| Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. | Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development.
Bresciani E, Carrington B, Yu K, Kim EM, Zhen T, Guzman VS, Broadbridge E, Bishop K, Kirby M, Harper U, Wincovitch S, Dell'Orso S, Sartorelli V, Sood R, Liu P., Free PMC Article | 01/8/2022 |
| Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb. | Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb.
Huang Z, Chen K, Chi Y, Jin H, Li L, Zhang W, Xu J, Zhang Y., Free PMC Article | 08/28/2021 |
| Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects. | Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects.
Mazzola M, Pezzotta A, Fazio G, Rigamonti A, Bresciani E, Gaudenzi G, Pelleri MC, Saitta C, Ferrari L, Parma M, Fumagalli M, Biondi A, Cazzaniga G, Marozzi A, Pistocchi A., Free PMC Article | 05/1/2021 |
| Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration. | Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration.
Koth J, Wang X, Killen AC, Stockdale WT, Potts HG, Jefferson A, Bonkhofer F, Riley PR, Patient RK, Göttgens B, Mommersteeg MTM., Free PMC Article | 12/19/2020 |
| Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney. | Enrichment of hematopoietic stem/progenitor cells in the zebrafish kidney.
Kobayashi I, Kondo M, Yamamori S, Kobayashi-Sun J, Taniguchi M, Kanemaru K, Katakura F, Traver D., Free PMC Article | 11/21/2020 |
| Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development | CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish.
Bresciani E, Carrington B, Wincovitch S, Jones M, Gore AV, Weinstein BM, Sood R, Liu PP., Free PMC Article | 08/30/2014 |
| We propose that cohesin and CTCF have distinct functions in the regulation of runx1 during zebrafish embryogenesis. | Cohesin and CTCF differentially regulate spatiotemporal runx1 expression during zebrafish development.
Marsman J, O'Neill AC, Kao BR, Rhodes JM, Meier M, Antony J, Mönnich M, Horsfield JA. | 03/22/2014 |
| Morpholino knockdown of Myef2 or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis. | A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
van Riel B, Pakozdi T, Brouwer R, Monteiro R, Tuladhar K, Franke V, Bryne JC, Jorna R, Rijkers EJ, van Ijcken W, Andrieu-Soler C, Demmers J, Patient R, Soler E, Lenhard B, Grosveld F., Free PMC Article | 12/8/2012 |
| Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages. | Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression.
Jin H, Li L, Xu J, Zhen F, Zhu L, Liu PP, Zhang M, Zhang W, Wen Z., Free PMC Article | 08/4/2012 |
| hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta | Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells.
Lam EY, Hall CJ, Crosier PS, Crosier KE, Flores MV. | 09/20/2010 |
| in zebrafish adult HSCs can be formed without an intact runx1. | Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation.
Sood R, English MA, Belele CL, Jin H, Bishop K, Haskins R, McKinney MC, Chahal J, Weinstein BM, Wen Z, Liu PP., Free PMC Article | 05/3/2010 |
| Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development. | Cohesin-dependent regulation of Runx genes.
Horsfield JA, Anagnostou SH, Hu JK, Cho KH, Geisler R, Lieschke G, Crosier KE, Crosier PS. | 01/21/2010 |