| Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients. | Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients.
Lin Q, Qiu M, Wei X, Xiang Z, Zhou Z, Ji I, Liang X, Zhou X, Wen Q, Liu Y, Yu H. | 05/30/2023 |
| AnxA6 may be a reliable biomarker for distant relapse-free survival and response of triple negative breast cancer (TNBC) patients to chemotherapy, and that the reciprocal expression of AnxA6 and GRF2 can reliably delineate TNBCs into rapidly growing and invasive subsets which may be more relevant for subset-specific therapeutic interventions. | Reciprocal expression of Annexin A6 and RasGRF2 discriminates rapidly growing from invasive triple negative breast cancer subsets.
Korolkova OY, Widatalla SE, Whalen DS, Nangami GN, Abimbola A, Williams SD, Beasley HK, Reisenbichler E, Washington MK, Ochieng J, Mayer IA, Lehmann BD, Sakwe AM., Free PMC Article | 08/12/2020 |
| High RASGRF2 expression is associated with migration and invasion of colorectal cancer. | RasGRF2 promotes migration and invasion of colorectal cancer cells by modulating expression of MMP9 through Src/Akt/NF-κB pathway.
Lu P, Chen J, Yan L, Yang L, Zhang L, Dai J, Hao Z, Bai T, Xi Y, Li Y, Kang Z, Xv J, Sun G, Yang T., Free PMC Article | 07/4/2020 |
| RASGRF2-int is significantly associated with drug addiction. | Human Endogenous Retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model.
Karamitros T, Hurst T, Marchi E, Karamichali E, Georgopoulou U, Mentis A, Riepsaame J, Lin A, Paraskevis D, Hatzakis A, McLauchlan J, Katzourakis A, Magiorkinis G., Free PMC Article | 11/17/2018 |
| this genetic association study represents the first to show an association of the RASGRF2 G>A (rs26907) polymorphism with Alcoholic Liver Cirrhosis in men, particularly in the subgroup of patients with alcohol dependence. The findings suggest the potential relevance of the RAS gene family in alcoholism and Alcoholic Liver Cirrhosis. | A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men.
Novo-Veleiro I, Cieza-Borrella C, Pastor I, Chamorro AJ, Laso FJ, González-Sarmiento R, Marcos M., Free PMC Article | 07/1/2017 |
| Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF. | RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras.
Wu RF, Liao C, Hatoum H, Fu G, Ochoa CD, Terada LS., Free PMC Article | 06/24/2017 |
| these results suggest that betaarrestin1 regulates rasgrf2 gene expression and Rac activation to affect membrane protrusion and cell migration and invasion. | βArrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility.
Ma X, Espana-Serrano L, Kim WJ, Thayele Purayil H, Nie Z, Daaka Y., Free PMC Article | 06/28/2014 |
| Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 genes. | A genome-wide association study for malignant mesothelioma risk.
Cadby G, Mukherjee S, Musk AW, Reid A, Garlepp M, Dick I, Robinson C, Hui J, Fiorito G, Guarrera S, Beilby J, Melton PE, Moses EK, Ugolini D, Mirabelli D, Bonassi S, Magnani C, Dianzani I, Matullo G, Robinson B, Creaney J, Palmer LJ. | 04/19/2014 |
| RASGRF2 has a role in the regulation of mesolimbic dopamine neuron activity, reward response, and alcohol use and abuse | RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release.
Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, Nymberg C, Banaschewski T, Barker GJ, Büchel C, Carvalho F, Conrod PJ, Desrivières S, Fauth-Bühler M, Fernandez-Medarde A, Flor H, Gallinat J, Garavan H, Bokde AL, Heinz A, Ittermann B, Lathrop M, Lawrence C, Loth E, Lourdusamy A, Mann KF, Martinot JL, Nees F, Palkovits M, Paus T, Pausova Z, Rietschel M, Ruggeri B, Santos E, Smolka MN, Staehlin O, Jarvelin MR, Elliott P, Sommer WH, Mameli M, Müller CP, Spanagel R, Girault JA, Schumann G, IMAGEN Consortium., Free PMC Article | 03/2/2013 |
| Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. | RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Calvo F, Sanz-Moreno V, Agudo-Ibáñez L, Wallberg F, Sahai E, Marshall CJ, Crespo P. | 09/10/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Farnesylated but not geranylgeranylated TC21 can be activated by RasGRF2 due to its pleckstrin homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes. | Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors.
Calvo F, Crespo P., Free PMC Article | 04/12/2010 |
| These data reveal unexpected negative roles for Vav1 and RasGRF2 in different stages of T-cell lymphoma progression. | The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.
Ruiz S, Santos E, Bustelo XR., Free PMC Article | 03/22/2010 |
| These results identify RasGRF2 as an additional component of the signaling machinery involved in T-cell receptor- and NF-AT-mediated immune responses. | RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.
Ruiz S, Santos E, Bustelo XR., Free PMC Article | 01/21/2010 |
| RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex | Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.
Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Muñoz MT, Egea G, Lafarga M, Crespo P., Free PMC Article | 01/21/2010 |
| Aberrant methylation of RASGRF2 is associated with human non-small cell lung cancer | Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer.
Chen H, Suzuki M, Nakamura Y, Ohira M, Ando S, Iida T, Nakajima T, Nakagawara A, Kimura H. | 01/21/2010 |