| REG1A protects retinal photoreceptors from blue light damage. | REG1A protects retinal photoreceptors from blue light damage.
Xu ZH, Zhang H, Zhang CJ, Yu SJ, Yuan J, Jin K, Jin ZB. | 09/23/2023 |
| The role of pancreatic stone protein as a prognostic factor for COVID-19 patients. | The role of pancreatic stone protein as a prognostic factor for COVID-19 patients.
Lagadinou M, Paraskevas T, Velissaris D, Michailides C, Eleftherakis G, Sampsonas F, Siakallis G, Assimakopoulos SF, Marangos M. | 10/15/2022 |
| Protective and anti-inflammatory role of REG1A in inflammatory bowel disease induced by JAK/STAT3 signaling axis. | Protective and anti-inflammatory role of REG1A in inflammatory bowel disease induced by JAK/STAT3 signaling axis.
Mao H, Jia J, Sheng J, Zhang S, Huang K, Li H, He F. | 06/26/2021 |
| Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas. | Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas.
Graf R. | 02/27/2021 |
| Carboxypeptidase A1 and regenerating islet-derived 1alpha as new markers for pancreatic acinar cell carcinoma. | Carboxypeptidase A1 and regenerating islet-derived 1α as new markers for pancreatic acinar cell carcinoma.
Said S, Kurtin PJ, Nasr SH, Graham RP, Dasari S, Vrana JA, Yasir S, Torbenson MS, Zhang L, Mounajjed T, Eric Chen ZM, Lee HE, Wu TT. | 02/20/2021 |
| Association of Serum PSP/REG Ialpha with Renal Function in Type 2 Diabetes Mellitus. | Association of Serum PSP/REG Iα with Renal Function in Type 2 Diabetes Mellitus.
Zhu H, Zhu X, Lin H, Liu D, Dai Y, Su X, Li L., Free PMC Article | 02/20/2021 |
| Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population. | Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population.
Xing H, Chen X, Sun H, Han Y, Ding L, Chen X., Free PMC Article | 11/21/2020 |
| Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells. | Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.
Stone S, Abreu D, Mahadevan J, Asada R, Kries K, Graf R, Marshall BA, Hershey T, Urano F., Free PMC Article | 10/3/2020 |
| TP53E10 but not TP53E3 cells exhibited aberrant transcriptional activity of regenerating family member 1-alpha (REG1A) and expression of REG1A, resulting in the acquisition of enhanced malignant potential. In conclusion, we demonstrated for the first time that TP53 genomic mutation into human colon cancer cells affects the malignant potential. | TP53 Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer.
Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M. | 05/2/2020 |
| serum PSP/REG Ialpha levels could be a novel biomarker for assessment of renal function in pregnant women. | Association of Serum PSP/REG Iα with Renal Function in Pregnant Women.
Zhu X, Dong B, Reding T, Peng Y, Lin H, Zhi M, Han M, Graf R, Li L., Free PMC Article | 11/23/2019 |
| An association was found between REG-1alpha expression and tau hyper-phosphorylation in brain samples from patients with neurodegenerative disease. | Regenerating islet-derived 1α (REG-1α) protein increases tau phosphorylation in cell and animal models of tauopathies.
Moussaed M, Huc-Brandt S, Cubedo N, Silhol M, Murat S, Lebart MC, Kovacs G, Verdier JM, Trousse F, Rossel M, Marcilhac A. | 09/21/2019 |
| predicted results suggested that the Reg-mediated JAK/STAT, NF-kappaB, MAPK (ERK1/2, P38 and JNK), PLC, and PI3K/AKT signaling pathways may account for the activated inflammation and cell proliferation, and the attenuated apoptosis and cell death during the occurrence of AHF and H | Comparative Analysis of Expression Profiles of Reg Signaling Pathways-Related Genes Between AHF and HCC.
Wang G, Cheng L, Chen M, Zhao C, Gao M, Huang T, Chu P, Xu C. | 06/29/2019 |
| Serum levels of PCT and PSP are promising biomarkers for early diagnosis of pediatric acute osteomyelitis. | Procalcitonin and Pancreatic Stone Protein Function as Biomarkers in Early Diagnosis of Pediatric Acute Osteomyelitis.
Cui C, Fu M, Gao B., Free PMC Article | 07/28/2018 |
| PSP/reg levels are significantly up-regulated in diabetic kidney disease patients and might be related to renal injury | Elevated serum level of pancreatic stone protein/regenerating protein (PSP/reg) is observed in diabetic kidney disease.
