| NUDT16 regulates CtIP PARylation to dictate homologous recombination repair. | NUDT16 regulates CtIP PARylation to dictate homologous recombination repair.
Zhang Z, Samsa WE, Gong Z., Free PMC Article | 05/8/2024 |
| A novel RBBP8(p.E281*) germline mutation is a predisposing mutation in familial hereditary cancer syndrome. | A novel RBBP8(p.E281*) germline mutation is a predisposing mutation in familial hereditary cancer syndrome.
Yan J, Wu J, Wang Y, Di X, Jiang H, Wen D, Li D, Zhang S. | 10/11/2023 |
| Prognostic Significance of mRNA Expression RBBP8 or Its Methylation in Gliomas. | Prognostic Significance of mRNA Expression RBBP8 or Its Methylation in Gliomas.
Liu Z, Cheng X, Lin S, Han Z, Jin H, Luan Z, Li P, Liang W, Qian R, Gao Y. | 01/14/2023 |
| SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination. | SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination.
Jeong SY, Hariharasudhan G, Kim MJ, Lim JY, Jung SM, Choi EJ, Chang IY, Kee Y, You HJ, Lee JH., Free PMC Article | 10/22/2022 |
| The mechanism of radiotherapy for lung adenocarcinoma in promoting protein SIRT6-mediated deacetylation of RBBP8 to enhance the sensitivity of targeted therapy. | The mechanism of radiotherapy for lung adenocarcinoma in promoting protein SIRT6-mediated deacetylation of RBBP8 to enhance the sensitivity of targeted therapy.
Wang J, Sheng Z, Dong Z, Wu Q, Cai Y., Free PMC Article | 10/8/2022 |
| The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells. | The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
Averbeck NB, Barent C, Jakob B, Syzonenko T, Durante M, Taucher-Scholz G., Free PMC Article | 09/3/2022 |
| IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma. | IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma.
Liu M, Zhang Y, Wu Y, Jin J, Cao Y, Fang Z, Geng L, Yang L, Yu M, Bu Z, Ji Y, Shan H, Zou Z, Liu L, Wang Y, Zhang Y, Tong Y, Xu H, Lei H, Liu W, Gao F, Wu Y., Free PMC Article | 04/23/2022 |
| RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor. | RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor.
Bolck HA, Przetocka S, Meier R, von Aesch C, Zurfluh C, Hänggi K, Spegg V, Altmeyer M, Stebler M, Nørrelykke SF, Horvath P, Sartori AA, Porro A., Free PMC Article | 04/16/2022 |
| A 24-generation-old founder mutation impairs splicing of RBBP8 in Pakistani families affected with Jawad syndrome. | A 24-generation-old founder mutation impairs splicing of RBBP8 in Pakistani families affected with Jawad syndrome.
Kaygusuz E, Khayyat AIA, Abdullah U, Budde BS, Asif M, Ahmed I, Makhdoom EUH, Sur-Erdem I, Baig JM, Khan MMA, Toliat MR, Becker C, Anwar H, Iqbal M, Fischer S, Jameel M, Sher M, Tariq M, Malik NA, Noegel AA, Hassan MJ, Thiele H, Tinschert S, Eichinger L, Höning S, Baig SM, Nürnberg P, Hussain MS. | 02/5/2022 |
| CtIP suppresses primary microRNA maturation and promotes metastasis of colon cancer cells in a xenograft mouse model. | CtIP suppresses primary microRNA maturation and promotes metastasis of colon cancer cells in a xenograft mouse model.
Ren J, Wu Y, Wang Y, Zhao Y, Li Y, Hao S, Lin L, Zhang S, Xu X, Wang H., Free PMC Article | 08/21/2021 |
| Prognosis value of RBBP8 expression in plasma cell myeloma. | Prognosis value of RBBP8 expression in plasma cell myeloma.
Zhang W, Song Y, He X, Liu X, Zhang Y, Yang Z, Yang P, Wang J, Hu K, Liu W, Zhang X, Yuan X, Jing H., Free PMC Article | 05/15/2021 |
| SCF(SKP2) regulates APC/C(CDH1)-mediated degradation of CTIP to adjust DNA-end resection in G2-phase. | SCF(SKP2) regulates APC/C(CDH1)-mediated degradation of CTIP to adjust DNA-end resection in G(2)-phase.
