| p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP. | p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
Ouyang H, Wu S, Li W, Grey MJ, Wu W, Hansen SH., Free PMC Article | 01/5/2024 |
| Spectrum of lymphatic anomalies in patients with RASA1-related CM-AVM. | Spectrum of lymphatic anomalies in patients with RASA1-related CM-AVM.
Mologousis MA, Ostertag-Hill CA, Haimes H, Fishman SJ, Mulliken JB, Liang MG. | 11/20/2023 |
| Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1. | Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1.
Vish KJ, Stiegler AL, Boggon TJ., Free PMC Article | 11/1/2023 |
| Three Cases of Familial Moyamoya Disease with RASA1 Mutations-A Case Report. | Three Cases of Familial Moyamoya Disease with RASA1 Mutations-A Case Report.
Li X, Ma M, Liu R, Yang Y, Yue W. | 03/10/2023 |
| Regulation of IncRNA ZNF667-AS1 in Proliferation and Invasion of Esophageal Squamous Cell Carcinoma Cells via Mediating ceRNA Network. | Regulation of IncRNA ZNF667-AS1 in Proliferation and Invasion of Esophageal Squamous Cell Carcinoma Cells via Mediating ceRNA Network.
Wei L, Gu W, Hu L, Wang K, Huang H, Shen Y. | 08/27/2022 |
| Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation. | Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation.
Choksi F, Weinsheimer S, Nelson J, Pawlikowska L, Fox CK, Zafar A, Mabray MC, Zabramski J, Akers A, Hart BL, Morrison L, McCulloch CE, Kim H., Free PMC Article | 03/26/2022 |
| RASA1 phenotype overlaps with hereditary haemorrhagic telangiectasia: two case reports. | RASA1 phenotype overlaps with hereditary haemorrhagic telangiectasia: two case reports.
El Hajjam M, Mekki A, Palmyre A, Eyries M, Soubrier F, Bourgault Villada I, Ozanne A, Carlier RY, Chinet T. | 02/26/2022 |
| Abnormal H3K27 histone methylation of RASA1 gene leads to unexplained recurrent spontaneous abortion by regulating Ras-MAPK pathway in trophoblast cells. | Abnormal H3K27 histone methylation of RASA1 gene leads to unexplained recurrent spontaneous abortion by regulating Ras-MAPK pathway in trophoblast cells.
Zhang J, Liu X, Gao Y. | 01/22/2022 |
| The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion. | The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion.
Zhang J, Liu X, Gao Y., Free PMC Article | 01/15/2022 |
| CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis. | CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis.
Ji N, Wang Y, Gong X, Ni S, Zhang H., Free PMC Article | 01/15/2022 |
| Down-regulated placental miR-21 contributes to preeclampsia through targeting RASA1. | Down-regulated placental miR-21 contributes to preeclampsia through targeting RASA1.
Dong K, Hou Y, Zhang N, Duan B, Ma A, Zhang Z. | 12/4/2021 |
| Parkes-Weber syndrome related to RASA1 mosaic mutation. | Parkes-Weber syndrome related to RASA1 mosaic mutation.
Boccara O, Eyries M, Pannier S, Ariche-Maman S, Hadj-Rabia S, Coulet F. | 11/27/2021 |
| Prenatal pleural effusions and chylothorax: An unusual presentation for CM-AVM syndrome due to RASA1. | Prenatal pleural effusions and chylothorax: An unusual presentation for CM-AVM syndrome due to RASA1.
D'Amours G, Brunel-Guitton C, Delrue MA, Dubois J, Laberge S, Soucy JF. | 06/5/2021 |
| The GTPase-activating protein p120RasGAP has an evolutionarily conserved ""FLVR-unique"" SH2 domain. | The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
Jaber Chehayeb R, Wang J, Stiegler AL, Boggon TJ., Free PMC Article | 01/16/2021 |
| [Neonatal capillary malformation-arteriovenous malformation complicated with acute heart failure: a case report and literature review]. | [Neonatal capillary malformation-arteriovenous malformation complicated with acute heart failure: a case report and literature review].
Wang LJ, Sun JH, Bei F. | 11/21/2020 |
| CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1. | CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1.