Li L, Jia D, Graf R, Yang J., Free PMC Article | 04/7/2018 |
| Both univariate and multivariate analysis demonstrated that REG1A expression was associated with OS and PFS, and conducted harmful effects on nasopharyngeal carcinoma progression and survival. This study suggested that REG1A expression could serve as an independent adverse factor for survival in nasopharyngeal carcinoma. | Role of regenerating gene IA expression on local invasion and survival in nasopharyngeal carcinoma.
Xing H, Chen X, Han Y., Free PMC Article | 12/9/2017 |
| Reg I may play a role in the maintenance of mucosal barrier function by inducing tight junction proteins such as claudins 3 and 4. | Role of regenerating gene I in claudin expression and barrier function in the small intestine.
Kitayama Y, Fukui H, Hara K, Eda H, Kodani M, Yang M, Sun C, Yamagishi H, Tomita T, Oshima T, Watari J, Takasawa S, Miwa H. | 07/1/2017 |
| the prognostic value of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and pancreatic stone protein (PSP) in children with sepsis, was investigated. | Prognostic Value of High-Sensitivity C-Reactive Protein, Procalcitonin and Pancreatic Stone Protein in Pediatric Sepsis.
Wu Q, Nie J, Wu FX, Zou XL, Chen FY., Free PMC Article | 04/29/2017 |
| REG1alpha was overexpressed in bladder cancer tissues compared with adjacent normal samples. Downregulation of REG1alpha expression in urothelial bladder cancer can reduce tumor growth, migration, invasion and angiogenesis. | Decreased REG1α expression suppresses growth, invasion and angiogenesis of bladder cancer.
Geng J, Fan J, Wang Q, Zhang XP, Kang L, Li QY, Xu YF, Peng B, Zheng JH, Yao XD. | 04/22/2017 |
| REG-I is expressed in head and neck squamous cell carcinoma and is associated with a longer survival status. | Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.
Aboshanif M, Kawasaki Y, Omori Y, Suzuki S, Honda K, Motoyama S, Ishikawa K., Free PMC Article | 02/18/2017 |
| We have established a novel, three-protein biomarker panel that is able to detect patients with early-stage pancreatic cancer in urine specimens:LYVE-1, REG1A, and TFF1 were selected as candidate biomarkers | Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.
Radon TP, Massat NJ, Jones R, Alrawashdeh W, Dumartin L, Ennis D, Duffy SW, Kocher HM, Pereira SP, Guarner posthumous L, Murta-Nascimento C, Real FX, Malats N, Neoptolemos J, Costello E, Greenhalf W, Lemoine NR, Crnogorac-Jurcevic T., Free PMC Article | 05/21/2016 |
| post-operative serum PSP levels were significantly associated with the presence of infection in both the on-pump and off-pump setting. | Pancreatic stone protein predicts postoperative infection in cardiac surgery patients irrespective of cardiopulmonary bypass or surgical technique.
Klein HJ, Csordas A, Falk V, Slankamenac K, Rudiger A, Schönrath F, Rodriguez Cetina Biefer H, Starck CT, Graf R., Free PMC Article | 02/27/2016 |
| REG Ialpha protein may play a role in angiogenesis during progression of gastric cancer | Effect of REG Iα protein on angiogenesis in gastric cancer tissues.
Hara K, Fukui H, Sun C, Kitayama Y, Eda H, Yamasaki T, Kondo T, Tomita T, Oshima T, Watari J, Fujimori T, Miwa H. | 01/16/2016 |
| PSP/reg is significantly up-regulated in T2DM patients, and PSP/reg levels are related to the duration of diabetes. | Pancreatic stone protein/regenerating protein (PSP/reg): a novel secreted protein up-regulated in type 2 diabetes mellitus.
Yang J, Li L, Raptis D, Li X, Li F, Chen B, He J, Graf R, Sun Z. | 12/19/2015 |
| the expression of REG Ialpha and REG Ibeta may be upregulated in human beta cells under inflammatory conditions through the JAK/STAT pathway | Synergistic activations of REG I α and REG I β promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic β cells.
Yamauchi A, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takeda M, Yoshimoto K, Miyaoka T, Fujimura T, Tsujinaka H, Tsuchida C, Ota H, Takasawa S., Free PMC Article | 10/31/2015 |
| Collectively, these findings suggest that REG Ialpha activates c-Jun via the JNK and ERK pathway, thereby enhancing radiosensitivity | REG Iα activates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells.
Wakita A, Motoyama S, Sato Y, Koyota S, Usami S, Yoshino K, Sasaki T, Imai K, Saito H, Minamiya Y. | 10/31/2015 |