| RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias. | RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias.
Kanwal A, Pardo JV, Naz S., Free PMC Article | 11/5/2022 |
| Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis. | Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis.
Hao F, Wang N, Gui H, Zhang Y, Wu Z, Wang J., Free PMC Article | 10/29/2022 |
| The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS. | The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS.
Li C, Vides A, Kim D, Xue JY, Zhao Y, Lito P., Free PMC Article | 10/16/2021 |
| Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer. | Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer.
Li W, Si X, Yang J, Zhang J, Yu K, Cao Y. | 09/11/2021 |
| A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function. | A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.
Yazdani A, Yazdani A, Méndez Giráldez R, Aguilar D, Sartore L., Free PMC Article | 10/24/2020 |
| The present study revealed that miR1263p plays a role as a tumor suppressor in regulating TNBC cell activities by targeting RGS3. | MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3.
Hong Z, Hong C, Ma B, Wang Q, Zhang X, Li L, Wang C, Chen D. | 10/26/2019 |
| It has been reported that mitotic kinesin KIF20A interacts with RGS3 and plays a crucial role in controlling the division modes of neural progenitor cells during cortical neurogenesis. | KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.
Geng A, Qiu R, Murai K, Liu J, Wu X, Zhang H, Farhoodi H, Duong N, Jiang M, Yee JK, Tsark W, Lu Q., Free PMC Article | 12/22/2018 |
| Findings suggest that overexpressed RGS3 regulated by microRNA-126 through the post-transcriptional modulation is associated significantly with a poor prognosis of GC patients. | Regulator of G-protein signaling 3 targeted by miR-126 correlates with poor prognosis in gastric cancer patients.
Wang J, Zhou Y, Fei X, Chen X, Zhu Z. | 10/28/2017 |
| Our data provide a novel miR-25/RGS3 signal in the development of lung cancer. | Elevated microRNA-25 inhibits cell apoptosis in lung cancer by targeting RGS3.
Chen Z, Wu Y, Meng Q, Xia Z. | 10/22/2016 |
| cardiac overexpression of RGS3 inhibits maladaptive hypertrophy and fibrosis and improves cardiac function by blocking MEK-ERK1/2 signaling | Regulator of G protein signaling 3 protects against cardiac hypertrophy in mice.
Liu Y, Huang H, Zhang Y, Zhu XY, Zhang R, Guan LH, Tang Q, Jiang H, Huang C. | 11/8/2014 |
| ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected. | Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.
Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J., Free PMC Article | 03/22/2014 |
| PDZ-RGS3 can enhance signals generated by the Wnt canonical pathway and plays a pivotal role in epithelial mesenchymal transition | Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition.
Shi CS, Huang NN, Kehrl JH., Free PMC Article | 12/22/2012 |
| Results suggest that the 14-3-3 protein binding affects the structure of the Galpha interaction portion of RGS3 as well as sterically blocks the interaction between the RGS domain and the Galpha subunit of heterotrimeric G proteins. | Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function.
Rezabkova L, Man P, Novak P, Herman P, Vecer J, Obsilova V, Obsil T., Free PMC Article | 03/31/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| 14-3-3 protein binding induces structural changes in both the N-terminal part and the C-terminal RGS domain of phosphorylated RGS3 molecule | 14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3).
Rezabkova L, Boura E, Herman P, Vecer J, Bourova L, Sulc M, Svoboda P, Obsilova V, Obsil T. | 08/23/2010 |
| Regulator of G-protein signalling 3 (RGS3) showed a difference between follicular cells from follicles leading to a pregnancy or developmental failure. | Genomic assessment of follicular marker genes as pregnancy predictors for human IVF.
Hamel M, Dufort I, Robert C, Léveillé MC, Leader A, Sirard MA. | 03/22/2010 |
| in apoptosis-initiated cells, the ligand-dependent C5aR-mediated dual signal affects the fate of cells, either apoptosis execution or survival, through regulation of RGS3 gene expression and subsequent modulation of ERK signal. | Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase.
Nishiura H, Nonaka H, Revollo IS, Semba U, Li Y, Ota Y, Irie A, Harada K, Kehrl JH, Yamamoto T., Free PMC Article | 01/21/2010 |
| This study identifies a novel, noncanonical role of RGS3 in regulation of TGF-beta signaling through its interaction with Smads and interfering with Smad heteromerization. | Regulation of Smad-mediated gene transcription by RGS3.
Yau DM, Sethakorn N, Taurin S, Kregel S, Sandbo N, Camoretti-Mercado B, Sperling AI, Dulin NO., Free PMC Article | 01/21/2010 |
| mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. | Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.
Ooe A, Kato K, Noguchi S. | 01/21/2010 |
| Full-length RGS3, RGS3T, and the core domain of RGS3 were equally effective in antagonizing inhibition of Ca(V)2.3 through M(2)R. | Muscarinic modulation of Cav2.3 (R-type) calcium channels is antagonized by RGS3 and RGS3T.
Toro-Castillo C, Thapliyal A, Gonzalez-Ochoa H, Adams BA, Meza U. | 01/21/2010 |
| RFS3 promoted the conversion of more stable Ca2+ elevations into oscillatory signals. | Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor.
Tovey SC, Willars GB. | 01/21/2010 |
| C2PA is expressed in the cell nucleus and induces heat shock response element (HSE)-dependent gene transcription | C2PA is a nuclear protein implicated in the heat shock response.
Hirabayashi S, Ohno H, Iida J, Hata Y. | 01/21/2010 |
| RGS3L functions as a molecular switch, redirecting Gi-coupled receptors via Gbetagamma-dimers and PI3K from Rac1 to RhoA activation. | Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation.
Vogt A, Lutz S, Rümenapp U, Han L, Jakobs KH, Schmidt M, Wieland T. | 01/21/2010 |
| Data are consistent with the model wherein 14-3-3 serves as a scavenger of RGS3, regulating the amounts of RGS3 available for binding G-proteins. | RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain.
Niu J, Scheschonka A, Druey KM, Davis A, Reed E, Kolenko V, Bodnar R, Voyno-Yasenetskaya T, Du X, Kehrl J, Dulin NO., Free PMC Article | 01/21/2010 |