| RAB6A functions as a critical modulator of the stem-like subsets in cholangiocarcinoma. | RAB6A functions as a critical modulator of the stem-like subsets in cholangiocarcinoma.
Yang L, Zhu Z, Zheng Y, Yang J, Liu Y, Shen T, Li M, He H, Huang H, Dai W. | 09/23/2023 |
| Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. | Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.
Yang L, Liu G, Li X, Xia Z, Wang Y, Lin W, Zhang W, Zhang W, Li X., Free PMC Article | 05/15/2021 |
| Rab6 regulates recycling and retrograde trafficking of MR1 molecules. | Rab6 regulates recycling and retrograde trafficking of MR1 molecules.
Huber ME, Kurapova R, Heisler CM, Karamooz E, Tafesse FG, Harriff MJ., Free PMC Article | 03/28/2021 |
| We observed that, irrespective of the transported cargos, most post-Golgi carriers are positive for RAB6 and that its inactivation leads to a broad reduction of protein secretion. RAB6 may thus be a general regulator of post-Golgi secretion. | RAB6 and microtubules restrict protein secretion to focal adhesions.
Fourriere L, Kasri A, Gareil N, Bardin S, Bousquet H, Pereira D, Perez F, Goud B, Boncompain G, Miserey-Lenkei S., Free PMC Article | 05/16/2020 |
| it was suggested that ARHGEF10 is involved in the regulation of Rab6A and Rab8A localization and invasion of breast carcinoma cells, in which Rab8 also acts via regulation of membrane trafficking. | Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.
Shibata S, Teshima Y, Niimi K, Inagaki S., Free PMC Article | 04/11/2020 |
| LAT, once internalized, transits through the Golgi-trans-Golgi network (TGN), where it is repolarized to the immune synapse. | Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
Carpier JM, Zucchetti AE, Bataille L, Dogniaux S, Shafaq-Zadah M, Bardin S, Lucchino M, Maurin M, Joannas LD, Magalhaes JG, Johannes L, Galli T, Goud B, Hivroz C., Free PMC Article | 06/22/2019 |
| These results suggest that miR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6. | MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.
Yang L, Lin Z, Wang Y, Gao S, Li Q, Li C, Xu W, Chen J, Liu T, Song Z, Liu G. | 01/5/2019 |
| Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. | ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.
Shibata S, Kawanai T, Hara T, Yamamoto A, Chaya T, Tokuhara Y, Tsuji C, Sakai M, Tachibana T, Inagaki S. | 08/5/2017 |
| Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions. | Rab6 regulation of the kinesin family KIF1C motor domain contributes to Golgi tethering.
Lee PL, Ohlson MB, Pfeffer SR., Free PMC Article | 12/26/2015 |
| GORAB missense mutation disrupt RAB6 protein binding in genetic skin diseases. | GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting.
Egerer J, Emmerich D, Fischer-Zirnsak B, Chan WL, Meierhofer D, Tuysuz B, Marschner K, Sauer S, Barr FA, Mundlos S, Kornak U. | 12/19/2015 |
| several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells | Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.
Matsuto M, Kano F, Murata M. | 12/5/2015 |
| Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6. | miR-5100 promotes tumor growth in lung cancer by targeting Rab6.
Huang H, Jiang Y, Wang Y, Chen T, Yang L, He H, Lin Z, Liu T, Yang T, Kamp DW, Wu B, Liu G. | 06/20/2015 |
| Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. | Identification and characterization of multiple novel Rab-myosin Va interactions.
Lindsay AJ, Jollivet F, Horgan CP, Khan AR, Raposo G, McCaffrey MW, Goud B., Free PMC Article | 07/5/2014 |
| Mint1 826 bridges APP to the small GTPase | A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.
Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, Waschbüsch D, Eggert S, Formstecher E, Müthing J, Dreisewerd K, Kins S, Goud B, Barnekow A., Free PMC Article | 01/11/2014 |
| The presence of an active pool of Rab6 within host cells early during infection is required to support efficient intracellular growth of L. pneumophila. | Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA.
Chen Y, Machner MP., Free PMC Article | 08/10/2013 |
| Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. | Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.
Pusapati GV, Luchetti G, Pfeffer SR., Free PMC Article | 02/16/2013 |
| GTP-bound form of Rab6 promotes retrograde trafficking of cav-2 from the Golgi to ER | Rab6-mediated retrograde transport regulates inner nuclear membrane targeting of caveolin-2 in response to insulin.
Jeong K, Kwon H, Lee J, Jang D, Hwang EM, Park JY, Pak Y. | 12/8/2012 |
| the crystal structure of the human Rab6A'(Q72L) mutant form at 1.9A resolution is reported. | Crystal structure of Rab6A'(Q72L) mutant reveals unexpected GDP/Mg²⁺ binding with opened GTP-binding domain.
Shin YC, Yoon JH, Jang TH, Kim SY, Heo WD, So I, Jeon JH, Park HH. | 11/17/2012 |
| Rab6 modulates the unfolded protein response (UPR), increased levels inhibit whereas decreased levels augment UPR induction. | Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease.
Elfrink HL, Zwart R, Cavanillas ML, Schindler AJ, Baas F, Scheper W. | 09/22/2012 |
| Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number | Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.
Storrie B, Micaroni M, Morgan GP, Jones N, Kamykowski JA, Wilkins N, Pan TH, Marsh BJ., Free PMC Article | 08/18/2012 |
| Rab6 is required for Rab8A association with exocytotic vesicles. | Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.
Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A. | 10/15/2011 |
| In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days | Crystallization of an engineered RUN domain of Rab6-interacting protein 1/DENND5.
Fernandes H, Franklin E, Khan AR., Free PMC Article | 09/3/2011 |
| The authors found that the small GTPase Rab6 also interacts indirectly with cytomegalovirus pp150 through its interaction with Bicaudal D1. | A role for the small GTPase Rab6 in assembly of human cytomegalovirus.
Indran SV, Britt WJ., Free PMC Article | 06/25/2011 |
| Data show that Rab6, a Golgi-associated Rab, forms a complex with myosin II, contributes to its localization at the Golgi complex and, unexpectedly, controls the fission of Rab6 vesicles. | Rab and actomyosin-dependent fission of transport vesicles at the Golgi complex.
Miserey-Lenkei S, Chalancon G, Bardin S, Formstecher E, Goud B, Echard A. | 07/26/2010 |
| Data show that iPLA(1)gamma is a novel membrane transport factor that contributes to a specific Golgi-to-ER retrograde pathway distinct from presently characterized COPI- and Rab6-dependent pathways. | Intracellular phospholipase A1gamma (iPLA1gamma) is a novel factor involved in coat protein complex I- and Rab6-independent retrograde transport between the endoplasmic reticulum and the Golgi complex.
Morikawa RK, Aoki J, Kano F, Murata M, Yamamoto A, Tsujimoto M, Arai H., Free PMC Article | 01/21/2010 |