Li F, Mladenov E, Mortoga S, Iliakis G., Free PMC Article | 03/27/2021 |
| SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection. | SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection.
Locke AJ, Hossain L, McCrostie G, Ronato DA, Fitieh A, Rafique TA, Mashayekhi F, Motamedi M, Masson JY, Ismail IH., Free PMC Article | 02/6/2021 |
| Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability. | Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability.
Zarrizi R, Higgs MR, Voßgröne K, Rossing M, Bertelsen B, Bose M, Kousholt AN, Rösner H, Network TC, Ejlertsen B, Stewart GS, Nielsen FC, Sørensen CS., Free PMC Article | 02/6/2021 |
| RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer. | RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.
Yu Y, Chen L, Zhao G, Li H, Guo Q, Zhu S, Li P, Min L, Zhang S. | 11/28/2020 |
| Phosphorylated CtIP bridges DNA to promote annealing of broken ends. | Phosphorylated CtIP bridges DNA to promote annealing of broken ends.
Öz R, Howard SM, Sharma R, Törnkvist H, Ceppi I, Kk S, Kristiansson E, Cejka P, Westerlund F., Free PMC Article | 10/24/2020 |
| DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP. | DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP.
Deshpande RA, Myler LR, Soniat MM, Makharashvili N, Lee L, Lees-Miller SP, Finkelstein IJ, Paull TT., Free PMC Article | 09/19/2020 |
| The internal region of CtIP negatively regulates DNA end resection. | The internal region of CtIP negatively regulates DNA end resection.
Howard SM, Ceppi I, Anand R, Geiger R, Cejka P., Free PMC Article | 08/22/2020 |
| CtIP contributes to non-homologous end joining formation through interacting with ligase IV and promotion of TMZ resistance in glioma cells. | CtIP contributes to non-homologous end joining formation through interacting with ligase IV and promotion of TMZ resistance in glioma cells.
Yang B, Han N, Sun J, Jiang H, Xu HY. | 08/15/2020 |
| CtlP expression is regulated by both ACL1 and eIF4A1 proteins which cooperates to help stabilizing the most abundant splicing form of CtIP mRNA. In fact, the G4 5'-UTR sequence of CtIP is necessary for both eIF4A1 and ALC1 functions. | ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection.
Mejías-Navarro F, Rodríguez-Real G, Ramón J, Camarillo R, Huertas P., Free PMC Article | 08/1/2020 |
| Study revealed that phosphorylated CtIP (pCtIP) dramatically stimulates the motor activity of DNA2. This accelerates degradation of RPA-coated ssDNA by DNA2, showing the need for the motor activity of DNA2 to facilitate resection. CtIP is thus a cofactor not only of MRE11, but also of DNA2, and domains of CtIP required for the stimulation of MRE11-RAD50-NBS1 (MRN) complex and DNA2 are physically separate. | CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection.
Ceppi I, Howard SM, Kasaciunaite K, Pinto C, Anand R, Seidel R, Cejka P., Free PMC Article | 08/1/2020 |
| CSB interacts with BRCA1 to promote DNA end resection | CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection.
Batenburg NL, Walker JR, Coulombe Y, Sherker A, Masson JY, Zhu XD., Free PMC Article | 05/16/2020 |
| Data show that retinoblastoma binding protein 8 (CtIP) is a tetrameric protein adopting a dumbbell architecture in which DNA binding domains are connected by long coiled-coils. | CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair.
Wilkinson OJ, Martín-González A, Kang H, Northall SJ, Wigley DB, Moreno-Herrero F, Dillingham MS., Free PMC Article | 04/25/2020 |
| CtIP is required for faithful replication through telomeres via its roles at stalled replication tracts. | CtIP is essential for telomere replication.
Stroik S, Kurtz K, Hendrickson EA., Free PMC Article | 12/21/2019 |
| The N-terminus of CTCF is able to bind to only MRE11 and its C-terminus is incapable of binding to MRE11 and CtIP, thereby resulting in compromised CtIP recruitment, DSB resection and HR. Overall, this suggests an important function of CTCF in DNA end resection through the recruitment of CtIP at DSBs. | CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks.
Hwang SY, Kang MA, Baik CJ, Lee Y, Hang NT, Kim BG, Han JS, Jeong JH, Park D, Myung K, Lee JS., Free PMC Article | 12/14/2019 |