Xiao W, Zheng S, Zou Y, Yang A, Xie X, Tang H, Xie X., Free PMC Article | 10/24/2020 |
| RASA1 mosaic mutations can cause capillary malformation-arteriovenous malformation. Even low-level mosaicism can cause the classical phenotype and increased risk for offspring. | RASA1 mosaic mutations in patients with capillary malformation-arteriovenous malformation.
Revencu N, Fastre E, Ravoet M, Helaers R, Brouillard P, Bisdorff-Bresson A, Chung CWT, Gerard M, Dvorakova V, Irvine AD, Boon LM, Vikkula M. | 06/13/2020 |
| we report for the first time the presence of RASA1 constitutional mosaicism in CM-AVM. Constitutional mosaicism has implications for accurate molecular diagnosis and recurrence risk and helps to explain the great phenotypic variability in CM-AVM. | Constitutional mosaicism in RASA1-related capillary malformation-arteriovenous malformation.
Gordo G, Rodriguez-Laguna L, Agra N, Mendez P, Feito M, Lapunzina P, Lopez-Gutierrez JC, Martinez-Glez V. | 05/23/2020 |
| Cancer genomic and functional data nominate concurrent RASA1/NF1 loss-of-function mutations as a strong mitogenic driver in NSCLC, which may sensitize to trametinib | RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.
Hayashi T, Desmeules P, Smith RS, Drilon A, Somwar R, Ladanyi M., Free PMC Article | 10/5/2019 |
| The results suggested that miRNA4530 suppresses cell proliferation and enhances apoptosis by targeting RASA1 via the ERK/MAPK and PI3K/AKT signaling pathways. | MicroRNA‑4530 suppresses cell proliferation and induces apoptosis by targeting RASA1 in human umbilical vein endothelial cells.
Jing L, Li H, Zhang T, Lu J, Zhong L., Free PMC Article | 08/3/2019 |
| Data suggest that the anti-oncogenic function of circular RNA circ-ITCH (circ-ITCH) is via the circ-ITCH-miR-145-RASA1 (RAS p21 protein activator (GTPase activating protein) 1) axis in vitro and in vivo. | The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling.
Hu J, Wang L, Chen J, Gao H, Zhao W, Huang Y, Jiang T, Zhou J, Chen Y. | 06/1/2019 |
| Our data suggest that screening for large RASA1 deletions and duplications in this disorder is important and suggest that NGS multi-gene panel testing is beneficial for the molecular diagnosis of cases with complex vascular phenotypes. | Expanding the clinical and molecular findings in RASA1 capillary malformation-arteriovenous malformation.
Wooderchak-Donahue WL, Johnson P, McDonald J, Blei F, Berenstein A, Sorscher M, Mayer J, Scheuerle AE, Lewis T, Grimmer JF, Richter GT, Steeves MA, Lin AE, Stevenson DA, Bayrak-Toydemir P., Free PMC Article | 03/9/2019 |
| Study found that RASA1, a known target of miR-132, was downregulated in human dermal fibroblasts upon miR-132 overexpression which contributes to the pro-migratory function of miR-132 in fibroblasts. | MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing.
Li X, Li D, Wikstrom JD, Pivarcsi A, Sonkoly E, Ståhle M, Landén NX., Free PMC Article | 03/9/2019 |
| miR21 regulated cell proliferation, migration, invasion and tumor growth of esophageal squamous cell carcinoma by directly targeting RASA1, which may have been achieved via regulation of Snail and vimentin. | MicroRNA‑21 regulates the biological behavior of esophageal squamous cell carcinoma by targeting RASA1.
Chen X, Cai S, Li B, Zhang X, Li W, Liang H, Cao X, Wang L, Wu Z., Free PMC Article | 03/9/2019 |
| A somatic RASA1 mutation in addition to the germline RASA1 mutation, was detected within endothelial cells in capillary malformation-arteriovenous malformation. | Somatic second hit mutation of RASA1 in vascular endothelial cells in capillary malformation-arteriovenous malformation.
Lapinski PE, Doosti A, Salato V, North P, Burrows PE, King PD., Free PMC Article | 09/22/2018 |