| HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling. | HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling.
Pai VP, Levin M. | 11/26/2022 |
| Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). | Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).
Lin W, Qin J, Ni G, Li Y, Xie H, Yu J, Li H, Sui L, Guo Q, Fang Z, Zhou L. | 11/27/2021 |
| Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study. | Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study.
Thomas M, Ranjith G, Radhakrishnan A, Arun Anirudhan V. | 09/19/2020 |
| overexpression of TBX3 and HCN2 could reprogram human-induced pluripotent stem cells-derived cardiomyocytes into pacemaker-like cells | HCN2 and TBX3 Reprogram Human-Induced Pluripotent Stem Cells-Derived Cardiomyocytes into Pacemaker-Like Cells.
Zhao H, Wang F, Tang Y, Wang X, Wang T, Zhao Q, Huang C. | 02/22/2020 |
| No significant association was found between HCN1/HCN2 alleles, genotypes or haplotypes, and drug resistance in patients, however, it was suggested that HCN2 rs3752158 is involved in the susceptibility to juvenile myoclonic epilepsy. | Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies.
Wu SZ, Ye H, Yang XG, Lu ZL, Qu Q, Qu J. | 05/25/2019 |
| Data suggest that HCN2 variants can confer susceptibility to Genetic generalized epilepsy via a gain-of-function mechanism. | Gain-of-function HCN2 variants in genetic epilepsy.
Li M, Maljevic S, Phillips AM, Petrovski S, Hildebrand MS, Burgess R, Mount T, Zara F, Striano P, Schubert J, Thiele H, Nürnberg P, Wong M, Weisenberg JL, Thio LL, Lerche H, Scheffer IE, Berkovic SF, Petrou S, Reid CA. | 01/12/2019 |
| beta2-adrenoceptors alone strongly enhanced the activity of HCN2 channels, and co-expression of odorant receptors further diversified the HCN2 channel activity. | Dual expression of constitutively active Gα(s)-protein-coupled receptors differentially establishes the resting activity of the cAMP-gated HCN2 channel in a single compartment.
Nakashima N, Nakashima K, Nakayama T, Takaku A, Kanamori R. | 11/18/2017 |
| TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels. | Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b.
Bankston JR, DeBerg HA, Stoll S, Zagotta WN., Free PMC Article | 11/4/2017 |
| HCN2 has a role in maturation and processing of the amyloid precursor protein | Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2).
Frykman S, Inoue M, Ikeda A, Teranishi Y, Kihara T, Lundgren JL, Yamamoto NG, Bogdanovic N, Winblad B, Schedin-Weiss S, Tjernberg LO. | 06/10/2017 |
| promoter methylation status does not appear to be a major determinant of HCN2 expression in normal and adenoid cystic carcinoma ( ACC )tissues. HCN2 hypomethylation is a biomarker of ACC and may play an important role in the carcinogenesis of ACC. | Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening.
Ling S, Rettig EM, Tan M, Chang X, Wang Z, Brait M, Bishop JA, Fertig EJ, Considine M, Wick MJ, Ha PK., Free PMC Article | 04/1/2017 |
| Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm. | Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation.
Li YD, Hong YF, Yusufuaji Y, Tang BP, Zhou XH, Xu GJ, Li JX, Sun L, Zhang JH, Xin Q, Xiong J, Ji YT, Zhang Y., Free PMC Article | 05/7/2016 |
| Data show that Rab8b-interacting protein TRIP8b does not compete with cyclic AMP for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2). | Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Saponaro A, Pauleta SR, Cantini F, Matzapetakis M, Hammann C, Donadoni C, Hu L, Thiel G, Banci L, Santoro B, Moroni A., Free PMC Article | 05/2/2015 |
| N-glycosylation is not required for HCN2 channels to function. | Effects of N-glycosylation on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Li M, Tonggu L, Tang L, Wang L. | 04/18/2015 |
| Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels. | HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation.
Schnorr S, Eberhardt M, Kistner K, Rajab H, Käer J, Hess A, Reeh P, Ludwig A, Herrmann S. | 12/20/2014 |
| Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. | Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.
Nakamura Y, Shi X, Numata T, Mori Y, Inoue R, Lossin C, Baram TZ, Hirose S., Free PMC Article | 09/13/2014 |
| HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri-implantitis. | Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) polymorphism is associated with chronic inflammatory periodontitis. A cross-sectional study.
Ebadian AR, Kadkhodazadeh M, Soltanian N, Amid R. | 06/28/2014 |
| LBB-injected HCN2/SkM1 potentially provides a more clinically suitable biological pacemaker strategy than other reported constructs. This superiority is attributable to the more negative AP threshold and injection into the LBB | HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates.
Boink GJ, Duan L, Nearing BD, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Bobkov E, Kryukova Y, Ozgen N, Danilo P Jr, Cohen IS, Verrier RL, Robinson RB, Rosen MR., Free PMC Article | 05/11/2013 |
| HCN2 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures. | Hyperpolarization-activated cation current contributes to spontaneous network activity in developing neocortical cultures.
Klueva J, Lima AD, Meis S, Voigt T, Munsch T. | 09/22/2012 |
| This is the first evidence in humans for a single-point, homozygous loss-of-function mutation in HCN2 potentially associated with generalized epilepsy with recessive inheritance. | Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.
DiFrancesco JC, Barbuti A, Milanesi R, Coco S, Bucchi A, Bottelli G, Ferrarese C, Franceschetti S, Terragni B, Baruscotti M, DiFrancesco D., Free PMC Article | 02/11/2012 |
| Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4. | Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.
Tu E, Waterhouse L, Duflou J, Bagnall RD, Semsarian C., Free PMC Article | 02/4/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation | Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha.
Huang J, Huang A, Zhang Q, Lin YC, Yu HG., Free PMC Article | 01/21/2010 |
| Several functional variants were identified including the amino acid substitution R527Q in HCN2 exon 5. HCN2 channels containing the R527Q variant demonstrated a trend towards a decreased slope of the conductance-voltage relation. | Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.
Tang B, Sander T, Craven KB, Hempelmann A, Escayg A, Tang B, Sander T, Craven KB, Hempelmann A, Escayg A., Free PMC Articles: PMC2709210, PMC2709210 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesAugmented currents of an HCN2 variant in patients with febrile seizure syndromes.
Dibbens LM, Reid CA, Hodgson B, Thomas EA, Phillips AM, Gazina E, Cromer BA, Clarke AL, Baram TZ, Scheffer IE, Berkovic SF, Petrou S. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy.
Tang B, Sander T, Craven KB, Hempelmann A, Escayg A, Tang B, Sander T, Craven KB, Hempelmann A, Escayg A. [Association between familial febrile convulsions and HCN2 gene].
Ma YN, Chen ZY, Zou LP, Zhang Y, Niu SL, Xu YF, Pei P, Bu DF, Qi Y. | 03/13/2008 |
| HCN1 and HCN2 expression were measured using in situ hybridization and immunocytochemistry in hippocampi; the expression of HCN isoforms is dynamically regulated in human as well as in experimental hippocampal epilepsy | Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.
Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ., Free PMC Article | 01/21/2010 |