| RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment. | RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.
Chen Y, Wen J, Li Q, Peng D, Liao C, Ma X, Wang M, Niu J, Wang D, Li Y, Zhang X, Zhou H, Zou J, Li L, Liu L. | 02/13/2024 |
| Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis. | Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis.
Shan J, Chang LY, Li DJ, Wang XQ. | 08/31/2023 |
| RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. | RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Ren JG, Xing B, Lv K, O'Keefe RA, Wu M, Wang R, Bauer KM, Ghazaryan A, Burslem GM, Zhang J, O'Connell RM, Pillai V, Hexner EO, Philips MR, Tong W., Free PMC Article | 08/28/2023 |
| RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion. | RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.
Meneses KM, Pandya P, Lindemann JA, Al-Qasrawi DS, Argo RA, Weems CM, Beetler DJ, Vijay GV, Yan IK, Wolfram J, Patel T, Justilien V., Free PMC Article | 08/10/2023 |
| Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer. | Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer.
Nambara S, Masuda T, Hirose K, Hu Q, Tobo T, Ozato Y, Kurashige J, Hiraki Y, Hisamatsu Y, Iguchi T, Sugimachi K, Oki E, Yoshizumi T, Mimori K., Free PMC Article | 01/11/2023 |
| RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer. | RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer.
An HJ, Lee JS, Yang JW, Kim MH, Na JM, Song DH., Free PMC Article | 09/3/2022 |
| NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression. | NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
Joshi CS, Mora A, Felder PA, Mysorekar IU. | 02/19/2022 |
| Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication. | Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.
Dai Y, Ai B, Liu Y, Pascal LE, Wang Z, Dhir R, Sun X, Jiang Y., Free PMC Article | 09/4/2021 |
| Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo. | Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo.
Cheng A, Choi D, Lora M, Shum-Tim D, Rak J, Colmegna I., Free PMC Article | 08/7/2021 |
| Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux. | Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
Li R, Dong C, Jiang K, Sun R, Zhou Y, Yin Z, Lv J, Zhang J, Wang Q, Wang L. | 05/29/2021 |
| Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth. | Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth.
Ku KE, Choi N, Sung JH., Free PMC Article | 02/20/2021 |
| The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein. | The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein.
Underwood R, Wang B, Carico C, Whitaker RH, Placzek WJ, Yacoubian TA., Free PMC Article | 01/2/2021 |
| A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules. | A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.
Bhurke A, Kannan A, Neff A, Ma Q, Laws MJ, Taylor RN, Bagchi MK, Bagchi IC., Free PMC Article | 08/29/2020 |
| oncogenic effects through exosome independent function in renal cell carcinoma including sunitinib-resistant | Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.
Tsuruda M, Yoshino H, Okamura S, Kuroshima K, Osako Y, Sakaguchi T, Sugita S, Tatarano S, Nakagawa M, Enokida H., Free PMC Article | 08/1/2020 |
| High Rab27B expression could be an unfavorable prognostic factor in patients with squamous cell carcinoma of the lung | Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Koh HM, Song DH., Free PMC Article | 02/8/2020 |
| Data show that member RAS oncogene family protein RAB27B (RAB27B) expression is required for the secretion of colorectal cancer stem cells (CRCSCs) exosomes, and exosomal miR-146a promotes stem-like properties and tumorigenicity by targeting endocytic adaptor protein Numb (Numb) in colorectal cancer (CRC) cells. | RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.
Cheng WC, Liao TT, Lin CC, Yuan LE, Lan HY, Lin HH, Teng HW, Chang HC, Lin CH, Yang CY, Huang SC, Jiang JK, Yang SH, Yang MH, Hwang WL. | 02/8/2020 |
| Results indicate that Rab27b is highly expressed in lung adenocarcinoma (LUAD) and correlates with malignant attributes of LUAD suggesting that Rab27b may be identified as a potential indicator of metastasis and prognosis for LUAD. | Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Zhang L, Fan W, Xu L, Mao Q, Chen Y, Mao Y, Xu L, Wang J., Free PMC Article | 04/27/2019 |
| Findings indicate that rab GTP-binding proteins Rab27A and Rab27B play significant roles in cell invasion, proliferation, and apoptosis, as well as in chemotherapy resistance. | Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells.
Li J, Jin Q, Huang F, Tang Z, Huang J. | 05/26/2018 |
| RAB27A, RAB27B and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B and VPS36, with RAB27A and RAB27B being dependent on VPS36. | RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
Worst TS, Meyer Y, Gottschalt M, Weis CA, von Hardenberg J, Frank C, Steidler A, Michel MS, Erben P. | 06/24/2017 |
| decreased expression of Rab27A and Rab27B, especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients. | Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer.
Dong W, Cui J, Yang J, Li W, Wang S, Wang X, Li X, Lu Y, Xiao W. | 10/22/2016 |
| Data indicate that a significant correlation between rab GTP-binding protein (RAB27B) and p53 tumor suppressor protein (p53) expression was observed. | Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Zhao H, Wang Q, Wang X, Zhu H, Zhang S, Wang W, Wang Z, Huang J., Free PMC Article | 10/22/2016 |
| MiR-193a-3p and miR-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma | MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively.
Pu Y, Zhao F, Cai W, Meng X, Li Y, Cai S., Free PMC Article | 08/6/2016 |
| These data indicate that Rab27B is involved at a different steps of zymogen granule maturation and secretion, which is distinct from that of Rab3D. | Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion.
Hou Y, Ernst SA, Lentz SI, Williams JA., Free PMC Article | 08/6/2016 |
| Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression. | Rab27 GTPases distribute extracellular nanomaps for invasive growth and metastasis: implications for prognosis and treatment.
Hendrix A, De Wever O., Free PMC Article | 05/28/2016 |
| Decreased invasion partly resulted from reduced expression and activation of MMP-9 after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo. | Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion.
Wang H, Wang Y, Bao Z, Zhang C, Liu Y, Cai J, Jiang C. | 05/14/2016 |