| Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway. | Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
Han M, Zhang D, Ji J, Zhang J, Qin M., Free PMC Article | 01/29/2024 |
| CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer. | CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer.
Faam B, Ghadiri AA, Ghaffari MA, Totonchi M, Amouzegar A, Azizi F, Shahbazian H, Hashemitabar M, Fanaei SA, Khorsandi L. | 05/7/2022 |
| Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation. | Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
Shi S, Li J, Li E, Guo W, He Y, Wang J, Zhang Y, Yue L, Wei L., Free PMC Article | 02/26/2022 |
| Downregulation of Rap1GAP Expression Activates the TGF-beta/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells. | Downregulation of Rap1GAP Expression Activates the TGF-β/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells.
Yan Z, Yangyanqiu W, Shuwen H, Jing M, Haihong L, Gong C, Yin J, Qing Z, Weili G., Free PMC Article | 01/22/2022 |
| RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer. | RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer.
Faam B, Ghaffari MA, Khorsandi L, Ghadiri AA, Totonchi M, Amouzegar A, Fanaei SA, Azizi F, Shahbazian HB, Hashemi Tabar M. | 09/18/2021 |
| Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms. | Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
Cai Q, Hosokawa T, Zeng M, Hayashi Y, Zhang M. | 05/1/2021 |
| This is the first mechanistic study of Rap1Gap in breast cancer progression. Decreases in Rap1Gap expression led to changes in adherens junctions via reduction in E-cadherin levels, to cytoskeletal remodeling, and to increases in ERK activation that are correlated with an invasive phenotype in DCIS | Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation.
Shah S, Brock EJ, Jackson RM, Ji K, Boerner JL, Sloane BF, Mattingly RR., Free PMC Article | 12/1/2018 |
| Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer. | Reduced expression of Rap1GAP as a prognostic biomarker for primary gastric cancer patients.
Zhao J, Mai C, Weng D, Chen C, Zhou Z, Liu Y, Zhou Z, Wang P. | 10/20/2018 |
| results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity | Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.
DiStefano PV, Smrcka AV, Glading AJ., Free PMC Article | 08/5/2017 |
| Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC). | Rap1GAP inhibits tumor progression in endometrial cancer.
Tamate M, Tanaka R, Osogami H, Matsuura M, Satohisa S, Iwasaki M, Saito T. | 06/24/2017 |
| Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 in vivo. | PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation.
Wang D, Zhang P, Gao K, Tang Y, Jin X, Zhang Y, Yi Q, Wang C, Yu L., Free PMC Article | 08/1/2015 |
| kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation | Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.
Potla U, Ni J, Vadaparampil J, Yang G, Leventhal JS, Campbell KN, Chuang PY, Morozov A, He JC, D'Agati VD, Klotman PE, Kaufman L., Free PMC Article | 06/7/2014 |
| findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells. | Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP).
Tsygankova OM, Wang H, Meinkoth JL., Free PMC Article | 11/16/2013 |
| Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro. | Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro.
Qiu T, Qi X, Cen J, Chen Z. | 01/26/2013 |
| Downregulation of RAP1GAP in thyroid tumors enhances SRC-dependent signals that regulate cellular architecture and motility. | RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells.
Dong X, Tang W, Stopenski S, Brose MS, Korch C, Meinkoth JL., Free PMC Article | 11/17/2012 |
| Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma. | Rap1GAP regulates renal cell carcinoma invasion.
Kim WJ, Gersey Z, Daaka Y., Free PMC Article | 06/23/2012 |
| Rap1GAP is a more effective inhibitor of cell-matrix adhesion compared to cell-cell adhesion. | Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion.
Vuchak LA, Tsygankova OM, Meinkoth JL., Free PMC Article | 12/24/2011 |
| A polycomb-mediated repression of rap1GAP was demonstrated that involves EZH2, a histone methyltransferase in head and neck cancers. It was also shown that the loss of miR-101 expression correlates with EZH2 upregulation and rap1GAP downregulation. | The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma.
Banerjee R, Mani RS, Russo N, Scanlon CS, Tsodikov A, Jing X, Cao Q, Palanisamy N, Metwally T, Inglehart RC, Tomlins S, Bradford C, Carey T, Wolf G, Kalyana-Sundaram S, Chinnaiyan AM, Varambally S, D'Silva NJ., Free PMC Article | 12/10/2011 |
| These studies establish that the direct physical interaction of Rap1 with KRIT1 enables the translocation of microtubule-sequestered KRIT1 to junctions, thereby supporting junctional integrity and cardiovascular development | A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions.
Liu JJ, Stockton RA, Gingras AR, Ablooglu AJ, Han J, Bobkov AA, Ginsberg MH., Free PMC Article | 11/26/2011 |
| Human kidney cells evidence increased EP4 and decreased Rap1GAP expression levels in the malignant compared with benign samples. | Prostaglandin E2 regulates renal cell carcinoma invasion through the EP4 receptor-Rap GTPase signal transduction pathway.
Wu J, Zhang Y, Frilot N, Kim JI, Kim WJ, Daaka Y., Free PMC Article | 11/26/2011 |
| The expression level of RAP1GAp in myelodysplastic syndrome patients significantly increased as compared with patients with non-malignant blood diseases or AML. | Protein RAP1GAP in human myelodysplastic syndrome detected by flow cytometry and its clinical relevance.
Ika SA, Qi XF, Chen ZX. | 08/27/2011 |
| Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities | Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.
Dai Y, Walker SA, de Vet E, Cook S, Welch HC, Lockyer PJ., Free PMC Article | 08/6/2011 |
| Results suggest that downregulation of Rap1GAP in epithelial tumors where alterations in cell/cell and cell/matrix adhesion are early steps in tumor dissemination supports a role for Rap1GAP depletion in tumor progression. | Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion.
Tsygankova OM, Ma C, Tang W, Korch C, Feldman MD, Lv Y, Brose MS, Meinkoth JL., Free PMC Article | 07/26/2010 |
| Epigenetic or genetic loss of Rap1GAP is very common in thyroid cancer, where these events are sufficient to promote cell proliferation and invasion. | Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors.
Zuo H, Gandhi M, Edreira MM, Hochbaum D, Nimgaonkar VL, Zhang P, Dipaola J, Evdokimova V, Altschuler DL, Nikiforov YE., Free PMC Article | 04/12/2010 |
| model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger | The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.
Kupzig S, Bouyoucef-Cherchalli D, Yarwood S, Sessions R, Cullen PJ., Free PMC Article | 01/21/2010 |