| RASGRF1-rearranged Cutaneous Melanocytic Neoplasms With Spitzoid Cytomorphology: A Clinicopathologic and Genetic Study of 3 Cases. | RASGRF1-rearranged Cutaneous Melanocytic Neoplasms With Spitzoid Cytomorphology: A Clinicopathologic and Genetic Study of 3 Cases.
Goto K, Pissaloux D, Fraitag S, Amini M, Vaucher R, Tirode F, de la Fouchardière A. | 04/30/2022 |
| Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons. | Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons.
Cifelli JL, Berg KR, Yang J., Free PMC Article | 07/10/2021 |
| Low RASGRF1 expression due to hypermethylation is associated with Colorectal Cancer. | RASGRF1 Hypermethylation, a Putative Biomarker of Colorectal Cancer.
Chen H, Xu Z, Yang B, Zhou X, Kong H. | 09/22/2018 |
| Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia. | Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania.
Kunceviciene E, Sriubiene M, Liutkeviciene R, Miceikiene IT, Smalinskiene A., Free PMC Article | 06/23/2018 |
| genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population. | Assessment of BicC family RNA binding protein 1 and Ras protein specific guanine nucleotide releasing factor 1 as candidate genes for high myopia: A case-control study.
Hepei L, Mingkun X, Li W, Jin W., Free PMC Article | 12/23/2017 |
| Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF. | RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras.
Wu RF, Liao C, Hatoum H, Fu G, Ochoa CD, Terada LS., Free PMC Article | 06/24/2017 |
| Data show that microRNA miR-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression. | miR-137 acts as a tumor suppressor in astrocytoma by targeting RASGRF1.
Deng D, Xue L, Shao N, Qu H, Wang Q, Wang S, Xia X, Yang Y, Zhi F. | 02/18/2017 |
| Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. | Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians.
Gavino C, Hamel N, Zeng JB, Legault C, Guiot MC, Chankowsky J, Lejtenyi D, Lemire M, Alarie I, Dufresne S, Boursiquot JN, McIntosh F, Langelier M, Behr MA, Sheppard DC, Foulkes WD, Vinh DC. | 09/3/2016 |
| Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis) | Polymorphism in the RASGRF1 gene with high myopia: A meta-analysis.
Chen T, Shan G, Ma J, Zhong Y., Free PMC Article | 06/28/2016 |
| Rasgrf-1 is a novel GEF protein that has a role in BCR signaling and its overexpression further activates the Ras/Erk/MAPK pathway in CLL specimens. | Amplification of B cell receptor-Erk signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia.
Liao W, Jordaan G, Coriaty N, Sharma S. | 08/22/2015 |
| In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia. | Evaluating the association between pathological myopia and SNPs in RASGRF1. ACTC1 and GJD2 genes at chromosome 15q14 and 15q25 in a Chinese population.
Chen CD, Yu ZQ, Chen XL, Zhou JQ, Zhou XT, Sun XH, Chu RY. | 08/8/2015 |
| CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. | CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.
Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu YM, Yang L, Guan JH, Xu GT, Lin X., Free PMC Article | 02/21/2015 |
| ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. | Association between ZIC2, RASGRF1, and SHISA6 genes and high myopia in Japanese subjects.
Oishi M, Yamashiro K, Miyake M, Akagi-Kurashige Y, Kumagai K, Nakata I, Nakanishi H, Yoshikawa M, Oishi A, Gotoh N, Tsujikawa A, Nagahama Study Group, Yamada R, Matsuda F, Yoshimura N. | 01/11/2014 |
| Decreased expression of Ras-GRF1 could be involved in the pathogenesis of human temporal lobe epilepsy. | Decreased expression of Ras-GRF1 in the brain tissue of the intractable epilepsy patients and experimental rats.
Zhu Q, Wang L, Xiao Z, Xiao F, Luo J, Zhang X, Peng X, Wang X, Sun H. | 06/15/2013 |
| Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer. | Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer.
