| Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer. | Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer.
Li X, Chang E, Cui J, Zhao H, Hu C, O'Dea KP, Tirlapur N, Balboni G, Zhang J, Ying L, Ma D., Free PMC Article | 05/15/2023 |
| Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction. | Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction.
Schirinzi T, Lattanzi R, Maftei D, Grillo P, Zenuni H, Boffa L, Albanese M, Simonetta C, Bovenzi R, Maurizi R, Loccisano L, Vincenzi M, Greco A, Di Girolamo S, Mercuri NB, Passali FM, Severini C., Free PMC Article | 02/4/2023 |
| Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2. | Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2.
Yin TC, Mittal A, Buscaglia P, Li W, Sebag JA., Free PMC Article | 02/4/2023 |
| Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease. | Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease.
Schirinzi T, Maftei D, Passali FM, Grillo P, Zenuni H, Mascioli D, Maurizi R, Loccisano L, Vincenzi M, Rinaldi AM, Ralli M, Di Girolamo S, Stefani A, Lattanzi R, Severini C, Mercuri NB. | 01/21/2023 |
| PROK2, HRNR, and FIG4 as potential genetic biomarkers of high bleeding propensity in East Asian patients with acute coronary syndrome using ticagrelor. | PROK2, HRNR, and FIG4 as potential genetic biomarkers of high bleeding propensity in East Asian patients with acute coronary syndrome using ticagrelor.
Xiang Q, Wang Z, Mu G, Xie Q, Liu Z, Zhou S, Zhang H, Wang Z, Hu K, Song H, Yuan D, Xia Q, Huang Y, Cui Y. | 12/24/2022 |
| Prokineticin 2 in cancer-related inflammation. | Prokineticin 2 in cancer-related inflammation.
Lattanzi R, Severini C, Miele R. | 09/10/2022 |
| Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis. | Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.
Noda K, Dufner B, Ito H, Yoshida K, Balboni G, Straub RH., Free PMC Article | 12/18/2021 |
| The novel function of miR-3195 for mutant PROK2 (c.223-4C>A) degradation. | The novel function of miR-3195 for mutant PROK2 (c.223-4C>A) degradation.
Zhou S, Li P. | 09/4/2021 |
| Pleiotropic effects of prokineticin 2 in the control of energy metabolism. | Pleiotropic effects of prokineticin 2 in the control of energy metabolism.
Magnan C, Migrenne-Li S. | 08/7/2021 |
| Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury. | Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.
Bao Z, Liu Y, Chen B, Miao Z, Tu Y, Li C, Chao H, Ye Y, Xu X, Sun G, Zhao P, Liu N, Liu Y, Wang X, Lam SM, Kagan VE, Bayır H, Ji J., Free PMC Article | 07/24/2021 |
| Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes. | Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes.
Ma M, Li H, Wu J, Zhang Y, Shen H, Li X, Wang Z, Chen G. | 06/5/2021 |
| Silencing PROK2 Inhibits Invasion of Human Cervical Cancer Cells by Targeting MMP15 Expression. | Silencing PROK2 Inhibits Invasion of Human Cervical Cancer Cells by Targeting MMP15 Expression.
Wu MH, Wu PR, Hsieh YH, Lin CL, Liu CJ, Ying TH., Free PMC Article | 03/28/2021 |
| We demonstrated a significant upregulation of PROK2 levels in brain tissues of Abeta1-42 i.c.v. injected rats, transgenic AD mice (Tg2576), and in the hippocampus of AD patients. Additionally, through a pilot study, an approximate twofold increase of PROK2 levels has been proved in the serum of AD patients, compared to the control subjects, identifying a potential blood-based biomarker of the disease. | Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology.
Lattanzi R, Maftei D, Petrella C, Pieri M, Sancesario G, Schirinzi T, Bernardini S, Barbato C, Ralli M, Greco A, Possenti R, Sancesario G, Severini C., Free PMC Article | 07/11/2020 |
| In PK2-mediated anti-adipogenic signaling, KDM6A stabilizes and increases cytoplasmic beta-catenin levels to repress peroxisome proliferator-activated receptor-gamma expression and activity. Findings offer additional molecular targets to manipulate hEPDCs-involved tissue repair/regeneration in cardiometabolic and ischemic heart diseases. | A Prokineticin-Driven Epigenetic Switch Regulates Human Epicardial Cell Stemness and Fate.
