| MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2alpha-CYR61 axis. | MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.
Yan F, Wang Q, Xia M, Ru Y, Hu W, Yan G, Xiong X, Zhang M, Wang J, Li Q, Zhang B, Wang H, Lin W, Wu G, Li X., Free PMC Article | 09/3/2022 |
| MIIP inhibits malignant progression of hepatocellular carcinoma through regulating AKT. | MIIP inhibits malignant progression of hepatocellular carcinoma through regulating AKT.
Fang J, Chen YL, Yao HB, Peng SS, Yang P, Ding ZY. | 03/20/2021 |
| MIIP suppresses oncogenic AKT-mTOR signaling in prostate cancer by facilitating PP1-mediated AKT dephosphorylation. | MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling.
Yan G, Ru Y, Yan F, Xiong X, Hu W, Pan T, Sun J, Zhang C, Wang Q, Li X., Free PMC Article | 04/11/2020 |
| MIIP was significantly decreased and IGFBP2 was significantly increased in breast cancer tissues versus para cancerous. | Upregulation of MIIP regulates human breast cancer proliferation, invasion and migration by mediated by IGFBP2.
Du Y, Wang P. | 01/18/2020 |
| Dysregulated miR-646 and MIIP expression was correlated with advanced tumor stage, lymphatic invasion, metastasis and shorter overall survival in Pancreatic cancer patients. | MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer.
Niu Y, Jin Y, Deng SC, Deng SJ, Zhu S, Liu Y, Li X, He C, Liu ML, Zeng Z, Chen HY, Zhong JX, Ye Z, Wang CY, Zhao G. | 03/30/2019 |
| Data show that protein kinase C epsilon (PKCepsilon) phosphorylates migration and invasion inhibitory protein (MIIP) at Ser303 and promotes its binding to RelA/p65, facilitating colorectal cancer metastasis. | PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.
Chen T, Li J, Xu M, Zhao Q, Hou Y, Yao L, Zhong Y, Chou PC, Zhang W, Zhou P, Jiang Y., Free PMC Article | 03/10/2018 |
| MIIP may function as a tumor suppressor gene for endometrial carcinoma. MIIP attenuates Rac1 signaling through a protein interaction network, and loss of this regulator may contribute to EC metastasis. | MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis.
Wang Y, Hu L, Ji P, Teng F, Tian W, Liu Y, Cogdell D, Liu J, Sood AK, Broaddus R, Xue F, Zhang W., Free PMC Article | 12/9/2017 |
| MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. | MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.
Sun Y, Ji P, Chen T, Zhou X, Yang D, Guo Y, Liu Y, Hu L, Xia D, Liu Y, Multani AS, Shmulevich I, Kucherlapati R, Kopetz S, Sood AK, Hamilton SR, Sun B, Zhang W., Free PMC Article | 05/13/2017 |
| MIIP expression in esophageal squamous-cell carcinoma tissues was increased significantly in comparison with the paired paracancerous normal epithelia and was associated with cell differentiation. Patients with low MIIP expression had improved overall and disease-free survival. MIIP expression was an independent prognostic factor in ESCC OS and DFS. | MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas.
Wen J, Liu QW, Luo KJ, Ling YH, Xie XY, Yang H, Hu Y, Fu JH. | 02/18/2017 |
| MIIP attenuates mitotic transition and increases mitotic catastrophe, thereby inhibiting glioma development and progression. | Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP.
Ji P, Smith SM, Wang Y, Jiang R, Song SW, Li B, Sawaya R, Bruner JM, Kuang J, Yu H, Fuller GN, Zhang W. | 07/5/2010 |
| Data show a novel mechanism by which IIp45 inhibits cell motility through inhibition of HDAC6. | IIp45 inhibits cell migration through inhibition of HDAC6.
Wu Y, Song SW, Sun J, Bruner JM, Fuller GN, Zhang W., Free PMC Article | 04/12/2010 |
| Results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis. | Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer.
Song F, Ji P, Zheng H, Song F, Wang Y, Hao X, Wei Q, Zhang W, Chen K. | 03/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q., Free PMC Article | 12/2/2009 |
| IIp45 gene is inactivated by a tumor-specific alternative splicing that generates an aberrant and unstable IIp45 isoform in infiltrative gliomas. | Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas.
Song SW, Fuller GN, Zheng H, Zhang W. | 01/21/2010 |
| identified a gene, invasion inhibitory protein 45 (IIp45), whose protein product bound to IGFBP-2 through the thyroglobulin-RGD region of the C terminus of IGFBP-2 | IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion.
Song SW, Fuller GN, Khan A, Kong S, Shen W, Taylor E, Ramdas L, Lang FF, Zhang W., Free PMC Article | 01/21/2010 |