| Phosphorylation of the conserved C-terminal domain of ribosomal P-proteins impairs the mode of interaction with plant toxins. | Phosphorylation of the conserved C-terminal domain of ribosomal P-proteins impairs the mode of interaction with plant toxins.
Horbowicz-Drożdżal P, Kamel K, Kmiecik S, Borkiewicz L, Tumer NE, Shaw PC, Tchórzewski M, Grela P. | 10/2/2021 |
| A three-gene signature and clinical outcome in pediatric acute myeloid leukemia. | A three-gene signature and clinical outcome in pediatric acute myeloid leukemia.
Cai Z, Wu Y, Zhang F, Wu H. | 09/18/2021 |
| Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins. | Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins.
Campos RK, Wijeratne HRS, Shah P, Garcia-Blanco MA, Bradrick SS., Free PMC Article | 11/21/2020 |
| Collectively, the present results suggest that PhoRpp21 binds the loop between P11 and P12 helices through overall positively charged clusters on the surface of the complex and serves as a scaffold for PhoRpp29 to optimize structural conformation of its N-terminal helix (alpha2) in PhoRpp21, as well as C-terminal residues in PhoRpp29, for RNase P activity. | Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis.
Jiang D, Izumi K, Ueda T, Oshima K, Nakashima T, Kimura M. | 06/3/2017 |
| absence of RPLP0, RPLP1, or RPLP2 resulted in reactive oxygen species (ROS) accumulation and MAPK1/ERK2 signaling pathway activation. | Disruption of the ribosomal P complex leads to stress-induced autophagy.
Artero-Castro A, Perez-Alea M, Feliciano A, Leal JA, Genestar M, Castellvi J, Peg V, Ramón Y Cajal S, Lleonart ME., Free PMC Article | 06/28/2016 |
| Results show that the conserved C-terminal segment of P2 from three different eukaryotic species- Human, Plasmodium falciparum and Toxoplasma gondii is intrinsically disordered. | The C-terminal domain of eukaryotic acidic ribosomal P2 proteins is intrinsically disordered with conserved structural propensities.
Mishra P, Rajagopal S, Sharma S, Hosur RV. | 11/7/2015 |
| Evaluated autoantibodies against native ribosomal P complex and recombinant ribosomal P proteins (anti-Rib-P0, anti-Rib-P1, anti-Rib-P2) for prevalence, diagnostic relevance&clinical associations in a Chinese cohort with systemic lupus erythematosus. | Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.
Li J, Shen Y, He J, Jia R, Wang X, Chen X, Wang D, Han L, Zhu L, Chi X, Saschenbrecker S, Dähnrich C, Stöcker W, Schlumberger W, Li ZG., Free PMC Article | 11/23/2013 |
| Data show that ricin A-chain (RTA) interacts directly with recombinant P1-P2 dimer, indicating the importance of P1 and P2 in enabling RTA to bind and depurinate ribosomes. | The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.
May KL, Li XP, Martínez-Azorín F, Ballesta JP, Grela P, Tchórzewski M, Tumer NE., Free PMC Article | 01/12/2013 |
| relevance of the observed cross-reactive IgE autoantibodies against P2 proteins in systemic lupus eryth remains to be elucidated | Auto-reactive IgE responses to acidic ribosomal P(2) protein in systemic lupus erythematosus.
Rhyner C, Daigle I, Crameri R. | 12/10/2011 |
| P proteins are up-regulated in a considerable number of patients with the most common types of cancer. | Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors.
Artero-Castro A, Castellvi J, García A, Hernández J, Ramón y Cajal S, Lleonart ME. | 02/26/2011 |
| the eukaryotic stalk protein P2 forms a symmetric homodimer in solution, and is structurally distinct from the bacterial counterpart L12 homodimer. | Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk.
Lee KM, Yu CW, Chan DS, Chiu TY, Zhu G, Sze KH, Shaw PC, Wong KB., Free PMC Article | 10/4/2010 |
| These results support the hypothesis that at least some of the changes in the profile of newly synthesized proteins detected in cells deprived of P1 and P2 proteins might be due to an effect on the efficiency of cap-independent translation. | Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation.
Martínez-Azorín F, Remacha M, Martínez-Salas E, Ballesta JP. | 01/21/2010 |
| Data indicate that P1/P2 proteins modulate cytoplasmic translation by influencing the interaction between subunits, thereby regulating the rate of cell proliferation. | Functional characterization of ribosomal P1/P2 proteins in human cells.
Martinez-Azorin F, Remacha M, Ballesta JP. | 01/21/2010 |
| Antisense-mediated depletion may disrupt the proteome of cancer cells. | Ribosomal protein P2: a potential molecular target for antisense therapy of human malignancies.
Gardner-Thorpe J, Ito H, Ashley SW, Whang EE. | 01/21/2010 |
| Ribosomal protein P2 has been identified as a novel substrate of GRK2 in HEK-293 cells where P2 phosphorylation is increased following agonist stimulation of the beta 2-adrenergic receptor under conditions of tyrosine kinase PKC and PKA inhibition. | Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.
Freeman JL, Gonzalo P, Pitcher JA, Claing A, Lavergne JP, Reboud JP, Lefkowitz RJ. | 01/21/2010 |
| Distinct roles for CD39 and P2-purinergic signaling in both tissue remodeling and fibrogenesis with respect to human pancreatic diseases. | Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease.
Künzli BM, Berberat PO, Giese T, Csizmadia E, Kaczmarek E, Baker C, Halaceli I, Büchler MW, Friess H, Robson SC. | 01/21/2010 |
| the P1 and P2 proteins are not actively transported into the nucleus compartment, remaining predominantly in the cytoplasm (the perinuclear compartment). | The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins.
Tchórzewski M, Krokowski D, Rzeski W, Issinger OG, Grankowski N. | 01/21/2010 |