| KIS counteracts PTBP2 and regulates alternative exon usage in neurons. | KIS counteracts PTBP2 and regulates alternative exon usage in neurons.
Moreno-Aguilera M, Neher AM, Mendoza MB, Dodel M, Mardakheh FK, Ortiz R, Gallego C., Free PMC Article | 05/8/2024 |
| Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching. | Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching.
Dawicki-McKenna JM, Felix AJ, Waxman EA, Cheng C, Amado DA, Ranum PT, Bogush A, Dungan LV, Maguire JA, Gagne AL, Heller EA, French DL, Davidson BL, Prosser BL., Free PMC Article | 05/19/2023 |
| Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants. | Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.
Mei H, Yin B, Yang W, Zhang J, Lu H, Qi X, Mei W, Zhang H, Zhang J., Free PMC Article | 04/2/2022 |
| LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis. | LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis.
Mo C, Huang B, Zhuang J, Jiang S, Guo S, Mao X., Free PMC Article | 02/19/2022 |
| SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. | SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
Kim JH, Jeong K, Li J, Murphy JM, Vukadin L, Stone JK, Richard A, Tran J, Gillespie GY, Flemington EK, Sobol RW, Lim SS, Ahn EE., Free PMC Article | 10/16/2021 |
| PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL1 dependent | PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL1 dependent.
Nandagopalan SR, Agatheeswaran S, Vadlamudi Y, Biswas S, Biswas G, Pattnayak NC, Chakraborty S. | 12/7/2019 |
| It has been established that PTBP1 and PTBP2 are members of a family of cryptic exon repressors. | PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.
Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC., Free PMC Article | 11/18/2017 |
| PTBP1 and PTBP2 impaired autoregulation of SRSF3 in oral squamous cell carcinoma cancer cells. | PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells.
Guo J, Jia J, Jia R., Free PMC Article | 08/13/2016 |
| Data show that polypyrimidine tract-binding proteins nPTB and ROD1 interact with mitochondrial tRNA(Thr) in the cytoplasm outside of mitochondria. | Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.
Marnef A, Jády BE, Kiss T., Free PMC Article | 07/16/2016 |
| In T98G glioma cells, the level of sumoylated PTBP2 was reduced compared to that of normal brain cells. Overall, this study shows that PTBP2 is posttranslationally modified by SUMO1. | Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1.
Han W, Wang L, Yin B, Peng X., Free PMC Article | 03/7/2015 |
| MALAT1 binds to SFPQ releasing PTBP2 from the SFPQ/PTBP2 complex, the increased SFPQ-detached PTBP2 promotes cell proliferation and migration in colorectal cancer. | Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex.
Ji Q, Zhang L, Liu X, Zhou L, Wang W, Han Z, Sui H, Tang Y, Wang Y, Liu N, Ren J, Hou F, Li Q., Free PMC Article | 10/11/2014 |
| Defining the multifunctional roles of PTB will contribute to the understanding of key regulatory events in gene expression. | New insights into functional roles of the polypyrimidine tract-binding protein.
Romanelli MG, Diani E, Lievens PM., Free PMC Article | 06/7/2014 |
| Changes in miR-223/PTBP2 pathway could contribute of abnormal splicing in chronic myeloid leukemia. | BCR-ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemia.
Agatheeswaran S, Singh S, Biswas S, Biswas G, Chandra Pattnayak N, Chakraborty S. | 09/21/2013 |
| Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein. | Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein.
Tang ZZ, Sharma S, Zheng S, Chawla G, Nikolic J, Black DL., Free PMC Article | 06/18/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| present fluorescence, NMR, and in vivo splicing data in support of a role of PTB in inducing RNA loops. We show that the RNA recognition motifs (RRMs) 3 and 4 of PTB can bind two distant pyrimidine tracts and bring their 5' and 3' ends in close proximity | RNA looping by PTB: Evidence using FRET and NMR spectroscopy for a role in splicing repression.
Lamichhane R, Daubner GM, Thomas-Crusells J, Auweter SD, Manatschal C, Austin KS, Valniuk O, Allain FH, Rueda D., Free PMC Article | 04/19/2010 |
| Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c. | hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c.
Paradis C, Cloutier P, Shkreta L, Toutant J, Klarskov K, Chabot B., Free PMC Article | 01/21/2010 |
| The nPTB proximal promoter, although rich in G+C content and presenting putative binding sites for the transcription factors Sp1, NF-1, NF-kB and Oct-1, lacks a typical TATA box. | Identification and analysis of the human neural polypyrimidine tract binding protein (nPTB) gene promoter region.
Romanelli MG, Lorenzi P, Morandi C. | 01/21/2010 |