| Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability. | Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability.
Ordoñez-Razo RM, Gutierrez-López Y, Araujo-Solis MA, Benitez-King G, Ramírez-Sánchez I, Galicia G., Free PMC Article | 05/13/2024 |
| SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2. | SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2.
Jiang Y, Tang Y. | 02/2/2024 |
| Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding. | Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding.
Miyaguchi M, Nakanishi Y, Maturana AD, Mizutani K, Niimi T. | 10/1/2022 |
| An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations. | An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.
Quiat D, Kim SW, Zhang Q, Morton SU, Pereira AC, DePalma SR, Willcox JAL, McDonough B, DeLaughter DM, Gorham JM, Curran JJ, Tumblin M, Nicolau Y, Artunduaga MA, Quintanilla-Dieck L, Osorno G, Serrano L, Hamdan U, Eavey RD, Seidman CE, Seidman JG., Free PMC Article | 05/28/2022 |
| ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma. | ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.
Ding C, Li Y, Wang S, Xing C, Chen L, Zhang H, Wang Y, Dai M. | 08/21/2021 |
| Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation. | Investigation of DNA variants specific to ROBO2 Isoform 'a' in Irish vesicoureteric reflux patients reveals marked CpG island variation.
Darlow JM, Dobson MG, Green AJ, Puri P, Barton DE., Free PMC Article | 11/21/2020 |
| The gene ROBO2 was decreased in patients with COPD and this decrease was significantly negatively correlated with the disease stages of COPD | Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis.
Lin YZ, Zhong XN, Chen X, Liang Y, Zhang H, Zhu DL., Free PMC Article | 04/18/2020 |
| results suggest that Robo2 functions as a receptor for NELL1/2, particularly under circumstances where Robo2 undergoes proteolytic digestion | Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2.
Yamamoto N, Kashiwagi M, Ishihara M, Kojima T, Maturana AD, Kuroda S, Niimi T., Free PMC Article | 12/14/2019 |
| determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4 | Robo Ig4 Is a Dimerization Domain.
Yom-Tov G, Barak R, Matalon O, Barda-Saad M, Guez-Haddad J, Opatowsky Y. | 12/2/2017 |
| human placental multipotent mesenchymal stromal cell express Slit2 and both Robo1 and Robo4 are present in human umbilical vein endothelial cells. | Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling.
Chen CY, Tsai CH, Chen CY, Wu YH, Chen CP., Free PMC Article | 08/5/2017 |
| ROBO2 variants were not found to be associated with nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia, providing further evidence for genetic heterogeneity | ROBO2 gene variants in children with primary nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia.
Mitsioni AG, Siomou E, Bouba I, Petridi S, Siamopoulou A, Georgiou I. | 05/27/2017 |
| ROBO2 and RASSF2A gene methylations may be related to gastric tumorigenesis, and ROBO2 gene methylation is associated with sporadic gastric cancer. | Correlations between gastric cancer family history and ROBO2 and RASSF2A gene methylations.
Chang ZW, Dong L, Qin YR, Song M, Guo HY, Zhu QL. | 02/18/2017 |
| Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer | Function of Slit/Robo signaling in breast cancer.
Gu F, Ma Y, Zhang J, Qin F, Fu L. | 09/24/2016 |
| ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired. | Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes.
Xu F, Wu LY, Chang CK, He Q, Zhang Z, Liu L, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X., Free PMC Article | 05/28/2016 |
| Common variation near ROBO2 is associated with expressive vocabulary in infancy. | Common variation near ROBO2 is associated with expressive vocabulary in infancy.
St Pourcain B, Cents RA, Whitehouse AJ, Haworth CM, Davis OS, O'Reilly PF, Roulstone S, Wren Y, Ang QW, Velders FP, Evans DM, Kemp JP, Warrington NM, Miller L, Timpson NJ, Ring SM, Verhulst FC, Hofman A, Rivadeneira F, Meaburn EL, Price TS, Dale PS, Pillas D, Yliherva A, Rodriguez A, Golding J, Jaddoe VW, Jarvelin MR, Plomin R, Pennell CE, Tiemeier H, Davey Smith G., Free PMC Article | 10/31/2015 |
| Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract | Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.
Hwang DY, Kohl S, Fan X, Vivante A, Chan S, Dworschak GC, Schulz J, van Eerde AM, Hilger AC, Gee HY, Pennimpede T, Herrmann BG, van de Hoek G, Renkema KY, Schell C, Huber TB, Reutter HM, Soliman NA, Stajic N, Bogdanovic R, Kehinde EO, Lifton RP, Tasic V, Lu W, Hildebrandt F., Free PMC Article | 09/26/2015 |
| Down-regulation of ROBO2 expression is associated with prostate cancers. | Down-regulation of ROBO2 expression in prostate cancers.
Choi YJ, Yoo NJ, Lee SH., Free PMC Article | 02/28/2015 |
| Frameshift mutations of ROBO1 and ROBO2 genes and alteration of ROBO2 expression in gastric and colorectal cancers suggest that both genes might play roles in the pathogenesis of both cancers. | Frameshift mutations of axon guidance genes ROBO1 and ROBO2 in gastric and colorectal cancers with microsatellite instability.
Je EM, Gwak M, Oh H, Choi MR, Choi YJ, Lee SH, Yoo NJ. | 08/9/2014 |
| The finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy. | Replication of a ROBO2 polymorphism associated with conduct problems but not psychopathic tendencies in children.
Dadds MR, Moul C, Cauchi A, Hawes DJ, Brennan J. | 06/14/2014 |
| Results not completely rule out that some ROBO2 variants may be the sole cause of vesicoureteric reflux, but it is clear from the overall frequency that most of them cannot be. | Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux.
Dobson MG, Darlow JM, Hunziker M, Green AJ, Barton DE, Puri P. | 03/15/2014 |
| data suggests the importance of abrogation of SLIT2-ROBO1 and SLIT2-ROBO2 interactions in the initiation and progression of CACX and also for early diagnosis and prognosis of the disease | Inactivation of SLIT2-ROBO1/2 pathway in premalignant lesions of uterine cervix: clinical and prognostic significances.
Mitra S, Mazumder-Indra D, Mondal RK, Basu PS, Roy A, Roychoudhury S, Panda CK., Free PMC Article | 12/22/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| gene variants in ROBO2 are rare causes of VUR in humans. Our results provide further evidence for the genetic heterogeneity of this disorder | Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux.
Zu S, Bartik Z, Zhao S, Sillen U, Nordenskjöld A. | 01/21/2010 |
| mRNA expression of ROBO2 in lymphocytes was significantly reduced in the autistic group | Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.
Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N. | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesIn search of genes associated with risk for psychopathic tendencies in children: a two-stage genome-wide association study of pooled DNA.
Viding E, Hanscombe KB, Curtis CJ, Davis OS, Meaburn EL, Plomin R. Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
Potkin SG, Turner JA, Guffanti G, Lakatos A, Fallon JH, Nguyen DD, Mathalon D, Ford J, Lauriello J, Macciardi F, FBIRN. | 12/3/2008 |