| Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia. | Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia.
Pardo LM, Aanicai R, Zonic E, Hakonen AH, Zielske S, Bauer P, Bertoli-Avella AM. | 01/11/2024 |
| ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells. | ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
Zhang B, Ding J, Ma Z., Free PMC Article | 08/3/2023 |
| Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells. | Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.
Zhang H, Tao Y, Ding X, Wang Y, Wang X., Free PMC Article | 05/13/2023 |
| SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP. | SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.
Chen S, Li QH, Chen X, Bao HJ, Wu W, Shen F, Lu BF, Jiang RQ, Zong ZH, Zhao Y., Free PMC Article | 10/22/2022 |
| LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p. | LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p.
Wang L, Song X, Yu L, Liu B, Ma J, Yang W., Free PMC Article | 04/16/2022 |
| De novo missense variants in the RAP1B gene identified in two patients with syndromic thrombocytopenia. | De novo missense variants in the RAP1B gene identified in two patients with syndromic thrombocytopenia.
Niemann JH, Du C, Morlot S, Schmidt G, Auber B, Kaune B, Göhring G, Ripperger T, Schlegelberger B, Hofmann W, Smol T, Ait-Yahya E, Raimbault A, Lambilliotte A, Petit F, Steinemann D. | 07/3/2021 |
| MiR-181a Reduces Platelet Activation via the Inhibition of Endogenous RAP1B. | MiR-181a Reduces Platelet Activation via the Inhibition of Endogenous RAP1B.
Dahiya N, Atreya CD., Free PMC Article | 05/29/2021 |
| Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis. | Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis.
Perdomo L, Vidal-Gómez X, Soleti R, Vergori L, Duluc L, Chwastyniak M, Bisserier M, Le Lay S, Villard A, Simard G, Meilhac O, Lezoualc'h F, Khantalin I, Veerapen R, Dubois S, Boursier J, Henni S, Gagnadoux F, Pinet F, Andriantsitohaina R, Martínez MC, Metabol study Group., Free PMC Article | 05/29/2021 |
| MicroRNA-149 inhibits the progression of lung adenocarcinoma through targeting RAP1B and inactivating Wnt/beta-catenin pathway. | MicroRNA-149 inhibits the progression of lung adenocarcinoma through targeting RAP1B and inactivating Wnt/β-catenin pathway.
Jiang WS, Huang CL, Zhang J, Xu F, Dai XH. | 04/3/2021 |
| Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B. | Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B.
Xu JH, Zhao WY, Fang QQ, Wang XF, Zhang DD, Hu YY, Zheng B, Tan WQ. | 01/16/2021 |
| MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b. | MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b.
Fan M, Ma X, Wang F, Zhou Z, Zhang J, Zhou D, Hong Y, Wang Y, Wang G, Dong Q. | 01/2/2021 |
| miR-200b/c-RAP1B axis represses tumorigenesis and malignant progression of papillary thyroid carcinoma through inhibiting the NF-kappaB/Twist1 pathway. | miR-200b/c-RAP1B axis represses tumorigenesis and malignant progression of papillary thyroid carcinoma through inhibiting the NF-κB/Twist1 pathway.
Zhou B, Xu J, Chen Y, Gao S, Feng X, Lu X. | 10/31/2020 |
| miR-206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B. | miR-206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B.
Wang P, Gu J, Wang K, Shang J, Wang W. | 09/12/2020 |
| When amino acids are limited, the Rap1-GTPases confine lysosomes to the perinuclear region and reduce lysosome abundance, which suppresses mTORC1 signaling. | Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
Mutvei AP, Nagiec MJ, Hamann JC, Kim SG, Vincent CT, Blenis J., Free PMC Article | 08/1/2020 |
| The authors demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.
Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J., Free PMC Article | 05/16/2020 |
| Rap1b increased Twist 1 expression by targeting its promoter activity to induce proliferation and migration of hepatocellular carcinoma cells. | Rap1b enhances the invasion and migration of hepatocellular carcinoma cells by up-regulating Twist 1.
Tang Z, Peng H, Chen J, Liu Y, Yan S, Yu G, Chen Q, Tang H, Liu S. | 04/27/2019 |
| findings indicate that CAP1 is a geranylgeranyl-binding partner of Rap1 | Cyclase-associated protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase.
Zhang X, Cao S, Barila G, Edreira MM, Hong K, Wankhede M, Naim N, Buck M, Altschuler DL., Free PMC Article | 01/12/2019 |
| Talin-F0 domain binds to Rap1b like canonical Rap1 effectors despite little sequence homology, and disruption of the binding strongly impairs integrin activation, cell adhesion, and cell spreading. | Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation.
Zhu L, Yang J, Bromberger T, Holly A, Lu F, Liu H, Sun K, Klapproth S, Hirbawi J, Byzova TV, Plow EF, Moser M, Qin J., Free PMC Article | 09/22/2018 |
| Aberrant expression of lncRNA AFAP1-AS, a competing endogenous RNA of miR-181a, may involve in the onset and progression of Hirschsprung disease by augmenting the miR-181a target gene, RAP1B. | LncRNA AFAP1-AS Functions as a Competing Endogenous RNA to Regulate RAP1B Expression by sponging miR-181a in the HSCR.
Chen G, Peng L, Zhu Z, Du C, Shen Z, Zang R, Su Y, Xia Y, Tang W., Free PMC Article | 05/26/2018 |
| In RCC tissues and renal carcinoma cells, miR-28-5p is expressed at a low level and RAP1B is expressed at a high level. miR-28-5p inhibits the tumorigenesis of RCC by directly downregulating RAP1B and influencing the activation of two MAP kinases in the MAPK signaling pathway, p38 and Erk1/2. | miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.
Wang C, Wu C, Yang Q, Ding M, Zhong J, Zhang CY, Ge J, Wang J, Zhang C., Free PMC Article | 03/10/2018 |
| describe the methods for expression and purification of the plexin cytoplasmic region in E. coli, and characterization of its GAP activity using a photometric assay. We also provide a protocol for measuring GAP activity of single-chain constructs with Rap covalently linked to the plexin cytoplasmic region | In Vitro Assay for the Rap GTPase-Activating Protein Activity of the Purified Cytoplasmic Domain of Plexin.
Pascoe HG, Wang Y, Zhang X. | 02/17/2018 |
| Unlike Rap1B, phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS-607. | Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B.
Wilson JM, Prokop JW, Lorimer E, Ntantie E, Williams CL., Free PMC Article | 07/1/2017 |
| Data show that RAP1B expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B interacted with DVL2 and activated Wnt/beta-catenin signaling. | RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
Jia Z, Yang Y, Dengyan Z, Chunyang Z, Donglei L, Kai W, Song Z. | 04/15/2017 |
| The protein expression of RAP1B and HIF-1 alpha contributed to gastric cancer malignant behavior and poor prognosis. | Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.
Yang Y, Li M, Yan Y, Zhang J, Sun K, Qu JK, Wang JS, Duan XY. | 07/30/2016 |
| Cholera toxin and beta-adrenergic receptor activation phosphorylate Rap1B and inhibit its prenylation and membrane localization. | β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
Wilson JM, Lorimer E, Tyburski MD, Williams CL., Free PMC Article | 07/16/2016 |