| Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection. | Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
Rinkenberger N, Abrams ME, Matta SK, Schoggins JW, Alto NM, Sibley LD., Free PMC Article | 02/26/2022 |
| we observed frameshift mutations of RARRES3 in 11 cases of colorectal cancer | Mutational intratumoral heterogeneity of a putative tumor suppressor gene RARRES3 in colorectal cancers.
Lee JH, An CH, Yoo NJ, Lee SH. | 11/3/2018 |
| Identified the tumor suppressor RARRES3 as a critical target of G9a. Epigenetic silencing of RARRES3 contributed to the tumor-promoting function of G9a | Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.
Wei L, Chiu DK, Tsang FH, Law CT, Cheng CL, Au SL, Lee JM, Wong CC, Ng IO, Wong CM. | 06/9/2018 |
| this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma | High expression of TIG3 predicts poor survival in patients with primary glioblastoma.
Wang H, Xu H, Xu T, Tan C, Jiang M, Chen Y, Hu X, Zhou J, Shen J, Qin R, Hu D, Huang Q, Wang M, Wang L, Duan D, Yan Y, Chen J. | 07/15/2017 |
| Overexpression of TIG3 suppresses tumor growth in hepatocellular carcinoma | The antitumor effect of TIG3 in liver cancer cells is involved in ERK1/2 inhibition.
Xu Y, Chen T, Liao D, Wu X, Zhong Y, Liu S, Yang H, Nie Y. | 02/18/2017 |
| Letter: Interleukin-22 inhibits tazarotene-induced gene 3 expression in keratinocytes via MAPK-ERK1/2 and JAK2/STAT3 signaling. | Interleukin-22 inhibits tazarotene-induced gene 3 expression in HaCaT cells via MAPK-ERK1/2 and JAK2/STAT3 signaling.
Luo S, Liu X, Zheng Y, Liu Y, Li Y, Wang W, Ni H, Liu Q. | 09/24/2016 |
| findings provide a new insight into the molecular link between p53, protein acylation and Wnt/beta-catenin signaling whereby RARRES3 plays a pivotal role in modulating the acylation status of signaling proteins. | Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells.
Hsu TH, Jiang SY, Chang WL, Eckert RL, Scharadin TM, Chang TC., Free PMC Article | 12/26/2015 |
| the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death. | Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
Wei H, Wang L, Ren X, Yu W, Lin J, Jin C, Xia B. | 07/25/2015 |
| RARRES3 downregulation engages metastasis-initiating capabilities by facilitating adhesion of the tumor cells to the lung parenchyma. | RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation.
Morales M, Arenas EJ, Urosevic J, Guiu M, Fernández E, Planet E, Fenwick RB, Fernández-Ruiz S, Salvatella X, Reverter D, Carracedo A, Massagué J, Gomis RR., Free PMC Article | 02/14/2015 |
| These findings argue that TIG3 is involved in the control of keratinocyte differentiation and that loss of TIG3 in transformed cells contributes to the malignant phenotype. | TIG3: an important regulator of keratinocyte proliferation and survival.
Scharadin TM, Eckert RL., Free PMC Article | 08/23/2014 |
| We show that the C-terminal hydrophobic domain targets intact TIG3 to the plasma membrane, but when isolated as an independent element localizes at the mitochondria and a segment of the N-terminal hydrophilic region targets the centrosome. | Pericentrosomal localization of the TIG3 tumor suppressor requires an N-terminal hydrophilic region motif.
Scharadin TM, Adhikary G, Shaw K, Grun DJB, Xu W, Eckert RL., Free PMC Article | 06/21/2014 |
| Low RIG1 expression is associated with testis cancer. | Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells.
Wu CC, Shyu RY, Wang CH, Tsai TC, Wang LK, Chen ML, Jiang SY, Tsai FM. | 01/26/2013 |
| RIG1 gene is a downstream target of p53 in cancer cell lines | Expression of the class II tumor suppressor gene RIG1 is directly regulated by p53 tumor suppressor in cancer cell lines.
Hsu TH, Chu CC, Jiang SY, Hung MW, Ni WC, Lin HE, Chang TC. | 06/30/2012 |
| Data suggest that pericentrosomal localization of TIG3 is a key event that results in microtubule and microfilament redistribution and pericentrosomal organelle clustering and that leads to cancer cell apoptosis. | TIG3 tumor suppressor-dependent organelle redistribution and apoptosis in skin cancer cells.
Scharadin TM, Jiang H, Jans R, Rorke EA, Eckert RL., Free PMC Article | 02/18/2012 |
| We conclude that TG1-catalysed cross-linking, regulated by TIG3, might play an important role in the formation of neuronal tau inclusions in certain tauopathies | Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies.
Wilhelmus MM, de Jager M, Rozemuller AJ, Brevé J, Bol JG, Eckert RL, Drukarch B., Free PMC Article | 01/21/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesDengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| The tumor suppressors TIG3, HRASLS2 and H-rev107 are involved in the phospholipid metabolism with different physiological roles. | Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes.
Uyama T, Jin XH, Tsuboi K, Tonai T, Ueda N. | 01/21/2010 |
| The NC domain, especially the NC motif, plays the major role in RIG1-mediated pro-apoptotic activity. The RIG1(111-123) dodecapeptide exhibited strong pro-apoptotic activity and has potential as an anticancer drug. | Induction of apoptosis by the retinoid inducible growth regulator RIG1 depends on the NC motif in HtTA cervical cancer cells.
Tsai FM, Shyu RY, Lin SC, Wu CC, Jiang SY., Free PMC Article | 01/21/2010 |
| the TIG3 N-terminal region is required for TIG3-dependent keratinocyte differentiation, and its removal converts TIG3 into a proapoptotic protein | Localization of the TIG3 transglutaminase interaction domain and demonstration that the amino-terminal region is required for TIG3 function as a keratinocyte differentiation regulator.
Jans R, Sturniolo MT, Eckert RL. | 01/21/2010 |
| identification and characterization of the functional RA response element that is responsible for the RA-mediated induction of RIG1 gene | Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter.
Jiang SY, Wu MS, Chen LM, Hung MW, Lin HE, Chang GG, Chang TC. | 01/21/2010 |
| TIG3 is negatively regulated by an activated MEK-ERK signaling pathway in ovarian carcinoma. | Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms.
Lotz K, Kellner T, Heitmann M, Nazarenko I, Noske A, Malek A, Gontarewicz A, Schäfer R, Sers C. | 01/21/2010 |
| TIG3 facilitates the terminal stages in keratinocyte differentiation via activation of type I transglutaminase | A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase.
Sturniolo MT, Dashti SR, Deucher A, Rorke EA, Broome AM, Chandraratna RA, Keepers T, Eckert RL. | 01/21/2010 |
| altered RARRES3 expression may play a role in the carcinogenesis of the liver and biliary tract. | Decreased expression of type II tumor suppressor gene RARRES3 in tissues of hepatocellular carcinoma and cholangiocarcinoma.
Jiang SY, Chou JM, Leu FJ, Hsu YY, Shih YL, Yu JC, Lee MS, Shyu RY., Free PMC Article | 01/21/2010 |
| induction of TIG3 is associated with the suppression of anchorage-independent growth in certain aerodigestive tract cancer cells | Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype.
Higuchi E, Chandraratna RA, Hong WK, Lotan R. | 01/21/2010 |