| Integration of risk variants from GWAS with SARS-CoV-2 RNA interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19. | Integration of risk variants from GWAS with SARS-CoV-2 RNA interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19.
Shi W, Chen M, Pan T, Chen M, Cheng Y, Hao Y, Chen S, Tang Y., Free PMC Article | 11/28/2023 |
| RAB2A promotes cervical cancer progression as revealed by comprehensive analysis of HPV integration and proteome in longitudinal cervical samples. | RAB2A promotes cervical cancer progression as revealed by comprehensive analysis of HPV integration and proteome in longitudinal cervical samples.
Meng Y, Lin S, Zhou Y, Yi X, Wu P, Zhang Q, Ge W, Cao C, Gao P, Zhi W, Peng T, Wei J, Ding W, Ma D, Li G, Yang Q, Guo T, Zeng X, Wu P., Free PMC Article | 04/9/2022 |
| RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. | RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.
Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, Chen S, Zhu Y, Mei M, Bao S, Liu W, Tang Z, Sun Q., Free PMC Article | 08/22/2020 |
| Bioinformatics were used to determine the target gene of miR192 and Rasrelated protein Rab2A (RAB2A) was identified as a downstream target of miR192. Following the determination of the role of the miR192RAB2A pathway in colon cancer, small molecules that may regulate miR192 were screened and the results demonstrated that simvastatin is an activator of miR192. | MicroRNA‑192 acts as a tumor suppressor in colon cancer and simvastatin activates miR‑192 to inhibit cancer cell growth.
Zheng XF, Liu KX, Wang XM, Zhang R, Li X. | 05/25/2019 |
| S100A7 affects cell motility and invasion by regulating the RAB2A-associated MAPK signaling cascades. | S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Dey KK, Bharti R, Dey G, Pal I, Rajesh Y, Chavan S, Das S, Das CK, Jena BC, Halder P, Ray JG, Kulavi I, Mandal M. | 01/13/2018 |
| Identify Rab2 as a key factor for autophagic and endocytic cargo delivery to and degradation in lysosomes. | Rab2 promotes autophagic and endocytic lysosomal degradation.
Lőrincz P, Tóth S, Benkő P, Lakatos Z, Boda A, Glatz G, Zobel M, Bisi S, Hegedűs K, Takáts S, Scita G, Juhász G., Free PMC Article | 09/16/2017 |
| our data reveal that RAB2A is new critical membrane trafficking players in the regulation of mesenchymal properties of normal and tumorigenic cells and a critical determinant of an invasive, proteolytic mode of BC progression. | RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.
Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G., Free PMC Article | 08/19/2017 |
| RAB2A variance has effect on the structure and function of the PFC and related cognitive functions. | RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory.
Li J, Liu B, Chen C, Cui Y, Shang L, Zhang Y, Wang C, Zhang X, He Q, Zhang W, Bi W, Jiang T., Free PMC Article | 08/13/2016 |
| This study demonstrated that RAB2A mutation showing the highest statistical significance in Autism and Schizophrenia. | De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia.
Takata A, Ionita-Laza I, Gogos JA, Xu B, Karayiorgou M., Free PMC Article | 07/16/2016 |
| The immunohistochemistry-based validation using tissue microarray slides in oral squamous cell carcinoma revealed overexpression of the RAB2A and PRDX1 gene in 80 and 68 % of the tested clinical cases, respectively. | Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach.
Dey KK, Pal I, Bharti R, Dey G, Kumar BN, Rajput S, Parekh A, Parida S, Halder P, Kulavi I, Mandal M. | 04/30/2016 |
| Pin1/Rab2A/Erk drives BCSC expansion and tumorigenicity, suggesting potential drug targets. | The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP., Free PMC Article | 01/16/2016 |
| As a result of the translocations, RAB2A-PLAG1, the constitutively active promoter of the partner gene drives the ectopic expression of PLAG1. | Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma.
Yoshida H, Miyachi M, Ouchi K, Kuwahara Y, Tsuchiya K, Iehara T, Konishi E, Yanagisawa A, Hosoi H. | 12/6/2014 |
| first X-ray crystal structure of RicA to 2.7 A resolution and have quantified the affinity of RicA binding to human Rab2 in its GDP-bound and nucleotide-free forms | Molecular structure of the Brucella abortus metalloprotein RicA, a Rab2-binding virulence effector.
Herrou J, Crosson S., Free PMC Article | 03/8/2014 |
| The authors identified a specific interaction between the human small GTPase Rab2 and a Brucella spp. protein named RicA. | Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.
de Barsy M, Jamet A, Filopon D, Nicolas C, Laloux G, Rual JF, Muller A, Twizere JC, Nkengfac B, Vandenhaute J, Hill DE, Salcedo SP, Gorvel JP, Letesson JJ, De Bolle X. | 10/1/2011 |
| The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders. | Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Kim S, Webster MJ, Kim S, Webster MJ. | 07/23/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Kim S, Webster MJ, Kim S, Webster MJ. | 04/7/2010 |
| ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins | ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. | 01/21/2010 |
| These data demonstrate that Rab2 and Rab6 differentially influence anterograde transport and signaling of GPCRs. | Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases.
Dong C, Wu G., Free PMC Article | 01/21/2010 |
| Rab2 interacts directly with atypical protein kinase C iota/lambda and inhibits aPKCiota/lambda-dependent GADPH phosphorylation | Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation.
Tisdale EJ. | 01/21/2010 |