| Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea. | Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea.
Kim KY, Kim MS, Lee YJ, Lee YA, Lee SY, Shin CH, Kim JH., Free PMC Article | 12/10/2022 |
| Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target. | Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target.
Garranzo-Asensio M, Solís-Fernández G, Montero-Calle A, García-Martínez JM, Fiuza MC, Pallares P, Palacios-Garcia N, García-Jiménez C, Guzman-Aranguez A, Barderas R. | 03/5/2022 |
| Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8. | Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8.
Kawasaki E, Oikawa Y, Okada A, Kanatsuna N, Kawamura T, Kikuchi T, Terasaki J, Miura J, Itoh Y, Hanafusa T., Free PMC Article | 02/5/2022 |
| PTPN12, PTPRN and PTPN18 were independent prognostic factors in Hepatocellular Carcinoma. | Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma.
Zhangyuan G, Yin Y, Zhang W, Yu W, Jin K, Wang F, Huang R, Shen H, Wang X, Sun B. | 08/18/2018 |
| E. coli GI724 strain emerged as a handy source of recombinant IA-2ic, achieving high levels of expression as a thioredoxin fusion protein, adequately validated and applicable to the development of innovative and cost-effective immunoassays for IA-2A detection in most laboratories. | Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.
Guerra LL, Faccinetti NI, Trabucchi A, Rovitto BD, Sabljic AV, Poskus E, Iacono RF, Valdez SN., Free PMC Article | 06/24/2017 |
| Identification of amino acids contributing to distinct epitopes on IA-2, with both HLA-DR and HLA-DQ alleles influencing epitope specificity. | Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.
Richardson CC, McLaughlin KA, Morgan D, Feltbower RG, Christie MR., Free PMC Article | 10/22/2016 |
| RESP18HD is required for efficient sorting of ICA512 to secretory granules: RESP18HD is a key determinant for ICA512 granule targeting. | Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain.
Sosa L, Torkko JM, Primo ME, Llovera RE, Toledo PL, Rios AS, Flecha FL, Trabucchi A, Valdez SN, Poskus E, Solimena M, Ermácora MR. | 06/28/2016 |
| The binding of CREB to the promoter region, -216 to +115, enhanced IA-2 transcription by more than fivefold. | The minimal promoter region of the dense-core vesicle protein IA-2: transcriptional regulation by CREB.
Cai T, Hirai H, Xu H, Notkins AL., Free PMC Article | 04/16/2016 |
| Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 antibodies versus those patients with negative auto-antibodies and GAD65+ auto-antibodies after simultaneous pancreas kidney transplantation. | Tyrosine-phosphatase and glutamate-decarboxylase antibodies after simultaneous pancreas kidney transplantation: do they have an impact on pancreas graft survival?
Rodelo-Haad C, Aguera ML, Martinez-Vaquera S, Pendon-Ruiz de Mier MV, Salmeron-Rodriguez MD, Esquivias E, Navarro MD, Rodriguez-Benot A, Aljama P. | 10/31/2015 |
| Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes. | Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.
Long AE, Gillespie KM, Aitken RJ, Goode JC, Bingley PJ, Williams AJ., Free PMC Article | 08/3/2013 |
| identification of cysteines that are critical for IA-2A binding of autoantibodies in patients with newly diagnosed type 1 diabetes | The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes.
Elvers KT, Geoghegan I, Shoemark DK, Lampasona V, Bingley PJ, Williams AJ., Free PMC Article | 03/9/2013 |
| the IA-2A autoantibody response in children is intense with rapid maturation against immunogenic epitopes and a strong association with diabetes development | IA-2 autoantibody affinity in children at risk for type 1 diabetes.
Krause S, Chmiel R, Bonifacio E, Scholz M, Powell M, Furmaniak J, Rees Smith B, Ziegler AG, Achenbach P. | 01/26/2013 |
| Letter: report lack of anti-IA2 autoantibodies in primary antiphospholipid syndrome. | Lack of anti-insulin, anti-GAD, and anti-IA2 autoantibodies in primary antiphospholipid syndrome.
de Carvalho JF, Caleiro MT. | 08/25/2012 |
| analysis of protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain | Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain.
