| HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14. | HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
Blakely WJ, Hatterschide J, White EA., Free PMC Article | 10/29/2024 |
| PTPN14 aggravates neointimal hyperplasia via boosting PDGFRbeta signaling in smooth muscle cells. | PTPN14 aggravates neointimal hyperplasia via boosting PDGFRβ signaling in smooth muscle cells.
Ma Q, He X, Wang X, Zhao G, Zhang Y, Su C, Wei M, Zhang K, Liu M, Zhu Y, He J., Free PMC Article | 10/4/2024 |
| circPTPN14 promotes renal fibrosis through its interaction with FUBP1 to enhance MYC transcription. | circPTPN14 promotes renal fibrosis through its interaction with FUBP1 to enhance MYC transcription.
Zhou JK, Li J, Peng Y., Free PMC Article | 04/7/2023 |
| PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR pathway. | PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR pathway.
Li H, Guan B, Liu S, Liu H, Song L, Zhang G, Zhao R, Zhou C, Gao P., Free PMC Article | 03/21/2023 |
| Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct Pathways of Molecular Pathogenesis. | Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct Pathways of Molecular Pathogenesis.
Russell-Goldman E, Dong F, Hanna J. | 07/23/2022 |
| Association of mutation in PTPN14 gene and gingival fibromatosis with distinctive facies: a novel finding in whole exome sequencing. | Association of mutation in PTPN14 gene and gingival fibromatosis with distinctive facies: a novel finding in whole exome sequencing.
Cogulu O, Mojarrab N, Simsir OS, Durmaz A, Aykut A, Cogulu D. | 12/25/2021 |
| PTPN14, a target gene of miR-4295, restricts the growth and invasion of osteosarcoma cells through inactivation of YAP1 signalling. | PTPN14, a target gene of miR-4295, restricts the growth and invasion of osteosarcoma cells through inactivation of YAP1 signalling.
Liang G, Duan C, He J, Ma W, Dai X. | 10/16/2021 |
| Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk. | Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk.
Olafsdottir T, Stacey SN, Sveinbjornsson G, Thorleifsson G, Norland K, Sigurgeirsson B, Thorisdottir K, Kristjansson AK, Tryggvadottir L, Sarin KY, Benediktsson R, Jonasson JG, Sigurdsson A, Jonasdottir A, Kristmundsdottir S, Jonsson H, Gylfason A, Oddsson A, Fridriksdottir R, Gudjonsson SA, Zink F, Lund SH, Rognvaldsson S, Melsted P, Steinthorsdottir V, Gudmundsson J, Mikaelsdottir E, Olason PI, Stefansdottir L, Eggertsson HP, Halldorsson BV, Thorsteinsdottir U, Agustsson TT, Olafsson K, Olafsson JH, Sulem P, Rafnar T, Gudbjartsson DF, Stefansson K. | 09/18/2021 |
| PTPN14 acts as a candidate tumor suppressor in prostate cancer and inhibits cell proliferation and invasion through modulating LATS1/YAP signaling. | PTPN14 acts as a candidate tumor suppressor in prostate cancer and inhibits cell proliferation and invasion through modulating LATS1/YAP signaling.
Wang R, Du Y, Shang J, Dang X, Niu G. | 07/17/2021 |
| PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy. | PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
Lin Y, Shao Z, Zhao M, Li J, Xu X. | 06/26/2021 |
| microRNA-217 suppressed epithelial-to-mesenchymal transition through targeting PTPN14 in gastric cancer. | microRNA-217 suppressed epithelial-to-mesenchymal transition through targeting PTPN14 in gastric cancer.
Chen G, Yang Z, Feng M, Wang Z., Free PMC Article | 03/20/2021 |
| Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. | Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation.
Fu P, Ramchandran R, Shaaya M, Huang L, Ebenezer DL, Jiang Y, Komarova Y, Vogel SM, Malik AB, Minshall RD, Du G, Tonks NK, Natarajan V., Free PMC Article | 12/26/2020 |
| A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation. | A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation.
Hatterschide J, Brantly AC, Grace M, Munger K, White EA., Free PMC Article | 12/5/2020 |
| Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration. | Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration.
