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    PXN paxillin [ Homo sapiens (human) ]

    Gene ID: 5829, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.

    Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
    Weidner AE, Roy A, Vann K, Walczyk AC, Astapova O., Free PMC Article

    06/5/2024
    ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.

    ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
    Saikia BB, Bhowmick S, Malat A, Preetha Rani MR, Thaha A, Abdul-Muneer PM., Free PMC Article

    03/21/2024
    Paxillin phase separation promotes focal adhesion assembly and integrin signaling.

    Paxillin phase separation promotes focal adhesion assembly and integrin signaling.
    Liang P, Wu Y, Zheng S, Zhang J, Yang S, Wang J, Ma S, Zhang M, Gu Z, Liu Q, Jiang W, Xing Q, Wang B., Free PMC Article

    03/15/2024
    Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.

    Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.
    Zheng H, Tsunedomi R, Xu M, Zhang Y, Kishi H, Kobayashi S, Tomochika S, Nakajima M, Matsui H, Tokumitsu Y, Shindo Y, Iida M, Ioka T, Nagano H.

    02/14/2024
    Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.

    Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
    Zhang Y, Li N, Kobayashi S., Free PMC Article

    02/12/2024
    Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.

    Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
    Liu L, Liu X, Chen Y, Kong M, Zhang J, Jiang M, Zhou H, Yang J, Chen X, Zhang Z, Wu C, Jiang X, Zhang J.

    01/17/2024
    Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.

    Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.
    Kim NH, Lee CH, Lee AY., Free PMC Article

    01/11/2024
    Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.

    Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
    Zhang Y, Zheng H, Xu M, Maeda N, Tsunedomi R, Kishi H, Nagano H, Kobayashi S., Free PMC Article

    11/18/2023
    An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.

    An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
    Liang P, Zhang J, Wu Y, Zheng S, Xu Z, Yang S, Wang J, Ma S, Xiao L, Hu T, Jiang W, Huang C, Xing Q, Kundu M, Wang B., Free PMC Article

    11/7/2023
    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.

    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
    Bilgiç A, Ferahkaya H, Karagöz H, Kılınç İ, Energin VM.

    10/26/2023
    Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110beta/Vps34/Beclin1 pathway.

    Autophagy-related gene PXN as a prognostic marker: Promotion of ovarian cancer progression by suppressing the p110β/Vps34/Beclin1 pathway.
    Wu Q, Cui Z, Jiang S, Xia H, Liu L, You Y, Sun Y.

    07/19/2023
    Vinculin Y822 is an important determinant of ligand binding.

    Vinculin Y822 is an important determinant of ligand binding.
    DeWane G, Cronin NM, Dawson LW, Heidema C, DeMali KA., Free PMC Article

    06/22/2023
    Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway.

    Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway.
    Hefni E, Menon D, Ma T, Asiedu EB, Sultan A, Meiller T, Schneider A, Sodhi A, Montaner S., Free PMC Article

    06/15/2023
    The Role of Paxillin Aberrant Expression in Cancer and Its Potential as a Target for Cancer Therapy.

    The Role of Paxillin Aberrant Expression in Cancer and Its Potential as a Target for Cancer Therapy.
    Liu W, Huang X, Luo W, Liu X, Chen W., Free PMC Article

    05/22/2023
    Programmed death ligand 1 intracellular interactions with STAT3 and focal adhesion protein Paxillin facilitate lymphatic endothelial cell remodeling.

    Programmed death ligand 1 intracellular interactions with STAT3 and focal adhesion protein Paxillin facilitate lymphatic endothelial cell remodeling.
    Schafer JB, Lucas ED, Dzieciatkowska M, Forward T, Tamburini BAJ., Free PMC Article

    03/8/2023
    LncRNA FIRRE promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the expression of PXN through interacting with MBNL3.

    LncRNA FIRRE promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the expression of PXN through interacting with MBNL3.
    Zhou J, Liu T, Xu H, Wang Y, Yang T, Liu L.

    09/17/2022
    Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma.

    Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma.
    Tanaka N, Minemura C, Asai S, Kikkawa N, Kinoshita T, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N., Free PMC Article

    02/19/2022
    Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss.

    Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss.
    Fu P, Epshtein Y, Ramchandran R, Mascarenhas JB, Cress AE, Jacobson J, Garcia JGN, Natarajan V., Free PMC Article

    11/13/2021
    MiR-216b regulates the tumorigenesis of gastric cancer by targeting PXN.

    MiR-216b regulates the tumorigenesis of gastric cancer by targeting PXN.
    Liu X, Xu D, Xu X, Xue Q, Gao X, Tang C.

    11/6/2021
    Exploring the Mechanism of the miRNA-145/Paxillin Axis in Cell Metabolism During VEGF-A-Induced Corneal Angiogenesis.

    Exploring the Mechanism of the miRNA-145/Paxillin Axis in Cell Metabolism During VEGF-A-Induced Corneal Angiogenesis.
    Yang W, Yang Y, Wan S, Xu Y, Li J, Zhang L, Guo W, Zheng Y, Xiang Y, Xing Y., Free PMC Article

    10/2/2021
    Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.

    Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion.
    Alpha KM, Xu W, Turner CE., Free PMC Article

    08/28/2021
    Abnormal level of paxillin in cervical cancer cells is involved in tumor progression and invasion.

    Abnormal level of paxillin in cervical cancer cells is involved in tumor progression and invasion.
    Gu H, Wen J.

    07/31/2021
    Pan-cancer analysis reveals an immunological role and prognostic potential of PXN in human cancer.

    Pan-cancer analysis reveals an immunological role and prognostic potential of PXN in human cancer.
    Chen Y, Zhao H, Xiao Y, Shen P, Tan L, Zhang S, Liu Q, Gao Z, Zhao J, Zhao Y, Guo Y, Feng Y., Free PMC Article

    07/24/2021
    Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome.

    Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome.
    Wang W, Hu D, Feng Y, Wu C, Song Y, Liu W, Li A, Wang Y, Chen K, Tian M, Xiao F, Zhang Q, Chen W, Pan P, Wan P, Liu Y, Lan H, Wu K, Wu J., Free PMC Article

    07/3/2021
    Paxillin knockdown suppresses metastasis and epithelialmesenchymal transition in colorectal cancer via the ERK signalling pathway.

    Paxillin knockdown suppresses metastasis and epithelial‑mesenchymal transition in colorectal cancer via the ERK signalling pathway.
    Wen L, Zhang X, Zhang J, Chen S, Ma Y, Hu J, Yue T, Wang J, Zhu J, Wu T, Wang X., Free PMC Article

    05/22/2021
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