| RAF1 gene fusions are recurrent driver events in infantile fibrosarcoma-like mesenchymal tumors. | RAF1 gene fusions are recurrent driver events in infantile fibrosarcoma-like mesenchymal tumors.
Motta M, Barresi S, Pizzi S, Bifano D, Lopez Marti J, Garrido-Pontnou M, Flex E, Bruselles A, Giovannoni I, Rotundo G, Fragale A, Tirelli V, Vallese S, Ciolfi A, Bisogno G, Alaggio R, Tartaglia M. | 06/5/2024 |
| Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer's Disease. | Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer's Disease.
Hong H, Yu L, Cong W, Kang K, Gao Y, Guan Q, Meng X, Zhang H, Zhou Z. | 05/7/2024 |
| Molecular analyses of the C-terminal CRAF variants associated with cardiomyopathy reveal their opposing impacts on the active conformation of the kinase domain. | Molecular analyses of the C-terminal CRAF variants associated with cardiomyopathy reveal their opposing impacts on the active conformation of the kinase domain.
Nakhaei-Rad S, Janatifard F, Dvorsky R, Ahmadian MR, Housaindokht MR. | 04/19/2024 |
| RAF1 mutation leading to hypertrophic cardiomyopathy in a Chinese family with a history of sudden cardiac death: A diagnostic insight into Noonan syndrome. | RAF1 mutation leading to hypertrophic cardiomyopathy in a Chinese family with a history of sudden cardiac death: A diagnostic insight into Noonan syndrome.
Zheng J, Peng L, Cheng R, Li Z, Xie J, Huang E, Cheng J, Zhao Q., Free PMC Article | 02/7/2024 |
| PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. | PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis.
Kirkbride JA, Nilsson GY, Kim JI, Takeya K, Tanaka Y, Tokumitsu H, Suizu F, Eto M., Free PMC Article | 01/3/2024 |
| Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas. | Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.
Benhamida JK, Harmsen HJ, Ma D, William CM, Li BK, Villafania L, Sukhadia P, Mullaney KA, Dewan MC, Vakiani E, Karajannis MA, Snuderl M, Zagzag D, Ladanyi M, Rosenblum MK, Bale TA., Free PMC Article | 08/31/2023 |
| TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1. | TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.
Fei X, Dou YN, Sun K, Wei J, Guo Q, Wang L, Wu X, Lv W, Jiang X, Fei Z., Free PMC Article | 07/19/2023 |
| Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues. | Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues.
Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger M, Kutschka I, Cyganek L, Zenker M, Kensah G, Ahmadian MR., Free PMC Article | 06/23/2023 |
| SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus. | SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.
Geng W, Cao M, Dong K, An J, Gao H., Free PMC Article | 06/2/2023 |
| RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status. | RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.
Dorard C, Madry C, Buhard O, Toifl S, Didusch S, Ratovomanana T, Letourneur Q, Dolznig H, Garnett MJ, Duval A, Baccarini M., Free PMC Article | 05/30/2023 |
| RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis. | RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis.
Wong S, Tan YX, Loh AYT, Tan KY, Lee H, Aziz Z, Nelson SF, Özkan E, Kayserili H, Escande-Beillard N, Reversade B., Free PMC Article | 05/15/2023 |
| Cardiac features of Noonan syndrome in Japanese patients. | Cardiac features of Noonan syndrome in Japanese patients.
Ichikawa Y, Kuroda H, Ikegawa T, Kawai S, Ono S, Kim KS, Yanagi S, Kurosawa K, Aoki Y, Ueda H. | 05/10/2023 |
| The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade. | The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade.
Qian Y, Zhou L, Luk STY, Xu J, Li W, Gou H, Chen H, Kang W, Yu J, Wong CC., Free PMC Article | 02/27/2023 |
| HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. | HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
Yuan J, Lv T, Yang J, Wu Z, Yan L, Yang J, Shi Y, Jiang L., Free PMC Article | 01/28/2023 |
| MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1, IRS2, and RAF1 Genes in Gestational Diabetes Mellitus. | MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1, IRS2, and RAF1 Genes in Gestational Diabetes Mellitus.
Bhushan R, Rani A, Gupta D, Ali A, Dubey PK. | 08/27/2022 |
| Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1. | Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1.
Uludağ Alkaya D, Lissewski C, Yeşil G, Zenker M, Tüysüz B. | 03/5/2022 |
| The GPCR-beta-arrestin complex allosterically activates C-Raf by binding its amino terminus. | The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino terminus.
Zang Y, Kahsai AW, Pakharukova N, Huang LY, Lefkowitz RJ., Free PMC Article | 02/19/2022 |
| miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway. | miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway.
Gheidari F, Arefian E, Adegani FJ, Kalhori MR, Seyedjafari E, Kabiri M, Teimoori-Toolabi L, Soleimani M. | 12/18/2021 |
| Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naive and primed pluripotent stem cells. | Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.
Wang X, Wang X, Zhang X, Zhang Y, Zhu Z, Li Y, Zhang M, Ji J, Yu Y, Ye SD., Free PMC Article | 12/18/2021 |
| Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence. | Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence.
Muniz L, Lazorthes S, Delmas M, Ouvrard J, Aguirrebengoa M, Trouche D, Nicolas E., Free PMC Article | 12/4/2021 |
| A structural model of a Ras-Raf signalosome. | A structural model of a Ras-Raf signalosome.
Mysore VP, Zhou ZW, Ambrogio C, Li L, Kapp JN, Lu C, Wang Q, Tucker MR, Okoro JJ, Nagy-Davidescu G, Bai X, Plückthun A, Jänne PA, Westover KD, Shan Y, Shaw DE., Free PMC Article | 11/27/2021 |
| RAF1 kinase activity is dispensable for KRAS/p53 mutant lung tumor progression. | RAF1 kinase activity is dispensable for KRAS/p53 mutant lung tumor progression.
Sanclemente M, Nieto P, Garcia-Alonso S, Fernández-García F, Esteban-Burgos L, Guerra C, Drosten M, Caleiras E, Martinez-Torrecuadrada J, Santamaría D, Musteanu M, Barbacid M. | 10/2/2021 |
| Crystal Structure Reveals the Full Ras-Raf Interface and Advances Mechanistic Understanding of Raf Activation. | Crystal Structure Reveals the Full Ras-Raf Interface and Advances Mechanistic Understanding of Raf Activation.
Cookis T, Mattos C., Free PMC Article | 09/25/2021 |
| RAF1 rearrangements are common in pancreatic acinar cell carcinomas. | RAF1 rearrangements are common in pancreatic acinar cell carcinomas.
Prall OWJ, Nastevski V, Xu H, McEvoy CRE, Vissers JHA, Byrne DJ, Takano E, Yerneni S, Ellis S, Green T, Mitchell CA, Murray WK, Scott CL, Grimmond SM, Hofmann O, Papenfuss A, Kee D, Fellowes A, Brown IS, Miller G, Kumarasinghe MP, Perren A, Nahm CB, Mittal A, Samra J, Ahadi M, Fox SB, Chou A, Gill AJ. | 07/24/2021 |
| Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles. | Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles.
Williams EA, Shah N, Montesion M, Sharaf R, Pavlick DC, Sokol ES, Alexander BM, Venstrom JM, Elvin JA, Ross JS, Tse JY, Mochel MC., Free PMC Article | 07/10/2021 |