| Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. | Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
Yi J, Bertels Z, Del Rosario JS, Widman AJ, Slivicki RA, Payne M, Susser HM, Copits BA, Gereau RW 4th., Free PMC Article | 12/22/2023 |
| Function and structure of bradykinin receptor 2 for drug discovery. | Function and structure of bradykinin receptor 2 for drug discovery.
Shen JK, Zhang HT., Free PMC Article | 03/2/2023 |
| The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency. | The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
Dyga W, Obtulowicz A, Mikolajczyk T, Bogdali A, Dubiela P, Obtulowicz K., Free PMC Article | 10/8/2022 |
| Cryo-EM structures of human bradykinin receptor-Gq proteins complexes. | Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes.
Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H., Free PMC Article | 03/5/2022 |
| ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors. | ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.
Portales AE, Mustafá ER, McCarthy CI, Cornejo MP, Couto PM, Gironacci MM, Caramelo JJ, Perelló M, Raingo J., Free PMC Article | 02/26/2022 |
| Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children. | Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.
Souza LV, de Almeida SS, De Meneck F, Thomazini F, Araujo RC, Franco do MC. | 01/1/2022 |
| Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors. | Association of Variants Near the Bradykinin Receptor B(2) Gene With Angioedema in Patients Taking ACE Inhibitors.
Ghouse J, Ahlberg G, Andreasen L, Banasik K, Brunak S, Schwinn M, Larsen IH, Petersen O, Sørensen E, Ullum H, Rasmussen ER, Eriksson N, Hallberg P, Wadelius M, Bundgaard H, Olesen MS. | 12/18/2021 |
| Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene. | Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
Gagnon M, Savard M, Jacques JF, Bkaily G, Geha S, Roucou X, Gobeil F., Free PMC Article | 08/28/2021 |
| BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma. | BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.
Yang Y, Wang J, Shi F, Shan A, Xu S, Lv W., Free PMC Article | 07/24/2021 |
| Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis. | Down-regulation of B2R contributes to preeclampsia by inhibiting human trophoblast cell invasion and angiogenesis.
Peng Y, Liu D, Diao Z, Wang Z, Ding H, Cai B, Hu Y, Zhao G, Zheng M. | 05/29/2021 |
| Bradykinin stimulates prostaglandin E2 release in human skeletal muscular fibroblasts. | Bradykinin stimulates prostaglandin E(2) release in human skeletal muscular fibroblasts.
Muscella A, Cossa LG, Vetrugno C, Marsigliante S. | 05/1/2021 |
| These results highlight a novel and specific approach to target PKK for the treatment of hereditary angioedema (HAE) and other diseases involving contact system activation and overproduction of bradykinin. | IONIS-PKK(Rx) a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production.
Ferrone JD, Bhattacharjee G, Revenko AS, Zanardi TA, Warren MS, Derosier FJ, Viney NJ, Pham NC, Kaeser GE, Baker BF, Schneider E, Hughes SG, Monia BP, MacLeod AR., Free PMC Article | 07/25/2020 |
| The decreased expression of b2r in chronic plaque lesions of psoriasis vulgaris indicates a protective role of b2r. Moreover, the intensity of b2r expression was dependent on the epidermal thickness, suggesting the implication of b2r in the pathogenesis of psoriasis. | Aberrant expression of bradykinin b2 receptor in the epidermis of patients with psoriasis vulgaris.
Liu H, Zhang M, Dong X, Liu F, Sang H. | 03/28/2020 |
| Low expression of B2R on circulating progenitor cells is associated with heart failure. | Expression of B2 Receptor on Circulating CD34-Positive Cells and Outcomes of Myocardial Infarction.
Fu C, Cao Y, Yao Y, Tang S, Fan Q, Ling Y., Free PMC Article | 01/11/2020 |
| Data found that the serum BK levels and the levels of its receptor, B2R, were overexpressed in patients with cervical cancer (CC). B2R exhibited a high expression even in cervical intraepithelial neoplasia (CIN) tissues. | Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2.