Po'uha ST, Le Grand M, Brandl MB, Gifford AJ, Goodall GJ, Khew-Goodall Y, Kavallaris M., Free PMC Article | 10/24/2020 |
| Exosomal CircPRRX1 Enhances Doxorubicin Resistance in Gastric Cancer by Regulating MiR-3064-5p/PTPN14 Signaling. | Exosomal CircPRRX1 Enhances Doxorubicin Resistance in Gastric Cancer by Regulating MiR-3064-5p/PTPN14 Signaling.
Wang S, Ping M, Song B, Guo Y, Li Y, Jia J., Free PMC Article | 09/19/2020 |
| Nonreceptor tyrosine phosphatase 14 promotes proliferation and migration through regulating phosphorylation of YAP of Hippo signaling pathway in gastric cancer cells. | Nonreceptor tyrosine phosphatase 14 promotes proliferation and migration through regulating phosphorylation of YAP of Hippo signaling pathway in gastric cancer cells.
Han X, Sun T, Hong J, Wei R, Dong Y, Huang D, Chen J, Ren X, Zhou H, Tian W, Jia Y. | 09/12/2020 |
| Results indicate the significance and therapeutic potential of the intermolecular interaction between HPV18 E7 and host protein tyrosine phosphatase non-receptor type 14 (PTPN14) in HPV-mediated cell transformation and tumorigenesis. | Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus.
Yun HY, Kim MW, Lee HS, Kim W, Shin JH, Kim H, Shin HC, Park H, Oh BH, Kim WK, Bae KH, Lee SC, Lee EW, Ku B, Kim SJ., Free PMC Article | 01/25/2020 |
| Overexpression of PTPN14 promotes Roquin2 degradation in a KLHL6-dependant manner by promoting interaction with KLHL6. PTPN14 negatively regulates the protein stability of Roquin2. | PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.
Choi J, Saraf A, Florens L, Washburn MP, Busino L., Free PMC Article | 11/9/2019 |
| PTPN14 degradation impairs keratinocyte differentiation and propose that this contributes to high-risk HPV E7-mediated oncogenic activity independent of RB1 inactivation. | PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis.
Hatterschide J, Bohidar AE, Grace M, Nulton TJ, Kim HW, Windle B, Morgan IM, Munger K, White EA., Free PMC Article | 05/25/2019 |
| MiR-4516 represents an independent negative prognostic factor in GBM patients and acts as a novel oncogene in GBM, which regulates the PTPN14/Hippo pathway. | miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma.
Cui T, Bell EH, McElroy J, Becker AP, Gulati PM, Geurts M, Mladkova N, Gray A, Liu K, Yang L, Liu Z, Fleming JL, Haque SJ, Barnholtz-Sloan JS, Ligon KL, Beroukhim R, Robe P, Chakravarti A., Free PMC Article | 05/4/2019 |
| p53 deficiency promotes Yap signaling and that PTPN14 and TP53 mutations are mutually exclusive in human cancers. | A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.
Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD., Free PMC Article | 11/4/2017 |
| study determined that high-risk E7 proteins target the proteolysis of the cellular protein tyrosine phosphatase PTPN14 and find that this activity is correlated with the retinoblastoma-independent transforming activity of E7 | High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation.
White EA, Münger K, Howley PM., Free PMC Article | 07/22/2017 |
| PTPN14 is classified as a potential tumor suppressor protein, and is very susceptible to HPV E7-induced proteasome-mediated degradation. | The PTPN14 Tumor Suppressor Is a Degradation Target of Human Papillomavirus E7.
Szalmás A, Tomaić V, Basukala O, Massimi P, Mittal S, Kónya J, Banks L., Free PMC Article | 05/20/2017 |
| The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 was responsible for the pathway association (P < 0.01),corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 with ER-negativity in case-only analysis after gene-level correction | Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium.
Zhang J, Yao S, Hu Q, Zhu Q, Liu S, Lunetta KL, Haddad SA, Yang N, Shen H, Hong CC, Sucheston-Campbell L, Ruiz-Narvaez EA, Bensen JT, Troester MA, Bandera EV, Rosenberg L, Haiman CA, Olshan AF, Palmer JR, Ambrosone CB., Free PMC Article | 05/20/2017 |
| PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells. | Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis.
Wang C, Zhang W, Yin MX, Hu L, Li P, Xu J, Huang H, Wang S, Lu Y, Wu W, Ho MS, Li L, Zhao Y, Zhang L. | 03/26/2016 |