| RXR agonist, Bexarotene, effectively reduces drug resistance via regulation of RFX1 in embryonic carcinoma cells. | RXR agonist, Bexarotene, effectively reduces drug resistance via regulation of RFX1 in embryonic carcinoma cells.
Issac J, Raveendran PS, Kunnummal M, Angelin M, Ravindran S, Basu B, Das AV. | 08/20/2023 |
| RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells. | RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.
Chirichella M, Bianchi N, Džafo E, Foli E, Gualdrini F, Kenyon A, Natoli G, Monticelli S., Free PMC Article | 03/26/2022 |
| RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions. | RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions.
Mizukawa T, Nishida T, Akashi S, Kawata K, Kikuchi S, Kawaki H, Takigawa M, Kamioka H, Kubota S. | 12/4/2021 |
| the recruitment of PP1c to promoters may be a mechanism by which RFX1 regulates the target genes. | Recruitment of the protein phosphatase-1 catalytic subunit to promoters by the dual-function transcription factor RFX1.
Lubelsky Y, Shaul Y. | 11/9/2019 |
| Results show that RFX1 expression deficiency leads to the overexpression of TLR4 and the activation of CD14(+) monocytes in coronary artery disease (CAD) patients by regulating DNA methylation and histone modifications, which highlights the vital role of RFX1 in the pathogenesis of CAD. | RFX1 downregulation contributes to TLR4 overexpression in CD14(+) monocytes via epigenetic mechanisms in coronary artery disease.
Du P, Gao K, Cao Y, Yang S, Wang Y, Guo R, Zhao M, Jia S., Free PMC Article | 08/24/2019 |
| RFX1 interacts with the D sequence of adeno-associated virus inverted terminal repeat and regulates AAV transduction. | RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.
Julien L, Chassagne J, Peccate C, Lorain S, Piétri-Rouxel F, Danos O, Benkhelifa-Ziyyat S., Free PMC Article | 11/17/2018 |
| RFX1 expression was significantly lower in HCC tissues compared to the corresponding non-tumor tissues. In vitro studies suggested that knocking down RFX1 facilitated HCC cell invasion, while overexpression of RFX1 reduced the invasion of HCC cells. RFX1 regulated expression of some epithelial-mesenchymal transition markers. | Downregulation of RFX1 predicts poor prognosis of patients with small hepatocellular carcinoma.
Liu Y, Jiang P, Wang G, Liu X, Luo S. | 07/14/2018 |
| Findings indicate that RFX1 functions downstream of STAT3 and phosphorylated STAT3 can inhibit RFX1 expression and suggest a unique role for RFX1 in Th17-related autoimmune diseases. | IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.
Zhao M, Tan Y, Peng Q, Huang C, Guo Y, Liang G, Zhu B, Huang Y, Liu A, Wang Z, Li M, Gao X, Wu R, Wu H, Long H, Lu Q., Free PMC Article | 03/17/2018 |
| Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR-124 regulation; identified the binding site through which RFX1 directly regulates ApoE, may explain the missing link between decreased miRNA-124 and ineffective Abeta uptaking during aging. | Regulatory factor X1 depresses ApoE-dependent Aβ uptake by miRNA-124 in microglial response to oxidative stress.
Feng CZ, Yin JB, Yang JJ, Cao L. | 11/11/2017 |
| induction of ciliogenesis increases the expression of RFX and dyslexia candidate genes | Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs.
Tammimies K, Bieder A, Lauter G, Sugiaman-Trapman D, Torchet R, Hokkanen ME, Burghoorn J, Castrén E, Kere J, Tapia-Páez I, Swoboda P., Free PMC Article | 09/9/2017 |
| Data show that transcription factor regulatory factor X 1 (RFX1) protein expression can be tightly regulated by polyubiquitination-mediated proteosomal degradation via STIP1 homology and U-box containing protein 1 (STUB1). | Transcription factor RFX1 is ubiquitinated by E3 ligase STUB1 in systemic lupus erythematosus.
Guo Y, Zhao M, Lu Q. | 04/1/2017 |
| therapeutic targets for childhood severe asthmatics identified thru DNA microarray | Identification of therapeutic targets for childhood severe asthmatics with DNA microarray.
Wu Y, Zhang JF, Xu T, Xu L, Qiao J, Liu F, Shan H, Jiang X. | 10/1/2016 |
| Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells. | RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.
Su JC, Tseng PH, Hsu CY, Tai WT, Huang JW, Ko CH, Lin MW, Liu CY, Chen KF, Shiau CW., Free PMC Article | 05/16/2015 |
| regulatory factor 1 directly regulates CD44 expression in glioblastoma | Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma.
Feng C, Zhang Y, Yin J, Li J, Abounader R, Zuo Z., Free PMC Article | 04/25/2015 |
| Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs. | Ciliogenic RFX transcription factors regulate FGF1 gene promoter.
Hsu YC, Kao CY, Chung YF, Chen MS, Chiu IM. | 11/3/2012 |
| RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription. | Regulatory factor X1-induced down-regulation of transforming growth factor β2 transcription in human neuroblastoma cells.
Feng C, Zuo Z., Free PMC Article | 09/15/2012 |
| NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis-regulatory elements. | NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression.
Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS., Free PMC Article | 08/11/2012 |
| in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter. | Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors.
Amin S, Kumar A, Nilchi L, Wright K, Kozlowski M. | 12/17/2011 |
| RFX1 recruits SUV39H1 to the promoter regions of the CD11a and CD70 genes in CD4(+) T cells, thereby regulating local H3K9 tri-methylation levels. | RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.
Zhao M, Wu X, Zhang Q, Luo S, Liang G, Su Y, Tan Y, Lu Q., Free PMC Article | 06/25/2011 |
| regulates autoimmunity via epigenetic modifications in T cells of systemic lupus erythematosus patients | Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.
Zhao M, Sun Y, Gao F, Wu X, Tang J, Yin H, Luo Y, Richardson B, Lu Q. | 11/6/2010 |
| We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transc | Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.
Purvis TL, Hearn T, Spalluto C, Knorz VJ, Hanley KP, Sanchez-Elsner T, Hanley NA, Wilson DI., Free PMC Article | 06/14/2010 |
| RFX1 may negatively regulate the self-renewal of GBM-SCs through modulating FGF-1B and FGF1 expression levels by binding the 18-bp cis-elements of the F1B promoter. | Regulation of FGF1 gene promoter through transcription factor RFX1.
Hsu YC, Liao WC, Kao CY, Chiu IM., Free PMC Article | 05/31/2010 |
| RFX and/or enhanceosome assembly plays a key role independent of transcriptional coactivator CIITA in protecting major histocompatibility class II antigen promoters against DNA methylation. | The transcription factor RFX protects MHC class II genes against epigenetic silencing by DNA methylation.
Seguín-Estévez Q, De Palma R, Krawczyk M, Leimgruber E, Villard J, Picard C, Tagliamacco A, Abbate G, Gorski J, Nocera A, Reith W. | 01/21/2010 |
| RFX1 specifically bind to promoter region and negatively regulate the transcription of the human PNRC gene. | [Transcriptional regulation of the human gene coding for proline-rich nuclear receptor coactivator (pnrc) by regulatory factor x (rfx1)].
Zhang Y, Chen B, Li YP, Lou GY, Chen M, Zhou DJ. | 01/21/2010 |
| RFX1 mediates the immediate early response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells. | RFX1 mediates the serum-induced immediate early response of Id2 gene expression.
Wang KR, Nemoto T, Yokota Y. | 01/21/2010 |