Primo ME, Jakoncic J, Noguera ME, Risso VA, Sosa L, Sica MP, Solimena M, Poskus E, Ermácora MR., Free PMC Article | 04/14/2012 |
| ZnT8A, GADA and IA-2A are autoantibodies that may have a role in successful pancreas graft survival | Zinc transporter 8 autoantibodies increase the predictive value of islet autoantibodies for function loss of technically successful solitary pancreas transplant.
Occhipinti M, Lampasona V, Vistoli F, Bazzigaluppi E, Scavini M, Boggi U, Marchetti P, Bosi E. | 11/26/2011 |
| In families with type 1 diabetes, there was a female predominance and more family history of associated autoimmune diseases (AAIDs) in the group with AAIDs, and less frequent anti-IA-2 antibodies | Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.
Wägner AM, Santana A, Herńndez M, Wiebe JC, Nóvoa J, Mauricio D, T1DGC6., Free PMC Article | 11/5/2011 |
| Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). | Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles.
Bauerschlag DO, Ammerpohl O, Bräutigam K, Schem C, Lin Q, Weigel MT, Hilpert F, Arnold N, Maass N, Meinhold-Heerlein I, Wagner W. | 10/1/2011 |
| Studies indicate that T1DM can be detected by determining four autoantibodies, namely those antibodies against insulin, glutamic acid decarboxylase 65, insulinoma antigen (IA)-2 (ICA512) and the zinc transporter ZnT8. | Prediction and prevention of Type 1 diabetes mellitus.
Zhang L, Eisenbarth GS. | 07/23/2011 |
| Risk of autoantibody seroconversion among children followed in DPT-1 is age dependent | Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood.
Vehik K, Haller MJ, Beam CA, Schatz DA, Wherrett DK, Sosenko JM, Krischer JP, DPT-1 Study Group., Free PMC Article | 04/30/2011 |
| Data show that significantly increased expression of MCP-1, IL-2 and PTPR-N was observed in Tourette's syndrome cases. | Elevated expression of MCP-1, IL-2 and PTPR-N in basal ganglia of Tourette syndrome cases.
Morer A, Chae W, Henegariu O, Bothwell AL, Leckman JF, Kawikova I. | 01/22/2011 |
| T cells stimulated in vitro by the IA-2 epitope express IFN-gamma when restimulated by the similar rotavirus VP7 peptide. | Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens.
Honeyman MC, Stone NL, Falk BA, Nepom G, Harrison LC. | 03/29/2010 |
| Report a chimeric assay providing an efficient and economical technique to screen for islet autoantibodies reacting with IA-2 and ZnT8 in type 1 diabetes mellitus. | Triple chimeric islet autoantigen IA2-ZnT8WR to facilitate islet autoantibody determination.
Yu L, Liu Y, Miao D, Wenzlau J, Davidson H, Hutton J, Eisenbarth GS. | 03/15/2010 |
| The study identifies a region of IA-2 frequently recognised by antibodies in Type 1 diabetes and demonstrates that these responses are associated with T-cells secreting IL-10 in response to a neighbouring determinant. | Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes.
Weenink SM, Lo J, Stephenson CR, McKinney PA, Ananieva-Jordanova R, Rees Smith B, Furmaniak J, Tremble JM, Bodansky HJ, Christie MR. | 01/21/2010 |
| Inexpensive, nonradioactive method for the detection of autoantibodies cell-prepared PTPRN (also known as IA-2) in diabetics. | A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2.
Burbelo PD, Hirai H, Leahy H, Lernmark A, Ivarsson SA, Iadarola MJ, Notkins AL., Free PMC Article | 01/21/2010 |
| HLA class II alleles strongly influence the prevalence of IA-2A in type 1 diabetes. | Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2.
Williams AJ, Aitken RJ, Chandler MA, Gillespie KM, Lampasona V, Bingley PJ. | 01/21/2010 |