Qureshi R, Kindo M, Boulberdaa M, von Hunolstein JJ, Steenman M, Nebigil CG. | 11/30/2019 |
| infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively. Finally, the administration of 5-FU after the resection of the primary tumor failed to augment lung metastasis in the mice receiving Prokr1-deleted 4T1 cells. | Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N. | 07/27/2019 |
| Results reveal that PK2 regulates a novel neuron-astrocyte signaling mechanism by promoting an alternative A2 protective phenotype in astrocytes. PK2-induced astrocyte reactivity leads to an increase in antioxidant and anti-inflammatory proteins while increasing glutamate uptake, along with decreased inflammatory factors. | Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes.
Neal M, Luo J, Harischandra DS, Gordon R, Sarkar S, Jin H, Anantharam V, Désaubry L, Kanthasamy A, Kanthasamy A., Free PMC Article | 03/23/2019 |
| The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target. | Prokineticin 2 Plays a Pivotal Role in Psoriasis.
He X, Shen C, Lu Q, Li J, Wei Y, He L, Bai R, Zheng J, Luan N, Zhang Z, Rong M, Lai R., Free PMC Article | 02/18/2017 |
| Prokineticin-2 is correlated with various cardiometabolic risk factors. | Prokineticin-2 is associated with metabolic syndrome in a middle-aged and elderly Chinese population.
Wang Y, Guo X, Ma H, Lu L, Zhang R., Free PMC Article | 10/22/2016 |
| Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW] | Prokineticins in central and peripheral control of human reproduction.
Traboulsi W, Brouillet S, Sergent F, Boufettal H, Samouh N, Aboussaouira T, Hoffmann P, Feige JJ, Benharouga M, Alfaidy N. | 09/10/2016 |
| Suggest PROK2 as an angiogenic growth factor in colorectal cancer. | Prokineticin 2 (PROK2) is an important factor for angiogenesis in colorectal cancer.
Kurebayashi H, Goi T, Shimada M, Tagai N, Naruse T, Nakazawa T, Kimura Y, Hirono Y, Yamaguchi A., Free PMC Article | 07/30/2016 |
| study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance | Triallelic digenic mutation in the prokineticin 2 and GNRH receptor genes in two brothers with normosmic congenital hypogonadotropic hypogonadism.
Méndez JP, Zenteno JC, Coronel A, Soriano-Ursúa MA, Valencia-Villalvazo EY, Soderlund D, Coral-Vázquez RM, Canto P. | 06/11/2016 |
| PROK2 significantly increased in human fetal ovary across gestation. | Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.
Eddie SL, Childs AJ, Kinnell HL, Brown P, Jabbour HN, Anderson RA. | 11/28/2015 |
| EG-VEGF, BV8, and PROKR2 gene expression is approximately five, four, and two times higher in cystic fibrosis lungs compared with controls. | EG-VEGF, BV8, and their receptor expression in human bronchi and their modification in cystic fibrosis: Impact of CFTR mutation (delF508).
Chauvet S, Traboulsi W, Thevenon L, Kouadri A, Feige JJ, Camara B, Alfaidy N, Benharouga M. | 10/17/2015 |
| No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes | Multiplex ligation dependent probe amplification analysis of KAL1, GNRH1, GNRHR, PROK2 and PROKR2 in male patients with idiopathic hypogonadotropic hypogonadism.
Basaran Y, Bolu E, Unal HU, Sagkan RI, Taslipinar A, Ozgurtas T, Musabak U. | 09/26/2015 |
| PROK2 signaling in humans is not required for central circadian pacemaker function. | Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2.
Balasubramanian R, Cohen DA, Klerman EB, Pignatelli D, Hall JE, Dwyer AA, Czeisler CA, Pitteloud N, Crowley WF., Free PMC Article | 07/19/2014 |