Zhou Y, Wang W, Wei R, Jiang G, Li F, Chen X, Wang X, Long S, Ma D, Xi L., Free PMC Article | 12/21/2019 |
| BDKRB2 role in the genetic predisposition to the deep venous thrombosis after orthopedic surgery in the Han Chinese population . | Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator.
Wang Q, Cheng G, Wang X, Wang D, Yang Y, Chen K, Ye J, Qing Z., Free PMC Article | 12/14/2019 |
| BDKRB2 rs1799722 was associated with differences blood pressure response to static handgrip exercise but not mental stress. | TRPV1 and BDKRB2 receptor polymorphisms can influence the exercise pressor reflex.
Notay K, Klingel SL, Lee JB, Doherty CJ, Seed JD, Swiatczak M, Mutch DM, Millar PJ., Free PMC Article | 11/9/2019 |
| BKR2 expression levels in subcutaneous white adipose tissue did not differ significantly between patients with and without coronary artery disease. | Bradykinin receptors gene expression in white adipose tissue in nondiabetic patients with coronary artery disease.
Marketou ME, Kochiadakis G, Kontaraki J, Zacharis E, Kanoupakis E, Kallergis E, Mavrakis H, Tsiverdis P, Lempidakis D, Konstantinou J, Fragkiadakis K, Chlouverakis G, Vardas P, Parthenakis F. | 06/22/2019 |
| Signal crosstalk between purinergic receptor P2Y2 (P2Y2R) and bradykinin B2 receptor (B2R) occurs in lipid rafts. | Regulation of membrane raft recruitment of the bradykinin B2 receptor by close association with the ATP/UTP receptor P2Y(2).
Nakagawa T, Takahashi C, Matsuzaki H, Kuroda Y, Higashi H. | 06/1/2019 |
| BK receptors, B1 and B2 (BKR-B1 and B2), were also detected in both epithelial and stromal cells of endometriotic lesions. The localization of BKR-B1 was nucleus mainly, whereas BKR-B2 was detected at cytoplasm. | Bradykinin system is involved in endometriosis-related pain through endothelin-1 production.
Yoshino O, Yamada-Nomoto K, Kobayashi M, Andoh T, Hongo M, Ono Y, Hasegawa-Idemitsu A, Sakai A, Osuga Y, Saito S. | 01/12/2019 |
| Study results indicated that the bradykinin B2 receptor-mediated pathway is involved in the cPLA2-related inflammatory response from the PKC pathway in traumatic brain injury. | Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A(2) after the early traumatic brain injury.
Chao H, Liu Y, Lin C, Xu X, Li Z, Bao Z, Fan L, Tao C, Zhao L, Liu Y, Wang X, You Y, Liu N, Ji J. | 12/22/2018 |
| The most characteristic signaling pathways for B2R and D2R, dependent on intracellular Ca(2+) and cAMP concentration, respectively, were analyzed in cells presenting similar endogenous expression of B2R and D2R.The evidence of B2R-D2R dimerization may open new perspectives in the modulation of diverse cellular functions which depend on their activation. | Bradykinin B2 and dopamine D2 receptors form a functional dimer.
Niewiarowska-Sendo A, Polit A, Piwowar M, Tworzydło M, Kozik A, Guevara-Lora I. | 12/9/2017 |
| These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation. | Novel signaling of dynorphin at κ-opioid receptor/bradykinin B2 receptor heterodimers.
Ji B, Liu H, Zhang R, Jiang Y, Wang C, Li S, Chen J, Bai B. | 12/2/2017 |
| Study demonstrated the ability of long-chain polyunsaturated fatty acids to act as agonist to the B2R at nanomolar concentrations and to induce receptor conformational changes. | Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids.
Candelario J, Chachisvilis M., Free PMC Article | 10/14/2017 |
| Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC). | NMI promotes hepatocellular carcinoma progression via BDKRB2 and MAPK/ERK pathway.
Zhao J, Dong QZ, Zhong F, Cai LL, Qin ZY, Liu Y, Lin CZ, Qin LX, He FC., Free PMC Article | 08/12/2017 |