| Establishment of a prognostic model to predict chemotherapy response and identification of RAC3 as a chemotherapeutic target in bladder cancer. | Establishment of a prognostic model to predict chemotherapy response and identification of RAC3 as a chemotherapeutic target in bladder cancer.
Chen Y, Huang M, Lu J, Zhang Q, Wu J, Peng S, Chen S, Zhang Y, Cheng L, Lin T, Chen X, Huang J. | 01/15/2024 |
| Gain-of-function p.F28S variant in RAC3 disrupts neuronal differentiation, migration and axonogenesis during cortical development, leading to neurodevelopmental disorder. | Gain-of-function p.F28S variant in RAC3 disrupts neuronal differentiation, migration and axonogenesis during cortical development, leading to neurodevelopmental disorder.
Nishikawa M, Scala M, Umair M, Ito H, Waqas A, Striano P, Zara F, Costain G, Capra V, Nagata KI. | 02/27/2023 |
| Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes. | Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes.
Scala M, Nishikawa M, Ito H, Tabata H, Khan T, Accogli A, Davids L, Ruiz A, Chiurazzi P, Cericola G, Schulte B, Monaghan KG, Begtrup A, Torella A, Pinelli M, Denommé-Pichon AS, Vitobello A, Racine C, Mancardi MM, Kiss C, Guerin A, Wu W, Gabau Vila E, Mak BC, Martinez-Agosto JA, Gorin MB, Duz B, Bayram Y, Carvalho CMB, Vengoechea JE, Chitayat D, Tan TY, Callewaert B, Kruse B, Bird LM, Faivre L, Zollino M, Biskup S, Undiagnosed Diseases Network, Telethon Undiagnosed Diseases Program, Striano P, Nigro V, Severino M, Capra V, Costain G, Nagata KI., Free PMC Article | 10/1/2022 |
| Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer. | Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer.
Meijuan C, Fang L, Min F, Qian W. | 09/10/2022 |
| Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies. | Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies.
Scala M, Nishikawa M, Nagata KI, Striano P., Free PMC Article | 01/22/2022 |
| Rac3 Expression and its Clinicopathological Significance in Patients With Bladder Cancer. | Rac3 Expression and its Clinicopathological Significance in Patients With Bladder Cancer.
Chen M, Nie Z, Cao H, Gao Y, Wen X, Zhang C, Zhang S., Free PMC Article | 01/8/2022 |
| Rac Family Small GTPase 3 Correlates with Progression and Poor Prognosis in Bladder Cancer. | Rac Family Small GTPase 3 Correlates with Progression and Poor Prognosis in Bladder Cancer.
Zheng W, Zhang J, Song Q, Xu Y, Zhu M, Ma J. | 03/20/2021 |
| Our study supports that RAC3 variants cause syndromic neurodevelopmental disorders and brain structural abnormality, and expands the phenotypic spectrum of RAC3-related disorders. | A de novo variant in RAC3 causes severe global developmental delay and a middle interhemispheric variant of holoprosencephaly.
Hiraide T, Kaba Yasui H, Kato M, Nakashima M, Saitsu H. | 02/8/2020 |
| Missense variants in RAC3 cause a novel brain disorder, likely through a mechanism of constitutive protein activation | De novo missense variants in RAC3 cause a novel neurodevelopmental syndrome.
Costain G, Callewaert B, Gabriel H, Tan TY, Walker S, Christodoulou J, Lazar T, Menten B, Orkin J, Sadedin S, Snell M, Vanlander A, Vergult S, White SM, Scherer SW, Hayeems RZ, Blaser S, Wodak SJ, Chitayat D, Marshall CR, Meyn MS. | 06/22/2019 |
| Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. | Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
Donnelly SK, Cabrera R, Mao SPH, Christin JR, Wu B, Guo W, Bravo-Cordero JJ, Condeelis JS, Segall JE, Hodgson L., Free PMC Article | 12/9/2017 |
| Rac3 regulates the biological behaviors of lung adenocarcinoma through a mechanism of downregulating CCND1, MYC, and TFDP1 of cell cycle pathway. | Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma.