Takamaru H, Yamamoto E, Suzuki H, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Suzuki R, Yamamoto H, Kai M, Tokino T, Sugai T, Imai K, Toyota M, Shinomura Y. | 03/23/2013 |
| RasGRF1 plays an important role in alveolar rhabdomyosarcoma pathogenesis | RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas.
Tarnowski M, Schneider G, Amann G, Clark G, Houghton P, Barr FG, Kenner L, Ratajczak MZ, Kucia M., Free PMC Article | 01/26/2013 |
| Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. | RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P. | 09/10/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.
Hysi PG, Young TL, Mackey DA, Andrew T, Fernández-Medarde A, Solouki AM, Hewitt AW, Macgregor S, Vingerling JR, Li YJ, Ikram MK, Fai LY, Sham PC, Manyes L, Porteros A, Lopes MC, Carbonaro F, Fahy SJ, Martin NG, van Duijn CM, Spector TD, Rahi JS, Santos E, Klaver CC, Hammond CJ, Hysi PG, Young TL, Mackey DA, Andrew T, Fernández-Medarde A, Solouki AM, Hewitt AW, Macgregor S, Vingerling JR, Li YJ, Ikram MK, Fai LY, Sham PC, Manyes L, Porteros A, Lopes MC, Carbonaro F, Fahy SJ, Martin NG, van Duijn CM, Spector TD, Rahi JS, Santos E, Klaver CC, Hammond CJ., Free PMC Articles: PMC4115148, PMC4115148 | 12/5/2010 |
| Single Nucleotide Polymorphisms in RASGRF1 is associated with refractive errors and myopia. | A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.
Hysi PG, Young TL, Mackey DA, Andrew T, Fernández-Medarde A, Solouki AM, Hewitt AW, Macgregor S, Vingerling JR, Li YJ, Ikram MK, Fai LY, Sham PC, Manyes L, Porteros A, Lopes MC, Carbonaro F, Fahy SJ, Martin NG, van Duijn CM, Spector TD, Rahi JS, Santos E, Klaver CC, Hammond CJ, Hysi PG, Young TL, Mackey DA, Andrew T, Fernández-Medarde A, Solouki AM, Hewitt AW, Macgregor S, Vingerling JR, Li YJ, Ikram MK, Fai LY, Sham PC, Manyes L, Porteros A, Lopes MC, Carbonaro F, Fahy SJ, Martin NG, van Duijn CM, Spector TD, Rahi JS, Santos E, Klaver CC, Hammond CJ., Free PMC Articles: PMC4115148, PMC4115148 | 10/30/2010 |
| Farnesylated or geranylgeranylated TC21 can be activated by RasGRF1 due to its pleckstrin homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes. | Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors.
Calvo F, Crespo P., Free PMC Article | 04/12/2010 |
| Enhanced expression and post-translational modification of RasGRF1 contributes to MMP-3 production in RA | The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue.
Abreu JR, de Launay D, Sanders ME, Grabiec AM, van de Sande MG, Tak PP, Reedquist KA., Free PMC Article | 01/21/2010 |
| zoledronate induces DNA damage and S phase arrest, accompanied by activation of the ATM/Chk1/cdc25 pathway in a human osteosarcoma cell line | Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.
Iguchi T, Miyakawa Y, Saito K, Nakabayashi C, Nakanishi M, Saya H, Ikeda Y, Kizaki M. | 01/21/2010 |
| RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex | Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.
Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Muñoz MT, Egea G, Lafarga M, Crespo P., Free PMC Article | 01/21/2010 |
| Taken together our results demonstrate that U2AF35a is essential for HeLa cell division and suggest a novel role for both U2AF35 protein isoforms as regulators of alternative splicing of a specific subset of genes. | RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts.
Pacheco TR, Moita LF, Gomes AQ, Hacohen N, Carmo-Fonseca M., Free PMC Article | 01/21/2010 |
| Vitamin K3 inhibitor H32 differentially inhibited growth of normal and liver tumor cells by preferentially inhibiting the actions of Cdc25 phosphatases | H32, a non-quinone sulfone analog of vitamin K3, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK.
Kar S, Wang M, Ham SW, Carr BI. | 01/21/2010 |