| The M2 Protein of the Influenza A Virus Interacts with PEX19 to Facilitate Virus Replication by Disrupting the Function of Peroxisome. | The M2 Protein of the Influenza A Virus Interacts with PEX19 to Facilitate Virus Replication by Disrupting the Function of Peroxisome.
Liu T, Liang L, Zhao P, Lin W, Zhuang Y, Jiang L, Chen H, Li C., Free PMC Article | 08/31/2024 |
| Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif. | Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
Farelo MA, Korrou-Karava D, Brooks KF, Russell TA, Maringer K, Mayerhofer PU., Free PMC Article | 03/12/2022 |
| Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response. | Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response.
Khantisitthiporn O, Shue B, Eyre NS, Nash CW, Turnbull L, Whitchurch CB, Van der Hoek KH, Helbig KJ, Beard MR., Free PMC Article | 12/4/2021 |
| studies indicate that Pex3 and Pex19 can also facilitate sorting of certain membrane proteins to other cellular organelles, including the endoplasmic reticulum, lipid droplets, and mitochondria | The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions.
Jansen RLM, van der Klei IJ. | 12/14/2019 |
| The summarize recent insights into the biogenesis and function of Lipid droplets and peroxisomes with emphasis on the role of PEX19 in these processes. | Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19.
Schrul B, Schliebs W. | 03/30/2019 |
| Hnf4-induced lipotoxicity and accumulation of free fatty acids is the cause for mitochondrial damage in consequence of peroxisome loss in Pex19 mutants | Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants.
Bülow MH, Wingen C, Senyilmaz D, Gosejacob D, Sociale M, Bauer R, Schulze H, Sandhoff K, Teleman AA, Hoch M, Sellin J., Free PMC Article | 01/12/2019 |
| Thus, PEX19 and PEX3 peroxisome biogenesis factors provide an alternative posttranslational route for membrane insertion of the reticulon homology domain-containing proteins, implying that endoplasmic reticulum membrane shaping and peroxisome biogenesis may be coordinated. | The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane.
Yamamoto Y, Sakisaka T., Free PMC Article | 12/22/2018 |
| The results demonstrate an allosteric mechanism for the modulation of PEX19 function by farnesylation. | Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M., Free PMC Article | 11/17/2018 |
| that newly synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis | Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.
Schrul B, Kopito RR., Free PMC Article | 06/10/2017 |
| suggest a novel regulatory mechanism for peroxisome biogenesis through the interaction between Pex19p and PLA/AT-3 | Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N., Free PMC Article | 10/3/2015 |
| Thus within the cell, PEX3 is stabilized by PEX19 preventing PEX3 aggregation. | Association between the intrinsically disordered protein PEX19 and PEX3.
Hattula K, Hirschberg D, Kalkkinen N, Butcher SJ, Ora A., Free PMC Article | 04/18/2015 |
| PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. | Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway.
Yagita Y, Hiromasa T, Fujiki Y., Free PMC Article | 04/27/2013 |
| PEX3-PEX19 interaction is crucial for de novo formation of peroxisomes in peroxisome-deficient cells. | The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis.
Schmidt F, Dietrich D, Eylenstein R, Groemping Y, Stehle T, Dodt G. | 12/8/2012 |
| The Pex19p peptide contains a characteristic motif, consisting of the leucine triad (Leu18, Leu21, Leu22), and Phe29, which are critical for the Pex3p binding and peroxisome biogenesis. | Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
Sato Y, Shibata H, Nakatsu T, Nakano H, Kashiwayama Y, Imanaka T, Kato H., Free PMC Article | 01/15/2011 |
| The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle. | Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19.
Schmidt F, Treiber N, Zocher G, Bjelic S, Steinmetz MO, Kalbacher H, Stehle T, Dodt G., Free PMC Article | 09/6/2010 |
| data indicate a divided N-terminal and C-terminal structural arrangement in Pex19p, which is reminiscent of a similar division in the Pex5p receptor, to allow separation of cargo-targeting signal recognition and additional functions. | The peroxisomal receptor Pex19p forms a helical mPTS recognition domain.
Schueller N, Holton SJ, Fodor K, Milewski M, Konarev P, Stanley WA, Wolf J, Erdmann R, Schliebs W, Song YH, Wilmanns M., Free PMC Article | 08/30/2010 |
| N-terminal domain of Pex14, Pex14(N), adopts a three-helical fold. Pex5 and Pex19 ligand helices bind competitively to the same surface in Pex14(N) albeit with opposite directionality. | Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M., Free PMC Article | 01/21/2010 |
| targeting of hFis1 to peroxisomes and mitochondria are independent events and support a direct, Pex19p-dependent targeting of peroxisomal tail-anchored proteins. | Targeting of hFis1 to peroxisomes is mediated by Pex19p.
Delille HK, Schrader M., Free PMC Article | 01/21/2010 |
| either one or two tryptophan residues of Pex3p (Trp-104 and Trp-224) are directly involved in binding to Pex19p. | Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction.
Sato Y, Shibata H, Nakano H, Matsuzono Y, Kashiwayama Y, Kobayashi Y, Fujiki Y, Imanaka T, Kato H. | 01/21/2010 |
| PEX19 binds and stabilizes newly synthesized PMPs in the cytosol, binds to multiple PMP targeting signals (mPTSs), interacts with the hydrophobic domains of PMP targeting signals, and is essential for PMP targeting and import. | PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.
Jones JM, Morrell JC, Gould SJ., Free PMC Article | 01/21/2010 |
| Pex19p translocates the membrane peroxins from the cytosol to peroxisomes in an ATP- and Pex3p-dependent manner and then shuttles back to the cytosol | In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p.
Matsuzono Y, Fujiki Y. | 01/21/2010 |
| analysis of the PEX19-binding site of human adrenoleukodystrophy protein | Function of the PEX19-binding site of human adrenoleukodystrophy protein as targeting motif in man and yeast. PMP targeting is evolutionarily conserved.
Halbach A, Lorenzen S, Landgraf C, Volkmer-Engert R, Erdmann R, Rottensteiner H. | 01/21/2010 |
| Data suggest that Pex19p probably functions as a chaperone for membrane proteins and transports them to peroxisomes by anchoring to Pex3p using residues 12-73 and 40-131. | Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation.
Matsuzono Y, Matsuzaki T, Fujiki Y. | 01/21/2010 |
| human Pex19p domain architecture and activity | Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins.
Shibata H, Kashiwayama Y, Imanaka T, Kato H. | 01/21/2010 |
| Pex19p has a role in assembly of PTS-receptor docking complexes | Potential role for Pex19p in assembly of PTS-receptor docking complexes.
Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP. | 01/21/2010 |