| Ectodysplasin A2 receptor-NF-kappaB-inducing kinase axis: a new player in muscle wasting to cancer cachexia. | Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia.
von Renesse J, Mirtschink P., Free PMC Article | 11/3/2023 |
| EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. | EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
Bilgic SN, Domaniku A, Toledo B, Agca S, Weber BZC, Arabaci DH, Ozornek Z, Lause P, Thissen JP, Loumaye A, Kir S. | 06/1/2023 |
| Tumor Suppressor Gene XEDAR Promotes Differentiation and Suppresses Proliferation and Migration of Gastric Cancer Cells Through Upregulating the RELA/LXRalpha Axis and Deactivating the Wnt/beta-Catenin Pathway. | Tumor Suppressor Gene XEDAR Promotes Differentiation and Suppresses Proliferation and Migration of Gastric Cancer Cells Through Upregulating the RELA/LXRα Axis and Deactivating the Wnt/β-Catenin Pathway.
Zhang X, Zhang D, Sun X, Li S, Sun Y, Zhai H., Free PMC Article | 12/11/2021 |
| Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor. | Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor.
Kwack MH, Jun MS, Sung YK, Kim JC, Kim MK. | 02/13/2021 |
| EDA2R mediates podocyte injury in high glucose milieu. | EDA2R mediates podocyte injury in high glucose milieu.
Lan X, Kumar V, Jha A, Aslam R, Wang H, Chen K, Yu Y, He W, Chen F, Luo H, Malhotra A, Singhal PC., Free PMC Article | 01/16/2021 |
| XEDAR inhibits the proliferation and induces apoptosis of gastric cancer cells by regulating JNK signaling pathway. | XEDAR inhibits the proliferation and induces apoptosis of gastric cancer cells by regulating JNK signaling pathway.
Yang L, Huang X, Wang W, Jiang T, Ding F., Free PMC Article | 09/26/2020 |
| Expression of EDA2R in human hair follicles.EDA-A2/EDA2R signaling could inhibit hair growth. | Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice.
Kwack MH, Kim JC, Kim MK. | 07/25/2020 |
| The upregulation of SPOCK2-encoded Testican2 proteoglycan and of ectodysplasin (EDA) protein was coupled with a down-regulation of EDA2 receptor (EDA2R). | Studies on sporadic non-syndromic thoracic aortic aneurysms: II. Alterations of extra-cellular matrix components and focal adhesion proteins.
Chiarini A, Onorati F, Marconi M, Pasquali A, Patuzzo C, Malashicheva A, Irtyega O, Faggian G, Pignatti PF, Trabetti E, Armato U, Dal Pra I. | 06/15/2019 |
| We found evidence for AR but not EDA2R as the candidate gene at the androgenetic alopecia risk locus on chromosome X. | Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia.
Chew EGY, Tan JHJ, Bahta AW, Ho BS, Liu X, Lim TC, Sia YY, Bigliardi PL, Heilmann S, Wan ACA, Nöthen MM, Philpott MP, Hillmer AM. | 07/22/2017 |
| EDA-A2 and its receptor XEDAR are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR system in these cells is involved in the induction of apoptosis via CASP3 activation. | X-linked ectodermal dysplasia receptor (XEDAR) gene silencing prevents caspase-3-mediated apoptosis in Sjögren's syndrome.
Sisto M, Lorusso L, Lisi S. | 02/18/2017 |
| XEDAR activates the non-canonical NF-kappaB pathway. | XEDAR activates the non-canonical NF-κB pathway.
Verhelst K, Gardam S, Borghi A, Kreike M, Carpentier I, Beyaert R. | 11/14/2015 |
| To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs. | A tale of two haplotypes: the EDA2R/AR Intergenic region is the most divergent genomic segment between Africans and East Asians in the human genome.
Casto AM, Henn BM, Kidd JM, Bustamante CD, Feldman MW. | 06/28/2014 |
| The results suggest that EDA2R confers susceptibility to early onset female pattern hair loss | Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss.
Redler S, Brockschmidt FF, Tazi-Ahnini R, Drichel D, Birch MP, Dobson K, Giehl KA, Herms S, Refke M, Kluck N, Kruse R, Lutz G, Wolff H, Böhm M, Becker T, Nöthen MM, Messenger AG, Betz RC. | 09/1/2012 |
| association in dental crowding in the Hong Kong Chinese population | Analysis of genetic polymorphisms in skeletal Class I crowding.
Ting TY, Wong RW, Rabie AB. | 09/3/2011 |
| A crucial role of the EDA-A2/ectodysplasin A2 (XEDAR) interaction is revealed in the p53-signaling pathway. | Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway.
Tanikawa C, Ri C, Kumar V, Nakamura Y, Matsuda K. | 01/29/2011 |
| because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R | Fine mapping of the human AR/EDA2R locus in androgenetic alopecia.
Brockschmidt FF, Hillmer AM, Eigelshoven S, Hanneken S, Heilmann S, Barth S, Herold C, Becker T, Kruse R, Nöthen MM. | 10/23/2010 |
| XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis. | XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway.
Tanikawa C, Furukawa Y, Yoshida N, Arakawa H, Nakamura Y, Matsuda K. | 01/21/2010 |
| androgen receptor/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness | Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness.
Hillmer AM, Freudenberg J, Myles S, Herms S, Tang K, Hughes DA, Brockschmidt FF, Ruan Y, Stoneking M, Nöthen MM., Free PMC Article | 01/21/2010 |
| The androgen receptor gene and EDA2R are significantly associated with androgenetic alopecia. | EDA2R is associated with androgenetic alopecia.
Prodi DA, Pirastu N, Maninchedda G, Sassu A, Picciau A, Palmas MA, Mossa A, Persico I, Adamo M, Angius A, Pirastu M, Prodi DA, Pirastu N, Maninchedda G, Sassu A, Picciau A, Palmas MA, Mossa A, Persico I, Adamo M, Angius A, Pirastu M. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesFGFR2 is associated with hair thickness in Asian populations.
Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Tsunoda T, Tokunaga K, Ohashi J. EDA2R is associated with androgenetic alopecia.
Prodi DA, Pirastu N, Maninchedda G, Sassu A, Picciau A, Palmas MA, Mossa A, Persico I, Adamo M, Angius A, Pirastu M, Prodi DA, Pirastu N, Maninchedda G, Sassu A, Picciau A, Palmas MA, Mossa A, Persico I, Adamo M, Angius A, Pirastu M. | 04/23/2008 |
| XEDAR belongs to a novel class of death receptors that lack a discernible death domain but are capable of activating apoptosis in a caspase 8- and FADD-dependent fashion | Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism.
Sinha SK, Chaudhary PM. | 01/21/2010 |
| isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR | Repertoire of mouse ectodysplasin-A (EDA-A) isoforms.
Hashimoto T, Cui CY, Schlessinger D. | 01/21/2010 |
| Results establish a major role of TRAF3 and -6 in X-linked ectodermal dysplasia receptor (XEDAR) signaling and in the process of ectodermal differentiation. | Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.
Sinha SK, Zachariah S, Quiñones HI, Shindo M, Chaudhary PM. | 01/21/2010 |