| Gene expression pattern of Kisspeptin and RFamide-related peptide (Rfrp) in the male Damaraland mole-rat hypothalamus. | Gene expression pattern of Kisspeptin and RFamide-related peptide (Rfrp) in the male Damaraland mole-rat hypothalamus.
Voigt C, Bennett NC. | 04/2/2022 |
| Chronic stress has long-term effects on pregnancy success, even post-stressor, that are mediated by RFRP3.[RFRP3] | Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption.
Geraghty AC, Muroy SE, Zhao S, Bentley GE, Kriegsfeld LJ, Kaufer D., Free PMC Article | 09/22/2021 |
| RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis. | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis.
Huo K, Li X, Hu W, Song X, Zhang D, Zhang X, Chen X, Yuan J, Zuo J, Wang X., Free PMC Article | 04/3/2021 |
| role in modulating ovarian physiology in response to sympathetic stress | Role of RFRP-3 in the development of cold stress-induced polycystic ovary phenotype in rats.
Squicciarini V, Riquelme R, Wilsterman K, Bentley GE, Lara HE. | 09/14/2019 |
| study concluded that RFamide-related peptide- (3RFRP-3) plays a regulatory role in male rat reproduction | Effect of RFRP-3, the mammalian ortholog of GnIH, on the epididymis of male rats.
Wang X, Guo G, Zhang X, Li M, Xiao K, Hu C, Li X. | 11/24/2018 |
| Rfrp (GnIH)-expressing neurons serve as potential upstream mediators of stress-induced effects through Gpr147 (GnIH-R)-dependent mechanisms. | Glucocorticoid receptor-mediated regulation of Rfrp (GnIH) and Gpr147 (GnIH-R) synthesis in immortalized hypothalamic neurons.
Gojska NM, Belsham DD. | 11/8/2014 |
| Hypothalamic expression of Rfrp and Rfrp1r receptor in rats peaks during the pubertal period in males (postnatal day (PND)-35 to PND-42) but not in females | Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.
León S, García-Galiano D, Ruiz-Pino F, Barroso A, Manfredi-Lozano M, Romero-Ruiz A, Roa J, Vázquez MJ, Gaytan F, Blomenrohr M, van Duin M, Pinilla L, Tena-Sempere M. | 09/20/2014 |
| Both acute and chronic immobilization stress lead to an up-regulation of RFRP expression in the dorsomedial hypothalamus (DMH) of adult male rats. | Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats.
Kirby ED, Geraghty AC, Ubuka T, Bentley GE, Kaufer D., Free PMC Article | 02/12/2013 |
| The hypothalamic RFRP system changes during development. Ovarian sex steroid estradiol-17beta (E2) may stimulate mRNA expression of RFRP in the prepubertal period when the basal E2 concentration is low. | Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus.
Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Osugi T, Gereltsetseg G, Yoshida S, Irahara M, Tsutsui K. | 09/8/2012 |
| RFRP-3 inhibits secretion of LH and FSH inmammals. | Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies.
Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, van Noort PI, Tena-Sempere M. | 07/19/2010 |
| Developmental and steroidogenic effects on the gene expression of RFamide related peptides and their receptor in the rat brain and pituitary gland. | Developmental and steroidogenic effects on the gene expression of RFamide related peptides and their receptor in the rat brain and pituitary gland.
Quennell JH, Rizwan MZ, Relf HL, Anderson GM. | 06/28/2010 |
| Results describe the distribution of RFRP neurons in the rat brain, and compare it to those of melanin-concentrating hormone neurons and hypocretin neurons. | Distribution and genesis of the RFRP-producing neurons in the rat brain: comparison with melanin-concentrating hormone- and hypocretin-containing neurons.
Legagneux K, Bernard-Franchi G, Poncet F, La Roche A, Colard C, Fellmann D, Pralong F, Risold PY. | 01/21/2010 |
| RFRP-3 is not a hypophysiotropic neuroendocrine hormone in rats. | Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat.
Rizwan MZ, Porteous R, Herbison AE, Anderson GM. | 01/21/2010 |
| Endogenous rat RFRP-3 does not affect the timing of puberty in male rats but may be associated with peripubertal rise in growth hormone secretion. | Rat RFRP-3 alters hypothalamic GHRH expression and growth hormone secretion but does not affect KiSS-1 gene expression or the onset of puberty in male rats.
Johnson MA, Fraley GS. | 01/21/2010 |
| These results indicate that RFRP-3 has similar effects on LH as observed with GnIH in avian species; in the rat RFRP-3 has additional roles in regulating feeding and growth. | Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat.
Johnson MA, Tsutsui K, Fraley GS., Free PMC Article | 01/21/2010 |