| RPS27 selectively regulates the expression and alternative splicing of inflammatory and immune response genes in thyroid cancer cells. | RPS27 selectively regulates the expression and alternative splicing of inflammatory and immune response genes in thyroid cancer cells.
Wan J, Lv J, Wang C, Zhang L. | 09/3/2022 |
| Hsp90 chaperone code and the tumor suppressor VHL cooperatively regulate the mitotic checkpoint. | Hsp90 chaperone code and the tumor suppressor VHL cooperatively regulate the mitotic checkpoint.
Woodford MR, Backe SJ, Wengert LA, Dunn DM, Bourboulia D, Mollapour M., Free PMC Article | 03/5/2022 |
| Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival. | Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival.
Xiong X, Cui D, Bi Y, Sun Y, Zhao Y. | 04/24/2021 |
| Functional analysis of RPS27 mutations and expression in melanoma. | Functional analysis of RPS27 mutations and expression in melanoma.
Floristán A, Morales L, Hanniford D, Martinez C, Castellano-Sanz E, Dolgalev I, Ulloa-Morales A, Vega-Saenz de Miera E, Moran U, Darvishian F, Osman I, Kirchhoff T, Hernando E., Free PMC Article | 02/6/2021 |
| this study indicates that MPS-1 promotes leptin-induced colorectal cancer (CRC) via activating JNK/c-Jun pathway. MPS-1 might represent a potent candidate for the treatment and prognostic prediction of obesity-associated CRC. | Metallopanstimulin-1 (MPS-1) mediates the promotion effect of leptin on colorectal cancer through activation of JNK/c-Jun signaling pathway.
Cao D, Luo Y, Qin S, Yu M, Mu Y, Ye G, Yang N, Cong Z, Chen J, Qin J, Cui R, Jing R, Cao H, Zhong M., Free PMC Article | 08/1/2020 |
| Chloride anion behaves as a signaling effector for CFTR in the modulation of RPS27 expression. | CFTR modulates RPS27 gene expression using chloride anion as signaling effector.
Valdivieso ÁG, Mori C, Clauzure M, Massip-Copiz M, Santa-Coloma TA. | 11/4/2017 |
| reveal how Mps1 dynamically modifies kinetochores to correct improper attachments and ensure faithful chromosome segregation | Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation.
Maciejowski J, Drechsler H, Grundner-Culemann K, Ballister ER, Rodriguez-Rodriguez JA, Rodriguez-Bravo V, Jones MJK, Foley E, Lampson MA, Daub H, McAinsh AD, Jallepalli PV., Free PMC Article | 09/16/2017 |
| MPS1 is a new marker of Purkinje Cells. | A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum.
Fernandez-Pol JA. | 12/31/2016 |
| Loss of function mutations in RPL27 and RPS27 lead to Diamond-Blackfan anaemia. | Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.
Wang R, Yoshida K, Toki T, Sawada T, Uechi T, Okuno Y, Sato-Otsubo A, Kudo K, Kamimaki I, Kanezaki R, Shiraishi Y, Chiba K, Tanaka H, Terui K, Sato T, Iribe Y, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Hara J, Goi K, Matsubara K, Koike K, Ishiguro A, Okamoto Y, Watanabe K, Kanno H, Kojima S, Miyano S, Kenmochi N, Ogawa S, Ito E. | 05/16/2015 |
| We identified frequent recurrent (i.e. hotspot) mutation in the 5' untranslated region of RPS27 in ~10% of melanoma samples | A highly recurrent RPS27 5'UTR mutation in melanoma.
Dutton-Regester K, Gartner JJ, Emmanuel R, Qutob N, Davies MA, Gershenwald JE, Robinson W, Robinson S, Rosenberg SA, Scolyer RA, Mann GJ, Thompson JF, Hayward NK, Samuels Y., Free PMC Article | 01/24/2015 |
| The data on genome context analysis indicates that the presence of MPS-1 in the blood is an indicator of oncogenesis | Increased serum level of RPMPS-1/S27 protein in patients with various types of cancer is useful for the early detection, prevention and therapy.
Fernandez-Pol JA. | 01/5/2013 |
| a novel pathway, the MPS-1/NF-kappaB/Gadd45beta signal pathway, played an important role in MPS-1 knockdown-induced apoptosis of gastric cancer cells. | Knockdown of metallopanstimulin-1 inhibits NF-κB signaling at different levels: the role of apoptosis induction of gastric cancer cells.
Yang ZY, Qu Y, Zhang Q, Wei M, Liu CX, Chen XH, Yan M, Zhu ZG, Liu BY, Chen GQ, Wu YL, Gu QL. | 06/9/2012 |
| This work is consistent with a critical role of RPMPS-1/S27 in the life cycle of various viruses and shows that disruption of viral ZFPs is potentially important to control and prevent deathly viral diseases | Conservation of multifunctional ribosomal protein metallopanstimulin-1 (RPS27) through complex evolution demonstrates its key role in growth regulation in Archaea, eukaryotic cells, DNA repair, translation and viral replication.
Fernandez-Pol JA. | 07/30/2011 |
| study reveals a multilevel interplay between RPS27L/S27 and p53-MDM2 axis, with RPS27L functioning as a p53 target, a MDM2 substrate and a p53 regulator | Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator.
Xiong X, Zhao Y, He H, Sun Y., Free PMC Article | 06/18/2011 |
| When MPS-1 is overexpressed, it has an extraribosomal function as a strong inhibitor of HNSCC tumor cell growth, which may be exerted by reduced paxillin gene expression. | Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth.
Dai Y, Pierson SE, Dudney WC, Stack BC Jr. | 01/25/2010 |
| MPS-1 was overexpressed in 86% of the gastric cancer tissues and all gastric cancer cells. MPS-1 expression was significantly increased and corresponded with the tumor-node-metastasis clinical stage, and was significantly higher in the late stage. | In vitro and in vivo evidence of metallopanstimulin-1 in gastric cancer progression and tumorigenicity.
Wang YW, Qu Y, Li JF, Chen XH, Liu BY, Gu QL, Zhu ZG. | 01/21/2010 |