y, Gudjonsson JE, Andersen B., Free PMC Article | 06/3/2017 |
| GRHL3 expression may be useful as a prognostic factor. | Clinical significance of GRHL3 expression in diffuse large B cell lymphoma.
Liu W, Ha M, Wang X, Yin N. | 02/18/2017 |
| Study genotyped 10 tag SNPs covering GRHL3 and performed association analysis with nonsyndromic cleft lip with or without cleft palate in 504 cases and 455 healthy controls; preliminary results identified rs10903078, rs4638975, and a haplotype rs10903078-rs6659209 of GRHL3 that exceeded the significance threshold (p<0.05), though none survived Bonferroni correction for multiple comparisons. | Association study between Van der Woude Syndrome causative gene GRHL3 and nonsyndromic cleft lip with or without cleft palate in a Chinese cohort.
Wang Y, Sun Y, Huang Y, Pan Y, Jia Z, Ma L, Ma L, Lan F, Zhou Y, Shi J, Yang X, Zhang L, Jiang H, Jiang M, Yin A, Cheng J, Wang L, Yang Y, Shi B. | 01/28/2017 |