Wang G, Wang H, Zhang C, Liu T, Li Q, Lin X, Xie J, Liu H. | 02/18/2017 |
| Efficient silencing of Rac3 strongly inhibited A549 cell proliferation. | Silencing of Rac3 inhibits proliferation and induces apoptosis of human lung cancer cells.
Liu TQ, Wang GB, Li ZJ, Tong XD, Liu HX. | 12/26/2015 |
| Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 by regulating its stability and regulates the TGFbeta1-induced E-cadherin down-regulation. | F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation.
Dong S, Zhao J, Wei J, Bowser RK, Khoo A, Liu Z, Luketich JD, Pennathur A, Ma H, Zhao Y., Free PMC Article | 12/20/2014 |
| Report role of Rac3 in breast cancer aggressiveness and show the potential usefulness of Rac3 depletion in breast cancer therapy. | Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines.
Gest C, Joimel U, Huang L, Pritchard LL, Petit A, Dulong C, Buquet C, Hu CQ, Mirshahi P, Laurent M, Fauvel-Lafève F, Cazin L, Vannier JP, Lu H, Soria J, Li H, Varin R, Soria C., Free PMC Article | 06/15/2013 |
| Rac1b forms a complex with NADPH oxidase and promotes the production of reactive oxygen species, expression of Snail, and activation of the epithelial-mesenchymal transition program. | Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition.
Lee K, Chen QK, Lui C, Cichon MA, Radisky DC, Nelson CM., Free PMC Article | 03/16/2013 |
| Activation of epithelial-mesenchymal transition by MMP-induced expression of Rac1b gave rise to lung adenocarcinoma. | Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.
Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC., Free PMC Article | 02/2/2013 |
| Rac3 GTPase has a role in the regulation of autophagy | A role for Rac3 GTPase in the regulation of autophagy.
Zhu WL, Hossain MS, Guo DY, Liu S, Tong H, Khakpoor A, Casey PJ, Wang M., Free PMC Article | 12/10/2011 |
| RAC3 is a novel ERalpha co-activator that promotes cell migration and has prognostic value for ERalpha-positive breast cancer metastasis. | RAC3 is a pro-migratory co-activator of ERα.
Walker MP, Zhang M, Le TP, Wu P, Lainé M, Greene GL., Free PMC Article | 06/25/2011 |
| Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling. | Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling.
Hajdo-Milasinovic A, van der Kammen RA, Moneva Z, Collard JG. | 01/21/2010 |
| Data demonstrate that Rac3 shares with Rac1 the ability to interfere with cadherin-mediated adhesion. | PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.
Lozano E, Frasa MA, Smolarczyk K, Knaus UG, Braga VM. | 01/21/2010 |
| results suggest a role for both the Rac1 and Rac3 GTPases in human breast cancer progression | Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.
Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF., Free PMC Article | 01/21/2010 |
| functional analysis of Rac1 and Rac3 using RNA interference reveals a critical role for these GTPases in the invasive behavior of glioma and breast carcinoma cells | Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion.
Chan AY, Coniglio SJ, Chuang YY, Michaelson D, Knaus UG, Philips MR, Symons M. | 01/21/2010 |
| Our data is the first report of the frequency of Rac3 overexpression and mutation in human brain tumors. Overexpression may be associated with aggressive tumor behavior | Expression of Rac3 in human brain tumors.
Hwang SL, Chang JH, Cheng TS, Sy WD, Lieu AS, Lin CL, Lee KS, Howng SL, Hong YR. | 01/21/2010 |
| RAC1 and RAC3 have opposing functions in cell adhesion and differentiation in neuronal cells. | Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells.
Hajdo-Milasinović A, Ellenbroek SI, van Es S, van der Vaart B, Collard JG. | 01/21/2010 |