| The ancestral type of the R-RAS protein has oncogenic potential. | The ancestral type of the R-RAS protein has oncogenic potential.
Talajić A, Dominko K, Lončarić M, Ambriović-Ristov A, Ćetković H., Free PMC Article | 02/26/2024 |
| METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS. | METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS.
Chen JX, Chen DM, Wang D, Xiao Y, Zhu S, Xu XL., Free PMC Article | 03/27/2023 |
| R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. | R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Weber SM, Brossier NM, Prechtl A, Barnes S, Wilson LS, Brosius SN, Longo JF, Carroll SL., Free PMC Article | 02/26/2022 |
| R-Ras activation is associated melanoma tumorigenesis. | Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.
Sung H, Kanchi KL, Wang X, Hill KS, Messina JL, Lee JH, Kim Y, Dees ND, Ding L, Teer JK, Yang S, Sarnaik AA, Sondak VK, Mulé JJ, Wilson RK, Weber JS, Kim M., Free PMC Article | 02/24/2018 |
| this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer | Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.
Xu L, Gao Y, Chen Y, Xiao Y, He Q, Qiu H, Ge W., Free PMC Article | 01/20/2018 |
| SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. | SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.
Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J., Free PMC Article | 06/24/2017 |
| Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling. | R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.
Sawada J, Li F, Komatsu M., Free PMC Article | 08/20/2016 |
| RRAS is a key regulator of miR-34/449 promotion of actin network formation during multiciliogenesis. | miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways.
Chevalier B, Adamiok A, Mercey O, Revinski DR, Zaragosi LE, Pasini A, Kodjabachian L, Barbry P, Marcet B., Free PMC Article | 05/7/2016 |
| Evidence is provided of a functional link between RRAS and MAPK signalling and reveal an unpredicted role of enhanced RRAS function in human disease. | Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
Flex E, Jaiswal M, Pantaleoni F, Martinelli S, Strullu M, Fansa EK, Caye A, De Luca A, Lepri F, Dvorsky R, Pannone L, Paolacci S, Zhang SC, Fodale V, Bocchinfuso G, Rossi C, Burkitt-Wright EM, Farrotti A, Stellacci E, Cecchetti S, Ferese R, Bottero L, Castro S, Fenneteau O, Brethon B, Sanchez M, Roberts AE, Yntema HG, Van Der Burgt I, Cianci P, Bondeson ML, Cristina Digilio M, Zampino G, Kerr B, Aoki Y, Loh ML, Palleschi A, Di Schiavi E, Carè A, Selicorni A, Dallapiccola B, Cirstea IC, Stella L, Zenker M, Gelb BD, Cavé H, Ahmadian MR, Tartaglia M., Free PMC Article | 03/26/2016 |
| Girdin regulates the trafficking of VE-cadherin in synergy with R-Ras. | Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.
Ichimiya H, Maeda K, Enomoto A, Weng L, Takahashi M, Murohara T. | 08/1/2015 |
| phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. | OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.
Weber-Boyvat M, Kentala H, Lilja J, Vihervaara T, Hanninen R, Zhou Y, Peränen J, Nyman TA, Ivaska J, Olkkonen VM. | 04/25/2015 |
| Contradicting the positive association reported in previous studies, our results indicate that R-Ras activation may negatively regulate the transformation of breast epithelial cells. | Negative association of R-Ras activation and breast cancer development.
Song J, Zheng B, Bu X, Fei Y, Shi S. | 12/20/2014 |
| A polymorphism linked to RRAS, SCAF1, IRF3 and BCL2L12 genes is associated with cirrhosis in hepatitis C virus carriers. | A polymorphism linked to RRAS, SCAF1, IRF3 and BCL2L12 genes is associated with cirrhosis in hepatitis C virus carriers.
Real LM, Caruz A, Rivero-Juarez A, Soriano V, Neukam K, Rivero A, Cifuentes C, Mira JA, Macías J, Pineda JA. | 11/22/2014 |
| Patients with gemistocytic astrocytomas with an RRAS deletion tend to have shorter survival rates than those without deletion. | Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas.
Ohta T, Kim YH, Oh JE, Satomi K, Nonoguchi N, Keyvani K, Pierscianek D, Sure U, Mittelbronn M, Paulus W, Vital A, Yokoo H, McDonald K, Kleihues P, Nazaret N, Barbet F, Lachuer J, Ohgaki H. | 11/22/2014 |
| These data suggest that pharmacological inhibition of RRAS signaling may confer therapeutic benefit in Huntington's disease. | A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE., Free PMC Article | 05/18/2013 |
| These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization. | Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.
Sawada J, Urakami T, Li F, Urakami A, Zhu W, Fukuda M, Li DY, Ruoslahti E, Komatsu M., Free PMC Article | 10/27/2012 |
| Maintaining endothelial barrier function is dependent upon active R-Ras and association between R-Ras and FLNa. | R-Ras interacts with filamin a to maintain endothelial barrier function.
Griffiths GS, Grundl M, Allen JS 3rd, Matter ML., Free PMC Article | 08/20/2011 |
| Data suggest that the RRAS gene is an important regulatory module in the pathogenesis of biliary atresia (BA), which may serve as a novel prognostic marker for BA. | RRAS: A key regulator and an important prognostic biomarker in biliary atresia.
Zhao R, Li H, Shen C, Zheng S., Free PMC Article | 07/23/2011 |
| data support a model in which R-Ras functionally associates with FLNa and thereby regulates integrin-dependent migration | R-Ras regulates migration through an interaction with filamin A in melanoma cells.
Gawecka JE, Griffiths GS, Ek-Rylander B, Ramos JW, Matter ML., Free PMC Article | 01/15/2011 |
| Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. | Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.
Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS., Free PMC Article | 06/28/2010 |
| the monomeric intracellular plexin-B1 binds R-Ras but not H-Ras. These findings suggest that the monomeric form of the intracellular region is primed for GAP activity and extend a model for plexin activation. | Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
Tong Y, Hota PK, Penachioni JY, Hamaneh MB, Kim S, Alviani RS, Shen L, He H, Tempel W, Tamagnone L, Park HW, Buck M., Free PMC Article | 01/21/2010 |
| results map the functional elements in the R-ras promoter sequence and suggest that the GABP may be critical for transcription of R-ras and for maintenance of normal blood vessel functions through the regulation of this gene | Promoter cloning and characterization of the anti-vascular proliferation gene, R-ras: role of Ets- and Sp-binding motifs.
Xu L, Komatsu M. | 01/21/2010 |
| TCF8 activates R-Ras, another class of angiogenic regulator, to suppress angiogenesis by a mechanism other than a transcriptional attenuator. | Transcription factor 8 activates R-Ras to regulate angiogenesis.
Inuzuka T, Tsuda M, Kawaguchi H, Ohba Y. | 01/21/2010 |
| Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway. | Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.
Hodkinson PS, Elliott PA, Lad Y, McHugh BJ, MacKinnon AC, Haslett C, Sethi T. | 01/21/2010 |
| activation of R-Ras promotes the formation of focal adhesions and a spread cell shape | The C-terminal end of R-Ras contains a focal adhesion targeting signal.
Furuhjelm J, Peränen J. | 01/21/2010 |