| PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A Clinicopathologic, Prognostic, and Immunohistochemical Study. | PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A Clinicopathologic, Prognostic, and Immunohistochemical Study.
Harb OA, Elfeky MA, Alabiad MA, Hemeda R, Allam AS, El Hawary AT, Elbaz M, Sharaf AL, Gertallah LM, Abdelaziz AM, Shalaby AM, Alorini M, Yahia AIO, Negm M. | 02/22/2024 |
| LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis. | LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis.
Wang H, He D. | 12/20/2023 |
| Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress. | Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress.
Cui B, He B, Huang Y, Wang C, Luo H, Lu J, Su K, Zhang X, Luo Y, Zhao Z, Yang Y, Zhang Y, An F, Wang H, Lam EW, Kelley KW, Wang L, Liu Q, Peng F., Free PMC Article | 10/25/2023 |
| IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. | IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Zheng K, Sha N, Hou G, Leng Z, Zhao Q, Zhang L, He L, Xu M, Jiang Y, Chen T., Free PMC Article | 10/10/2023 |
| Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients. | Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients.
Xu X, Wang Y, Hu X, Zhu Y, Wang J, Guo J., Free PMC Article | 09/1/2023 |
| SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3. | SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3.
Li Z, Liu J, Fu H, Li Y, Liu Q, Song W, Zeng M., Free PMC Article | 10/29/2022 |
| The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer. | The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer.
Zhou B, Mai Z, Ye Y, Song Y, Zhang M, Yang X, Xia W, Qiu X. | 10/8/2022 |
| Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. | Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Kay EJ, Paterson K, Riera-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S., Free PMC Article | 07/2/2022 |
| Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma. | Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma.
Xu Y, Zuo W, Wang X, Zhang Q, Gan X, Tan N, Jia W, Liu J, Li Z, Zhou B, Zhao D, Xie Z, Tan Y, Zheng S, Liu C, Li H, Chen Z, Yang X, Huang Z., Free PMC Article | 03/26/2022 |
| Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions. | Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA., Free PMC Article | 02/26/2022 |
| MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1). | MicroRNA hsa-miR-150-5p inhibits nasopharyngeal carcinogenesis by suppressing PYCR1 (pyrroline-5-carboxylate reductase 1).
Li Z, Zhou X, Huang J, Xu Z, Xing C, Yang J, Zhou X., Free PMC Article | 02/19/2022 |
| PYCR1 promotes bladder cancer by affecting the Akt/Wnt/beta-catenin signaling. | PYCR1 promotes bladder cancer by affecting the Akt/Wnt/β-catenin signaling.
Du S, Sui Y, Ren W, Zhou J, Du C. | 02/12/2022 |
| MiR-1207-5p targets PYCR1 to inhibit the progression of prostate cancer. | MiR-1207-5p targets PYCR1 to inhibit the progression of prostate cancer.
Xu H, He Y, Lin L, Li M, Zhou Z, Yang Y. | 12/25/2021 |
| Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression. | Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Song W, Yang K, Luo J, Gao Z, Gao Y., Free PMC Article | 08/21/2021 |
| MiR-328-3p inhibits lung adenocarcinoma-genesis by downregulation PYCR1. | MiR-328-3p inhibits lung adenocarcinoma-genesis by downregulation PYCR1.
Lu J, Lin J, Zhou Y, Ye K, Fang C. | 06/26/2021 |
| Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis. | Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis.
Kuo CL, Chou HY, Chiu YC, Cheng AN, Fan CC, Chang YN, Chen CH, Jiang SS, Chen NJ, Lee AY. | 12/19/2020 |
| PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer. | PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer.
Zhuang J, Song Y, Ye Y, He S, Ma X, Zhang M, Ni J, Wang J, Xia W., Free PMC Article | 08/15/2020 |
| Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) K1 oncoprotein interacted with and activated PYCR enzyme, increasing intracellular proline concentration. Consequently, the K1-PYCR interaction promoted tumor cell growth in 3D spheroid culture and tumorigenesis in nude mice. This study demonstrates that an increase of proline biosynthesis induced by K1-PYCR interaction is critical for KSHV-mediated tumorigenesis. | Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.
Choi UY, Lee JJ, Park A, Zhu W, Lee HR, Choi YJ, Yoo JS, Yu C, Feng P, Gao SJ, Chen S, Eoh H, Jung JU., Free PMC Article | 07/25/2020 |
| PYCR1 plays a role in the proliferation, epithelial-mesenchymal transition and drug resistance by regulating STAT3-mediated p38 MAPK and NF-kappaB signalling pathways in the colorectal cancer cells.PYCR1 is highly espressed in tissues and cells of the colorectal cancer patients. | Knockdown of PYCR1 inhibits proliferation, drug resistance and EMT in colorectal cancer cells by regulating STAT3-Mediated p38 MAPK and NF-κB signalling pathway.
Yan K, Xu X, Wu T, Li J, Cao G, Li Y, Ji Z. | 07/25/2020 |
| High PYCR1 expression is associated with lung adenocarcinoma. | PYCR1 knockdown inhibits the proliferation, migration, and invasion by affecting JAK/STAT signaling pathway in lung adenocarcinoma.
Gao Y, Luo L, Xie Y, Zhao Y, Yao J, Liu X. | 07/11/2020 |
| High PYCR1 expression is associated with migration and Invasion of Nonsmall Cell Lung Cancer. | Pyrroline-5-Carboxylate Reductase 1 Accelerates the Migration and Invasion of Nonsmall Cell Lung Cancer In Vitro.
Sang S, Zhang C, Shan J. | 02/8/2020 |
| acetylation of PYCR1 at K228 inhibits cell proliferation, while deacetylation of PYCR1 mediated by SIRT3 increases PYCR1's activity. Our findings on the regulation of PYCR1 linked proline metabolism with SIRT3, CBP and cell growth, thus providing a potential approach for cancer therapy. | SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
Chen S, Yang X, Yu M, Wang Z, Liu B, Liu M, Liu L, Ren M, Qi H, Zou J, Vucenik I, Zhu WG, Luo J., Free PMC Article | 12/21/2019 |
| Authors describe a biosynthetic pathway exhibited by cells expressing mutant IDH1. By virtue of a change in cellular redox homeostasis, IDH1-mutated cells synthesize excess glutamine-derived proline through enhanced activity of pyrroline 5-carboxylate reductase 1 (PYCR1), coupled to NADH oxidation. | Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA., Free PMC Article | 09/21/2019 |
| PYCR1 is negatively regulated by miR-488 and then promotes the occurrence and development of non-small-cell lung cancer and activates p38 MAPK pathway. | PYCR1 promotes the progression of non-small-cell lung cancer under the negative regulation of miR-488.
Wang D, Wang L, Zhang Y, Yan Z, Liu L, Chen G. | 06/15/2019 |
| we firmly establish biallelic mutations in POLR3A as the genetic cause of a recognizable, neonatal, Wiedemann-Rautenstrauch-like progeroid syndrome. Thus, we suggest that POLR3A mutations are causal for a portion of under-diagnosed early-onset segmental progeroid syndromes | Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations.
Lessel D, Ozel AB, Campbell SE, Saadi A, Arlt MF, McSweeney KM, Plaiasu V, Szakszon K, Szőllős A, Rusu C, Rojas AJ, Lopez-Valdez J, Thiele H, Nürnberg P, Nickerson DA, Bamshad MJ, Li JZ, Kubisch C, Glover TW, Gordon LB., Free PMC Article | 12/22/2018 |